Download or read book Antibiotic Resistance Challenges and Opportunities an Issue of Infectious Disease Clinics of North America written by Robert A. Bonomo and published by Elsevier. This book was released on 2016-06-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, physicians and the public assumed that the discovery of new antimicrobial agents would outpace the ability of bacteria to mutate and develop drug resistance. Yet the development of new antibiotics has not kept up with bacterial evolution, especially since the late 1990's. At that time a multitude of pharmaceutical companies abandoned antibiotic research because of strong economic disincentives. For example, it is challenging for these companies to recuperate the investment (typically in the hundreds of millions of dollars) made in developing a new antibiotic, which is typically prescribed for a few days, compared to drugs that treat chronic conditions like heart disease or mental illness. This situation has led the U.S. federal government to take a more active lead in addressing antibiotic resistance. Recently, the White House announced an action plan that includes improving surveillance, developing better diagnostic tools, accelerating drug development, and improving global coordination of antibiotic resistance issues. Equally important is the $1.2 billion dollars that has been pledged to fund these efforts. While we await the implementation of new policies, this issue of Infectious Disease Clinics of North America brings together leading authorities in the field of antibiotic resistance who discuss current issues including antibiotic stewardship, the changing role of the microbiology laboratory in determining antibiotic resistance in gram-negative pathogens, the continuing spread of metallo-ß-lactamases, ESBLs and KPCs, antibiotic options for treating resistant gram-negative infections such as colistin and tigecycline, resistance mechanisms and new treatment options for Mycobacterium tuberculosis, emerging resistance mechanisms in aminoglycosides, issues with antibiotic resistance in immunocompromised patients, new ß-lactamase inhibitors in the clinic, and resistance in VRE and Staphylococcus aureus. Additionally, combination therapy for resistant gram-negative infections has been advocated by some authorities and the advantages and disadvantages of this strategy will be reviewed.
Download or read book The Ongoing Challenge of Antimicrobial Resistance An Issue of Infectious Disease Clinics of North America EBook written by Richard R. Watkins and published by Elsevier Health Sciences. This book was released on 2020-11-11 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with Consulting Editor Dr. Helen Boucher, Drs. Watkins and Bonomo have put together an issue of Infectious Disease Clinics of North America that provides the most current information on antibiotic resistance. Top experts have contributed clinical review articles that address the types of resistance based on drug class as well as emerging therapies and the future of telemedicine in the management of infections. The following topics are covered in this issue: The changing role of the clinical microbiology laboratory in defining resistance in gram-negatives; Extended-spectrum ß-lactamase-producing Enterobacteriaceae infections; Multidrug-resistant bacteria in the community; Resistance to polymyxins; Resistance in Vancomycin-resistant enterococci; Resistance to newer ß-lactamase inhibitors; Antibiotic-resistant infections in the immunocompromised host; Emerging therapies for MRSA infections; Drug-resistant tuberculosis; Aminoglycoside resistance; The role of antibiotic stewardship and telemedicine in the management of MDR infections; and Emerging issues in antifungal resistance. Readers will have the current information they need to better manage antibiotic-resistant infections in patients.
Download or read book The Ongoing Challenge of Antimicrobial Resistance an Issue of Infectious Disease Clinics of North America written by Richard R. Watkins and published by Elsevier. This book was released on 2020-09-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with Consulting Editor Dr. Helen Boucher, Drs. Watkins and Bonomo have put together an issue of Infectious Disease Clinics of North America that provides the most current information on antibiotic resistance. Top experts have contributed clinical review articles that address the types of resistance based on drug class as well as emerging therapies and the future of telemedicine in the management of infections. The following topics are covered in this issue: The changing role of the clinical microbiology laboratory in defining resistance in gram-negatives; Extended-spectrum ?-lactamase-producing Enterobacteriaceae infections; Multidrug-resistant bacteria in the community; Resistance to polymyxins; Resistance in Vancomycin-resistant enterococci; Resistance to newer ?-lactamase inhibitors; Antibiotic-resistant infections in the immunocompromised host; Emerging therapies for MRSA infections; Drug-resistant tuberculosis; Aminoglycoside resistance; The role of antibiotic stewardship and telemedicine in the management of MDR infections; and Emerging issues in antifungal resistance. Readers will have the current information they need to better manage antibiotic-resistant infections in patients.
Download or read book Urinary Tract Infection Challenges Beyond the Basics An Issue of Infectious Disease Clinics of North America E Book written by Kalpana Gupta and published by Elsevier Health Sciences. This book was released on 2024-05-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Infectious Disease Clinics, guest editor Kalpana Gupta brings her considerable expertise to the topic of Urinary Tract Infection Challenges. This issue aims to serve clinicians and scholars well over the next decade, with the goal of helping the principles that are currently "beyond the basics" become part of everyday armamentarium. Contains 11 relevant, practice-oriented topics including Reducing Treatment of Asymptomatic Bacteriuria; Diagnostic Stewardship for Urine Cultures; Urinary Tract Infection in Male Patients; Urinary Tract Infection Diagnostic and Management Considerations in People with Spinal Cord Injury and Neurogenic Bladder; and more. Provides in-depth clinical reviews on UTI Challenges, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Infection Prevention and Control in Healthcare Part II Epidemiology and Prevention of Infections An Issue of Infectious Disease Clinics of North America E Book written by Keith S. Kaye and published by Elsevier Health Sciences. This book was released on 2016-11-07 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Kaye and Dr. Dhor have assembled top experts to write about clinical management of infections in Part II of their two issues devoted to Infection Prevention and Control in Healthcare. Articles in this issue are devoted to: CLABSI; UTI; Tuberculosis; Ventilator-Assisted Pneumonia; Surgical Site Infection; MRSA; VRE; Gram-Negative Bacilli; Fungal Infections; C. Difficile, and Emerging Infections including Ebola. Infectious Disease physicians and anyone in the hospital setting will find this issue very useful, as state-of-the-art clinical reviews provide clinical management on these common and emerging infections.
Download or read book Antimicrobial Resistance written by Institute of Medicine and published by National Academies Press. This book was released on 1998-05-13 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic resistance is neither a surprising nor a new phenomenon. It is an increasingly worrisome situation, however, because resistance is growing and accelerating while the world's tools for combating it decrease in power and number. In addition, the cost of the problemâ€"especially of multidrug resistanceâ€"in terms of money, mortality, and disability are also rising. This book summarizes a workshop on antimicrobial resistance held by the Forum on Emerging Infections. The goal of the Forum on Emerging Infections is to provide an opportunity for representatives of academia, industry, government, and professional and interest groups to examine and discuss scientific and policy dilemmas of common interest that are specifically related to research on and the prevention, detection, and management of emerging infections. Organized as a topic-by-topic synthesis of presentations and exchanges during the workshop, the book highlights lessons learned, delineates a range of pivotal issues and the problems they raise, and proposes some simplified ideas about possible responses.
Download or read book Antimicrobial Stewardship Where We ve Come and Where We re Going An Issue of Infectious Disease Clinics of North America E Book written by Emily Sydnor Spivak and published by Elsevier Health Sciences. This book was released on 2023-10-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Infectious Disease Clinics of North America, guest editors Drs. Emily Sydnor Spivak and Sage Greenlee bring their considerable expertise to the topic of Antimicrobial Stewardship: Where We Have Come and Where We Are Going. Throughout the last decade, the field of antimicrobial stewardship has undergone exponential growth due to heightened awareness of antimicrobial use and emerging multidrug-resistant organisms. Additionally, the COVID-19 pandemic highlighted systemic and persistent health disparities in the United States. In this issue, top experts provide a recap of the progress made over the last decade in antimicrobial stewardship and provide direction for next steps in this ever-growing field. Contains 12 practice-oriented topics including antimicrobial stewardship and pandemic preparedness: lessons learned from COVID-19; health equity considerations; antimicrobial stewardship at transitions of care; antimicrobial stewardship in immunocompromised populations; health system and tele-antimicrobial stewardship: the role of building networks; and more. Provides in-depth clinical reviews on antimicrobial stewardship, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book After the COVID 19 Crisis Update on Complex Infectious Disease Issues in the Intensive Care Unit An Issue of Infectious Disease Clinics of North America E Book written by Naomi P. O'Grady and published by Elsevier Health Sciences. This book was released on 2022-11-03 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians. Contains 13 practice-oriented topics including timing and spectrum of antibiotic treatment for suspected sepsis and septic shock; preparing an ICU for a lethal viral respiratory pandemic; rapid implementation of a system-level ICU pandemic surge staffing amidst quarantined staff and infection control barriers; management of serious SARS-CoV-2 infection with immunotherapies; supportive care in patients with critical COVID-19; and more. Provides in-depth clinical reviews on complex infectious diseases issues in the ICU, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Pediatric Infections An Issue of Infectious Disease Clinics of North America E Book written by Jason G. Newland and published by Elsevier Health Sciences. This book was released on 2022-02-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Infections, An Issue of Infectious Disease Clinics of North America, E-Book
Download or read book Infection Prevention and Control in Healthcare Part I Facility Planning and Management An Issue of Infectious Disease Clinics of North America E Book written by Keith S. Kaye and published by Elsevier Health Sciences. This book was released on 2016-08-16 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Kaye and Dr. Dhor have assembled top experts to write about facility planning and management in Part I of their two issues devoted to Infection Prevention and Control in Healthcare. Articles in this issue are devoted to: Building a Successful Infection Control Program: Key Components, Processes and Economics; Hand Hygiene Sterilization; High Level Disinfection and Environmental Cleaning; Environement of Care; Infection Control in Alternative Healthcare Settings (Long Term Care and Ambulatory); Antibiotic Stewardship; Outbreak Investigations Water Safety in Healthcare/Legionella in the Healthcare Setting; Construction and Renovation; Bloodborne and Body Fluid Exposures - prevention and management of Occupational Health Issues; and Informatics and Statistics in Infection Control. Part II is devoted to clinical management of infections.
Download or read book Combating Antimicrobial Resistance written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: As of 2017, the emergence and spread of antimicrobial resistance continues unabated around the world, leaving devastating health and economic outcomes in its wake. Those consequences will multiply if collaborative global action is not taken to address the spread of resistance. Major drivers of antimicrobial resistance in humans have been accelerated by inappropriate antimicrobial prescribing in health care practices; the inappropriate use of antimicrobials in livestock; and the promulgation of antibiotic resistance genes in the environment. To explore the issue of antimicrobial resistance, the Forum of Microbial Threats planned a public workshop. Participants explored issues of antimicrobial resistance through the lens of One Health, which is a collaborative approach of multiple disciplines - working locally, nationally, and globally - for strengthening systems to counter infectious diseases and related issues that threaten human, animal, and environmental health, with an end point of improving global health and achieving gains in development. They also discussed immediate and short-term actions and research needs that will have the greatest effect on reducing antimicrobial resistance, while taking into account the complexities of bridging different sectors and disciplines to address this global threat. This publication summarizes the presentations and discussions from the workshop.
Download or read book Antibiotic Policies Fighting Resistance written by Ian M. Gould and published by Springer Science & Business Media. This book was released on 2007-08-19 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines many of the crucial issues of resistance in a clinical context, with an emphasis on MRSA; surely the greatest challenge to our antibiotic and infection control policies that modern health care systems have ever seen. Other chapters explore the psychology of prescribing, modern management techniques as an adjunct to antibiotic policies, and the less obvious downsides of antibiotic use.
Download or read book Antimicrobial Resistance written by J. Todd Weber and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preventing, controlling and treating drug-resistant infections is one of the major challenges in modern medicine. Antimicrobial Resistance goes beyond simple definitions and microbiological data to fully explore this rapidly changing area, describing evidence for effective interventions, costs, treatment strategies and directions for future research. Each chapter provides essential background and examines the evidence for an important aspect of prevention and control, treatment strategy or policy decision. Prevention and control strategies are analyzed for inappropriate antimicrobial use, fluoroquinolone-resistant organisms, health-care associated infections and parasitic diseases. Furthermore, treatment strategies for changing resistance patterns are explored for community-acquired pneumonia during an influenza pandemic and infections with community-associated MRSA, extended-spectrum beta-lactamase producing organisms and fungi. Data for policy making are presented in articles that detail the costs of antimicrobial-resistant infections in healthcare settings and the threat of resistance with the introduction of antiretroviral therapy for large populations in the developing world. These reviews show where interventions, surveillance and research will be most useful in the future. Antimicrobial Resistance is an invaluable contribution for infectious disease physicians and public health officials who are interested in the prevention of antimicrobial-resistant infections.
Download or read book HIV An Issue of Infectious Disease Clinics of North America written by Paul Edward Sax and published by Elsevier Health Sciences. This book was released on 2019-08-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Paul Edward Sax has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to HIV. Clinical review articles from expert authors are specifically devoted to the following topics: HIV Diagnostics -- Current Recommendations and Opportunities for Improvement; Update on HIV Prevention -- PreP, PEP, and Other Strategies; Initial Assessment -- What Tests to Order and Why; Why Everyone (Almost) with HIV Needs to be on Treatment -- A Review of the Critical Data; Initial Therapy in the Integrase Inhibitor Era -- Can We Do Better than Two NRTIs plus an INSTI?; Switching Therapy in Patients with Virologic Suppression -- A Why and a How-To Guide; Management of Treatment Failure, With and Without Resistance; Reproduction Options for People with HIV, and Management of Pregnancy; HIV and Addiction – the Role of the ID Clinician; Management of Patients with Advanced HIV Disease – Challenges and Opportunities; HIV and Aging – Focus on Cardiovascular Risk and Metabolic Abnormalities; Key Principles in HIV Pharmacology; One Patient Has Been Cured of HIV – Will There Ever Be More?; and Linkage and Retention in Care – The Keys to Treatment Success. Readers will come away with the latest information they need to manage diagnosis, treatment and outcomes of HIV patients.
Download or read book Antimicrobial Resistance written by Maria Cristina Ossiprandi and published by BoD – Books on Demand. This book was released on 2015-11-26 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic resistance has become a worldwide health issue, globally recognized as the first priority by WHO. Many forms of resistance can spread with remarkable speed and cross international boundaries. World health leaders are devoting efforts to the problem by planning strategies for monitoring the effectiveness of public health interventions and detecting new trends and threats. This volume focuses on the problem from different perspectives, taking into consideration geographical dissemination (soil and water), human medicine (methicillin-resistant Staphylococcus aureus and Klebsiella pneumoniae) and veterinary (Enterococcus spp.) impact and molecular analysis. The purpose of this volume is to provide a useful tool for control and prevention and to discuss useful epidemiological data concerning ways of obtaining an accurate picture of resistance in different communities.
Download or read book Antibiotic Resistance written by Institute of Medicine and published by National Academies Press. This book was released on 2011-01-10 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.
Download or read book Extending the Cure written by Ramanan Professor Laxminarayan and published by Routledge. This book was released on 2010-09-30 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our ability to treat common bacterial infections with antibiotics goes back only 65 years. However, the authors of this report make it clear that sustaining a supply of effective and affordable antibiotics cannot be without changes to the incentives facing patients, physicians, hospitals, insurers, and pharmaceutical manufacturers. In fact, increasing resistance to these drugs is already exacting a terrible price. Every day in the United States, approximately 172 men, women, and children die from infections caused by antibiotic-resistant bacteria in hospitals alone. Beyond those deaths, antibiotic resistance is costing billions of dollars through prolonged hospital stays and the need for doctors to resort to ever more costly drugs to use as substitute treatments. Extending the Cure presents the problem of antibiotic resistance as a conflict between individual decision makers and their short-term interest and the interest of society as a whole, in both present and future: The effort that doctors make to please each patient by prescribing a drug when it might not be properly indicated, poor monitoring of discharged patients to ensure that they do not transmit drug-resistant pathogens to other persons, excesses in the marketing of new antibiotics, and the broad overuse of antibiotics all contribute to the development and spread of antibiotic-resistant bacteria. The book explores a range of policy options that would encourage patients, health care providers, and managed care organizations to serve as more responsible stewards of existing antibiotics as well as proposals that would give pharmaceutical firms greater incentives to develop new antibiotics and avoid overselling. If the problem continues unaddressed, antibiotic resistance has the potential to derail the health care system and return us to a world where people of all ages routinely die from simple infections. As a basis for future research and a spur to a critically important dialogue, Extending the Cure is a fundamental first step in addressing this public health crisis. The Extending the Cure project is funded in part by the Robert Wood Johnson Foundation through its Pioneer Portfolio.