Download or read book Animal friendly methods for rodent behavioral testing in neuroscience research written by Raffaele d’Isa and published by Frontiers Media SA. This book was released on 2024-07-03 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly challenging the psychological welfare of the model animals. On the other hand, tests based on rewards, which apparently may seem more ethical, actually still induce suffering in the animals, as food rewards are almost always associated with a food restriction protocol, in order to motivate food-seeking behavior. Rodents are starved for days before starting the test and kept under food restriction for the whole duration of the test. The distress during the testing session is only a minimal part compared to the stress lived outside of the testing session, which is prolonged and continuous. Analogously, liquid rewards commonly rely on a previous water restriction protocol to use thirst as motivation. Animal stress is not only an ethical issue per se, but also an important factor potentially impacting on the reliability and reproducibility of experimental results.
Download or read book Mouse Behavioral Testing written by Douglas Wahlsten and published by Academic Press. This book was released on 2010-11-25 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book A Researcher s Guide to Rodent Behavior written by Robert M.J. Deacon and published by Academic Press. This book was released on 2024-03-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Researcher's Guide to Rodent Behavior: Experimental Designs, Methods and Protocols, Volume 32 provides a comprehensive guide to all forms of behavioral processes found in mice, rats and other rodents used in behavioral and cognitive research. Sections discuss basic skills necessary for successful rodent behavior research, including experimental design, animal selection, building any necessary apparatus, ethical considerations and interpretation of results. The book provides useful guidance for researchers at all stages of their careers, including a detailed description of how to perform stereotaxic surgery on the rat or mouse brain, advice on how to non-appetitively motivate rodents, and more. Most significantly, the book contains 35 proven, clearly defined protocols to aid readers in their research, making it one of the few books available that provides a collection of such protocols in a single publication. The cognitive, motor, sensory, affective, and species-typical protocols are profusely illustrated with full-color photographs from the author's own research, to help readers more fully understand the studies and methods discussed in the text and provide further instruction on the ideal ways to re-create research projects themselves.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book The Behavior of the Laboratory Rat written by Ian Q. Whishaw and published by Oxford University Press. This book was released on 2004-09-02 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both seasoned and beginning investigators will be amazed at the range and complexity of rat behavior as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing the investigator to exploit both the behavior and the methods for their own research. It will also serve as an indispensable reference for other neuroscientists, psychologist, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees.
Download or read book Animal Models of Behavioral Analysis written by Jacob Raber and published by Humana Press. This book was released on 2010-10-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the difficulty in comparing clinic-based human tests with animal model testing, there is still great value in pursuing translational approaches, as tests and treatment strategies might be developed to improve brain function in humans suffering from neurological conditions and knowledge obtained from human behavioral studies can be used to further improve the animal models of behavioral analysis. In Animal Models of Behavioral Analysis, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans not only to increase our understanding of brain function across species but also to provide objective performance measures and bridge the gap between behavioral alterations in humans with cognitive disorders and the correlating animal models of these conditions. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Provocative and cutting-edge, Animal Models of Behavioral Analysis seeks to aid researchers in further developing these vital techniques in an effort to advance studies in both the clinic and the laboratory.
Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Download or read book What s Wrong With My Mouse written by Jacqueline N. Crawley and published by John Wiley & Sons. This book was released on 2007-05-11 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Download or read book Methods and Welfare Considerations in Behavioral Research with Animals written by and published by . This book was released on 2002 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Social Behavior from Rodents to Humans written by Markus Wöhr and published by Springer. This book was released on 2017-01-31 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compelling volume provides a broad and accessible overview on the rapidly developing field of social neuroscience. A major goal of the volume is to integrate research findings on the neural basis of social behavior across different levels of analysis from rodent studies on molecular neurobiology to behavioral neuroscience to fMRI imaging data on human social behavior.
Download or read book Animal Experimentation Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutical industry. The materials presented draw from the scholarly works of recognized experts in several fields of cognitive and behavioral neuroscience. Each contributor describes the most frequently used and most widely accepted version of the model, and each chapter includes: (1) a well-referenced introduction that covers the theory behind and the utility of the model; (2) a detailed and step-by-step methodology; and (3) an approach to the interpretation of the data presented. Many chapters also provide examples of actual experiments that use the method. This text eliminates the guesswork from the process of designing the methodology for many of the animal behavioral models that are used to study brain disorders, drug abuse, toxicology, and cognitive drug development. It will also significantly reduce the time spent assessing literature and developing models for studying animal subjects. Overall, Methods of Behavioral Analysis in Neuroscience is an invaluable reference source for the professional who seeks to comprehend the effects of disease on human cognition.
Download or read book Rodent Model as Tools in Ethical Biomedical Research written by Monica Levy Andersen and published by Springer. This book was released on 2015-11-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.
Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Download or read book Mood and Anxiety Related Phenotypes in Mice written by Todd D Gould and published by Humana Press. This book was released on 2012-03-07 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.
Download or read book Rodent Model as Tools in Ethical Biomedical Research written by Monica Levy Andersen and published by Springer. This book was released on 2015-09-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.
