Download or read book Monoclonal Antibodies written by Maher Albitar and published by Springer Science & Business Media. This book was released on 2007-06-25 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.

Download or read book Monoclonal Antibodies written by Heddy Zola and published by CRC Press. This book was released on 1987-07-31 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and the choices between methods. It also provides a rational basis where several alternative methods are available.

Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by Suresh C. Srivastava and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

Download or read book The Pharmacology of Monoclonal Antibodies written by Martin Rosenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

Download or read book Monoclonal Antibodies written by Christian Klein and published by MDPI. This book was released on 2018-04-27 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies

Download or read book Monoclonal Antibodies written by Barton Haynes and published by Elsevier. This book was released on 2012-12-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity. The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology. Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material.

Download or read book A Practical Guide to Monoclonal Antibodies written by J. Eryl Liddell and published by John Wiley & Sons. This book was released on 1991-08-26 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes all of the information required to produce monoclonal antibodies in the laboratory and to prepare them for use in a multitude of given applications. Production procedures are treated in chronological order, beginning with basic tissue culture techniques, immunization strategies and screening test design, followed by production of hybridoma cell lines and basic antibody characterization, purification and labeling. Each chapter contains explanatory text on each step with comparative analysis of methods where appropriate. All necessary experimental protocols are presented in a self-contained format that is easy to follow in the laboratory. Alternative protocols are provided where relevant; for others not included in full, source references are presented. Surveys the current status of human hybridoma production and antibody engineering using molecular biology techniques.

Download or read book Monoclonal Antibodies written by Harleen Kaur and published by Elsevier. This book was released on 2021-08-03 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization. Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimilars and new antibody formats

Download or read book Monoclonal Antibodies in Diagnostic Immunohistochemistry written by Mark Wick and published by CRC Press. This book was released on 1988-03-30 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methodology of monoclonal antibody-mediated immunohistochemistry, as applied to practical tissue diagnosis. It focuses on human disease and discusses the spectrum of monoclonal antibodies in relation to its utility in solving differential diagnostic problems.

Download or read book Monoclonal Antibodies in Biotechnology written by Kenneth C. McCullough and published by Cambridge University Press. This book was released on 1990-04-19 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal antibodies are one of the most exciting developments in biotechnology in recent years; this book provides a comprehensive description of principles, methodologies and applications of this powerful technology to modern science and industry.

Download or read book Monoclonal Antibodies written by Phil S. Shepherd and published by OUP Oxford. This book was released on 2000-05-04 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Download or read book Clinical Applications of Monoclonal Antibodies written by Ron Hubbard and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology has come a long way in the hundred or so years since the general concepts were first enuciated by Metchnikoff, Ehrlich, Von Bebring and others, One of the landmarks in this progress was the invention and development of monoclonal antibody secreting hybridomas by Milstein and bis co-workers in Cambridge. Unlike most modern inventions of this importance that of monoclonal antibody production was made available to the scientific community tbroughout the world unimpeded by patent protection. This may explain tbe unusual rapidity witb which it has been applied to the benefit of mankind in general. This book, representing as it does the proceedings of tbe first International Symposium to be held on the clinical appli cations of monoclonal antibodies, shows just how much bas been achieved within the space of little more than a decade. The enormaus promise of monoclonal antibody technology, which became apparent soon after its discovery, has already progressed a long way towards fulfillment. The contributors to tbis volume, all of whom are actively engaged in monoclonal antibody development and application, represent the state of the art. Professor Vincent Marks V INTRODUCTION It has been some twelve years since the pioneering experiments of Köhler and Milstein led to the discovery of monoclonal antibodies. Single molecular species antiborlies with desired specificities could be produced by the fusion of antibody - producing cells with neoplastic cells.

Download or read book Monoclonal Antibodies written by Mary A. Ritter and published by Cambridge University Press. This book was released on 1995-01-26 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications.

Download or read book Monoclonal Antibodies Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal Antibodies: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Monoclonal Antibodies. The editors have built Monoclonal Antibodies: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monoclonal Antibodies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Monoclonal Antibodies: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book The Lock and Key of Medicine written by Lara Marks and published by Yale University Press. This book was released on 2015-01-01 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies, or Mabs. Though unfamiliar to most nonscientists, these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. They have radically changed understandings of the pathways of disease, enabling faster, cheaper, and more accurate clinical diagnostic testing. And they lie at the heart of the development of genetically engineered drugs such as interferon and blockbuster personalized therapies such as Herceptin. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs who ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, controversies over Mabs remain, which the author explores through the current debates on their cost-effectiveness.

Download or read book Monoclonal Antibodies to Receptors written by M.F. Greaves and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Monoclonal Antibodies against Bacteria written by Alberto Macario and published by Elsevier. This book was released on 2012-12-02 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal Antibodies against Bacteria, Volume I explores the generation, characterization, and utilization of monoclonal antibodies against bacteria and on other monoclonal products relevant to antibacterial immune responses. Organized into 12 chapters, this book begins with a discussion on monoclonal antibodies against bacteria, encompassing its scope, research, and directions. It shows that the coordinated use of antisera and panels of monoclonal antibodies is proving useful for classification as a diagnostic tool with prognostic implications in the case of pathogens, or as a preliminary step in taxonomy. Also, monoclonal antibodies hold great potential as instruments in working with bacteria for industrial or biotechnological purposes, including genetic engineering. This book also elucidates the use of monoclonal antibodies of predefined molecular specificity for tracing molecular ""signatures"" left by a given strain in other microorganisms, subcellular structures, and materials from ecologic niches. The possibility of antibacterial and antitoxin therapies with monoclonal antibodies is also addressed. This treatise will be a valuable reference work to anyone working with monoclonal antibodies or getting ready to prepare them against the strain(s) (or bacterial structures) of his/her interest.