Download or read book Anthracycline and Anthracenedione based Anticancer Agents written by J. William Lown and published by Elsevier Publishing Company. This book was released on 1988 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proceedings of the Workshop on Mitoxantrone Cardiotoxicity and the Workshop on Clinical Evaluation of Anthracycline Cardiotoxicity written by and published by . This book was released on 1984 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anthracycline Chemistry and Biology II written by Karsten Krohn and published by Springer. This book was released on 2009-11-04 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.
Download or read book Approaches to the Synthesis of Xanthone Analogs of the Anthracycline Class of Anticancer Agents written by Michael Mancini and published by . This book was released on 1985 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The compound 4-hydroxy-1- 2- (2-hydroxyethyl)amino ethyl amino xanthone and the 4-methoxy derivative were prepared and found to be inactive in the in vivo P-388 mouse leukemia model system." --
Download or read book Anticancer Agents from Natural Products Second Edition written by Gordon M. Cragg and published by CRC Press. This book was released on 2011-10-10 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Download or read book Anthracycline Chemistry and Biology I written by Karsten Krohn and published by Springer. This book was released on 2009-10-29 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Polysaccharides in Medicinal Applications written by Severian Dumitriu and published by Routledge. This book was released on 2017-10-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates the latest advances in polysaccharide chemistry and structure analysis, with the practical applications of polysaccharides in medicine and pharmacy, highlighting the role of glycoconjugates in basic biological processes and immunology. It also presents recent developments in glycobiology and glycopathology. The work covers bacterial, fungal and cell-wall polysaccharides, microbial and bacterial exopolysaccharides, industrial gums, the biosynthesis of bacterial polysaccharides, and the production of microbial polysaccharides.
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
Download or read book Molecular Aspects of Anticancer Drug DNA Interaction written by Neidle and published by CRC Press. This book was released on 1993-08-16 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Download or read book Cancer Chemotherapy and Biotherapy written by Bruce A. Chabner and published by Lippincott Williams & Wilkins. This book was released on 2011-12-07 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2008-06-04 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention
Download or read book Analogue based Drug Discovery II written by János Fischer and published by John Wiley & Sons. This book was released on 2010-08-24 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.
Download or read book Molecular Basis of Specificity in Nucleic Acid Drug Interactions written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Download or read book Molecular Aspects of Chemotherapy written by David Shugar and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter national Symposium on "Molecular Aspects of Chemotherapy", under the auspices of the International Society of Chemotherapy, and organized by the Committee on Drug Research, Polish Academy of Sciences, and the Department of Biotechnology and Biochemistry, Technical University of Gdansk. This volume includes the texts of the review lectures presented by invited participants on up-to-date achievements, and future perspectives, in molecular mechanisms of inhibition of cellular functions and metabolism, with emphasis on the design and mechanisms of action of chemotherapeutic agents for treatment of bacterial, neoplastic, viral and parasitic diseases. From the Contents, it will be seen that the range of disciplines represented was a broad one, including theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary sessions were supple mented by several poster sessions.
Download or read book DNA targeting Molecules as Therapeutic Agents written by Michael J. Waring and published by Royal Society of Chemistry. This book was released on 2018-03-12 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Download or read book Bioactive Natural Products Part B written by Atta-ur Rahman and published by Elsevier. This book was released on 2000-03-09 with total page 827 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
