Download or read book Antibody Mediated Drug Delivery Systems written by Yashwant V. Pathak and published by John Wiley & Sons. This book was released on 2012-05-15 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.
Download or read book Antibody mediated Delivery Systems written by John D. Rodwell and published by Marcel Dekker. This book was released on 1988 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Drug Delivery Systems 6 written by James M. Anderson and published by Elsevier. This book was released on 2013-10-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.
Download or read book Drug Delivery Systems written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.
Download or read book Silk based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Download or read book Liposome Based Drug Delivery Systems written by Wan-Liang Lu and published by Springer. This book was released on 2021-07-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investigators, laying the groundwork is the first step. This part focuses on the fabrication details in liposomes formulations, which are the so-called small tricks while usually not disclosed in mostly published research articles. However, these processing details are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiological environment, as well as their application in treating diseases. As new analytical and synthetic technologies become available, and improved understanding of pathophysiology, various functionalized drug liposomes are developing to fit the requirements of different therapeutic purposes, exhibiting a broad range of applications. Accordingly, the objectives of this part are aimed at deeply unearthing the formulation of drug-loaded liposomes, describing the detailed operation of liposomal formulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises.
Download or read book Drug Targeting and Stimuli Sensitive Drug Delivery Systems written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2018-05-21 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy
Download or read book Design of Controlled Release Drug Delivery Systems written by Xiaoling Li and published by McGraw Hill Professional. This book was released on 2005-11-24 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.
Download or read book Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis written by Padma V. Devarajan and published by Springer Nature. This book was released on 2019-11-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents written by Manju Rawat Singh and published by Academic Press. This book was released on 2020-04-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives
Download or read book Nanoparticulate Drug Delivery Systems for Cancer Therapy written by NaikSachin S and published by Independent Author. This book was released on 2023-03-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular medicine has discovered many new therapeutic modalities by using state-of- the-art techniques in molecular biology. High through-put, in-vitro assays that screen for pharmacological actions on the desired cell type are frequently used to design new drugs. Although such agents are certainly justified by their, success in-vitro, they frequently perform much less effectively in-vivo where the agent must reach its target cells in a tissue in sufficient quantities to be potent while sparing bystander organs. Depending on the route of administration, the endothelium and/or epithelium form significant barriers that greatly limit the in-vivo accessibility of many drugs, antibodies, and gene vectors to their intended target sites of pharmacological action, namely, the cells inside the tissue (Jain, R. K. et al., 1998). Hence, the major challenge for formulation development scientist is to design drug delivery strategies that deliver the therapeutic agents to the desired intracellular targets based on ability to understand, utilize, modify and exploit membrane trafficking pathways (Miller, N. et al., 1995). Intracellular drug delivery refers to the delivery of therapeutic agents to specific compartments or organelles within the cell. The therapeutic agent could be a low molecular weight drug or a macromolecule like protein or DNA. Thus targeted intracellular drug delivery results in higher bioavailability of a therapeutic agent at its site of action (i.e. distinct intracellular compartments or microenvironments), potentiates the pharmacologic effect of the drug, and at the same time, reduces the side effects. (Jayanth Panyam et al, 2004). There are a number of pathways through which a therapeutic agent or a carrier can enter a cell. Such as Endocytosis, Caveolar endocytosis, Pinocytosis, Phagocytosis, In receptor-mediated endocytosis, Folate Receptor-Mediated Endocytosis, Transferrin Receptor-Mediated Endocytosis, Biotin Receptor-Mediated Endocytosis, Wheat Germ Agglutinin-Mediated Endocytosis, ICAM-1-Mediated Endocytosis, Antibody-Mediated Endocytosis, Physical or mechanical methods use force to traverse the cell membrane, e.g. Particle bombardment accelerates, Microinjection and Electroporation. The various Intracellular Targets are Endo-Lysosomal Targeting, Cytoplasmic Delivery, Nuclear Targeting, and Mitochondrial Targeting.
Download or read book Cellular Drug Delivery written by D. Robert Lu and published by Humana Press. This book was released on 2010-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.
Download or read book Microneedle mediated Transdermal and Intradermal Drug Delivery written by Ryan F. Donnelly and published by John Wiley & Sons. This book was released on 2012-01-17 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.
Download or read book Cellular Drug Delivery written by D. Robert Lu and published by Springer Science & Business Media. This book was released on 2004-02-25 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
Download or read book Drug Delivery Systems Advanced Technologies Potentially Applicable in Personalised Treatment written by Jorge Coelho and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
