Download or read book Animal models in dermatology written by Howard I. Maibach and published by . This book was released on 1975 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Animal Models in Dermatology Relevance to Human Dermatopharmacology and Dermatotoxicology written by Howard I. Maibach and published by . This book was released on with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Animal Models in Dermatology written by Howard I. Maibach and published by . This book was released on 1975 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Animal Models in Dermatology Relevance to Human Dermatopharmacology and Dermatotoxicology a symposium held in San Francisco CA September 1974 written by Maibach H Ed and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Skin Pharmacology and Toxicology written by Corrado L. Galli and published by Springer. This book was released on 1990 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1979 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes subject section, name section, and 1968-1970, technical reports.
Download or read book Principles of Animal Extrapolation 1991 written by Edward J. Calabrese and published by CRC Press. This book was released on 2017-11-22 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.
Download or read book Models in Dermatology Dermatopharmacology and toxicology written by and published by . This book was released on 1985 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dermal Absorption Models in Toxicology and Pharmacology written by Jim E. Riviere and published by CRC Press. This book was released on 2005-08-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Download or read book Report of the Carcinogenesis Program written by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention and published by . This book was released on 1975 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Trichothecene Mycotoxicosis Pathophysiologic Effects 1989 written by Val Richard Beasley and published by CRC Press. This book was released on 2017-11-22 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are instances of unresolved differences of opinion , as in the case of underlying biochemical mechanisms of action. It has been particularly challenging to interpret the diversity of effects induced by several trichothecenes when studied in various cells, tissues, and concentrations, and at dissimilar intervals. In the hope of shortening the time needed to overcome these difficulties, the authors have sought to discuss a range of observations delineating both areas of agreement and aspects remaining to be clarified. The final chapter of the volumes is comprised of an effort to integrate the various observations detailed throughout the book. With the continued efforts of not only the many dedicated scientists who served as contributors to these volumes, but from the many other authors cited herein and those to follow, out understanding of these interesting compounds will continue to expand. We have already learned enough to greatly reduce the adverse effects of the trichothecene mycotoxins on humans and other animals.
Download or read book Percutaneous Absorption written by Nina Dragićević and published by CRC Press. This book was released on 2021-07-30 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
Download or read book Occupational Safety and Health Research and Demonstration Grants written by National Institute for Occupational Safety and Health. Office of Extramural Activities and published by . This book was released on 1977 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index of Conference Proceedings Received written by and published by . This book was released on 1975 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Report of the Carcinogenesis Program Fiscal Year 1975 written by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention and published by . This book was released on 1975 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinoids written by C.E. Orfanos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.
Download or read book Report of the Carcinogenesis Program Fiscal Year 1976 written by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention and published by . This book was released on 1976 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
