Download or read book Smith and Williams Introduction to the Principles of Drug Design and Action Third Edition written by H. John Smith and published by CRC Press. This book was released on 1998-05-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials

Download or read book Cellular Physiology of Nerve and Muscle written by Gary G. Matthews and published by John Wiley & Sons. This book was released on 2013-06-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.

Download or read book Membrane Transport and Renal Physiology written by Harold E. Layton and published by Springer Science & Business Media. This book was released on 2002-08-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume arose out of the workshop Membrane Transport and Renal Physiology, which was conducted as part of the IMA 1998-1999 program year, Mathematics in Biology. The workshop brought together physiologists, biophysicists, and applied mathematicians who share a common interest in solute and water transport in biological systems, especially in the integrated function of the kidney. Solute and water transport through cells involves fluxes across two cell membranes, usually via specialized proteins that are integral membrane components. By means of mathematical representations, transport fluxes can be related to transmembrane solute concentrations and electrochemical driving forces. At the next level of functional integration, these representations can serve as key components for models of renal transcellular transport. Ultimately, simulations can be developed for transport-dependent aspects of overall renal function. Workshop topics included solute fluxes through ion channels, cotransporters, and metabolically-driven ion pumps; transport across fiber-matrix and capillary membranes; coordinated transport by renal epithelia; the urine concetrating mechanism; and intra-renal hemodynamic control. This volume will be of interest to biological and mathematical scientists who would like a view of recent mathematical efforts to represent membrane transport and its role in renal function.

Download or read book Intermolecular and Surface Forces written by Jacob N. Israelachvili and published by Academic Press. This book was released on 2011-07-22 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermolecular and Surface Forces describes the role of various intermolecular and interparticle forces in determining the properties of simple systems such as gases, liquids and solids, with a special focus on more complex colloidal, polymeric and biological systems. The book provides a thorough foundation in theories and concepts of intermolecular forces, allowing researchers and students to recognize which forces are important in any particular system, as well as how to control these forces. This third edition is expanded into three sections and contains five new chapters over the previous edition. - Starts from the basics and builds up to more complex systems - Covers all aspects of intermolecular and interparticle forces both at the fundamental and applied levels - Multidisciplinary approach: bringing together and unifying phenomena from different fields - This new edition has an expanded Part III and new chapters on non-equilibrium (dynamic) interactions, and tribology (friction forces)

Download or read book The Molecular Basis of Genetic Disorders Associated with Essential Elements Metabolism written by Rajendra Prasad and published by Cambridge Scholars Publishing. This book was released on 2024-02-26 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pioneering book offers a distinctive exploration of a previously uncharted realm; the book effectively amalgamates the fields of biochemistry, molecular biology, and molecular genetics concerning essential element-related genetic disorders, employing a coherent and logical approach. The result is a comprehensive guide to essential metals metabolism, covering their regulation, functions, and corresponding genetic disorders. It serves as an authoritative guide for a diverse audience, including medical students, medical nutritionists, medical geneticists, and basic medical scientists. This innovative perspective is particularly pertinent in an age where interdisciplinary collaboration is essential for comprehensive patient care and medical practice. By fostering a practice-centred approach in clinical medicine, the book will inspire clinicians to embrace a holistic viewpoint. Simultaneously, it beckons basic medical scientists to delve into the enigmatic domain of genetic disorders associated with essential elements.

Download or read book Biophysics written by Rodney Cotterill and published by John Wiley & Sons. This book was released on 2003-07-07 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is an evolving, multidisciplinary subject which applies physics to biological systems and promotes an understanding of their physical properties and behaviour. Biophysics: An Introduction, is a concise balanced introduction to this subject. Written in an accessible and readable style, the book takes a fresh, modern approach with the author successfully combining key concepts and theory with relevant applications and examples drawn from the field as a whole. Beginning with a brief introduction to the origins of biophysics, the book takes the reader through successive levels of complexity, from atoms to molecules, structures, systems and ultimately to the behaviour of organisms. The book also includes extensive coverage of biopolymers, biomembranes, biological energy, and nervous systems. The text not only explores basic ideas, but also discusses recent developments, such as protein folding, DNA/RNA conformations, molecular motors, optical tweezers and the biological origins of consciousness and intelligence. Biophysics: An Introduction * Is a carefully structured introduction to biological and medical physics * Provides exercises at the end of each chapter to encourage student understanding Assuming little biological or medical knowledge, this book is invaluable to undergraduate students in physics, biophysics and medical physics. The book is also useful for graduate students and researchers looking for a broad introduction to the subject.

Download or read book Cell Biology E Book written by Thomas D. Pollard and published by Elsevier Health Sciences. This book was released on 2007-04-26 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: A masterful introduction to the cell biology that you need to know! This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. You'll progress from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. The exquisite art program helps you to better visualize molecular structures. Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject. Makes cell biology easier to understand by demonstrating how cellular structure, function, and dysfunction result from specific macromole¬cular interactions. Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. Helps you to visualize molecular structures and functions with over 1500 remarkable full-color illustrations that present physical structures to scale. Explains how molecular and cellular structures evolved in different organisms. Shows how molecular changes lead to the development of diseases through numerous Clinical Examples throughout. Includes STUDENT CONSULT access at no additional charge, enabling you to consult the textbook online, anywhere you go · perform quick searches · add your own notes and bookmarks · follow Integration Links to related bonus content from other STUDENT CONSULT titles—to help you see the connections between diverse disciplines · test your knowledge with multiple-choice review questions · and more! New keystone chapter on the origin and evolution of life on earth probably the best explanation of evolution for cell biologists available! Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute in San Diego. 200 new and 500 revised figures bring his keen insight to Cell Biology illustration and further aid the reader’s understanding. New chapters and sections on the most dynamic areas of cell biology - Organelles and membrane traffic by Jennifer Lippincott-Schwartz; RNA processing (including RNAi) by David Tollervey., updates on stem cells and DNA Repair. ,More readable than ever. Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms. New guide to figures featuring specific organisms and specialized cells paired with a list of all of the figures showing these organisms. Permits easy review of cellular and molecular mechanisms. New glossary with one-stop definitions of over 1000 of the most important terms in cell biology.

Download or read book Cilia Part B written by and published by Academic Press. This book was released on 2013-03-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cilia and includes chapters on such topics as methods for studying ciliary polarity in Xenopus, analysis of signaling pathways in mammalian spermatozoa, and biochemical and physiological analysis of axonemal dyneins. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers cilia - Contains chapters on such topics as methods for studying ciliary polarity in Xenopus, analysis of signaling pathways in mammalian spermatozoa, and biochemical and physiological analysis of axonemal dyneins

Download or read book Annual Review of Plant Physiology and Plant Molecular Biology written by and published by . This book was released on 1995 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Organophosphorus Chemistry written by David W Allen and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organophosphorus Chemistry provides a comprehensive annual review of the literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa-coordinated compounds, tervalent phosphorus acids, nucleotides and nucleic acids, ylides and related compounds, and phosphazenes. The series will be of value to research workers in universities, government and industrial research organisations, whose work involves the use of organophosphorus compounds. It provides a concise but comprehensive survey of a vast field of study with a wide variety of applications, enabling the reader to rapidly keep abreast of the latest developments in their specialist areas. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Download or read book Triple Helical Nucleic Acids written by Valery N. Soyfer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Download or read book Blood Cell written by Terry E. Moschandreou and published by BoD – Books on Demand. This book was released on 2012-09-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor has incorporated scientific contributions from a diverse group of leading researchers in the field of hematology and related blood cell research. This book aims to provide an overview of current knowledge pertaining to our understanding of hematology. The main subject areas will include blood cell morphology and function, the pathophysiology and genetics of hematological disorders and malignancies, blood testing and typing, and the processes governing hematopoiesis. Blood cell physiology, biochemistry and blood flow are covered in this book. This text is designed for hematologists, pathologists and laboratory staff in training and in practice. The work presented in this book will be of benefit to medical students and to researchers of hematology and blood flow in the microcirculation.This book is written primarily for those who have some knowledge of chemistry, biochemistry and general hematology. The authors of each section bring a strong clinical emphasis to the book.

Download or read book Microfluidic Devices for Biomedical Applications written by Xiujun (James) Li and published by Woodhead Publishing. This book was released on 2021-08-05 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. - Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications - Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies - Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering

Download or read book Annual Review of Plant Physiology and Plant Molecular Biology written by Russell L. Jones and published by Annual Reviews. This book was released on 1995-06 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Darwin s Black Box written by Michael J. Behe and published by Simon and Schuster. This book was released on 1996 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behe argues that the complexity of cellular biochemistry argues against Darwin's gradual evolution.

Download or read book Comprehensive Nanoscience and Technology written by and published by Academic Press. This book was released on 2010-10-29 with total page 2785 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Introduction: Nanotechnology and its underpinning sciences are progressing with unprecedented rapidity. With technical advances in a variety of nanoscale fabrication and manipulation technologies, the whole topical area is maturing into a vibrant field that is generating new scientific research and a burgeoning range of commercial applications, with an annual market already at the trillion dollar threshold. The means of fabricating and controlling matter on the nanoscale afford striking and unprecedented opportunities to exploit a variety of exotic phenomena such as quantum, nanophotonic and nanoelectromechanical effects. Moreover, researchers are elucidating new perspectives on the electronic and optical properties of matter because of the way that nanoscale materials bridge the disparate theories describing molecules and bulk matter. Surface phenomena also gain a greatly increased significance; even the well-known link between chemical reactivity and surface-to-volume ratio becomes a major determinant of physical properties, when it operates over nanoscale dimensions. Against this background, this comprehensive work is designed to address the need for a dynamic, authoritative and readily accessible source of information, capturing the full breadth of the subject. Its six volumes, covering a broad spectrum of disciplines including material sciences, chemistry, physics and life sciences, have been written and edited by an outstanding team of international experts. Addressing an extensive, cross-disciplinary audience, each chapter aims to cover key developments in a scholarly, readable and critical style, providing an indispensible first point of entry to the literature for scientists and technologists from interdisciplinary fields. The work focuses on the major classes of nanomaterials in terms of their synthesis, structure and applications, reviewing nanomaterials and their respective technologies in well-structured and comprehensive articles with extensive cross-references. It has been a constant surprise and delight to have found, amongst the rapidly escalating number who work in nanoscience and technology, so many highly esteemed authors willing to contribute. Sharing our anticipation of a major addition to the literature, they have also captured the excitement of the field itself in each carefully crafted chapter. Along with our painstaking and meticulous volume editors, full credit for the success of this enterprise must go to these individuals, together with our thanks for (largely) adhering to the given deadlines. Lastly, we record our sincere thanks and appreciation for the skills and professionalism of the numerous Elsevier staff who have been involved in this project, notably Fiona Geraghty, Megan Palmer and Greg Harris, and especially Donna De Weerd-Wilson who has steered it through from its inception. We have greatly enjoyed working with them all, as we have with each other.

Download or read book Recombinant DNA Technology written by Keya Chaudhuri and published by The Energy and Resources Institute (TERI). This book was released on 2013-01-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant DNA Technology is focussed on the current state of knowledge on the recombinant DNA technology and its applications. The book will provide comprehensive knowledge on the principles and concepts of recombinant DNA technology or genetic engineering, protein expression of cloned genes, PCR amplification of DNA, RFLP, AFLP and DNA fingerprinting and finally the most recent siRNA technology. It can be used by post-graduate students studying and teachers teaching in the area of Molecular Biology, Biotechnology, Genetics, Microbiology, Life Science, Pharmacy, Agriculture and Basic Medical Sciences.