Download or read book Animal Discoveries written by Tamra Orr and published by Capstone. This book was released on 2019 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imagine a worm that spits glue, a rat with vampire teeth, and a frog you can see through! These are just some of the amazing animals that were recently discovered by scientists. Readers learn about these fascinating creatures and many more through carefully-leveled, engaging books reviewed by Smithsonian experts.
Download or read book Animals Underground written by Claude Delafosse and published by My First Discoveries. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet the animals who live in darkness underground, safe from other animals who want to eat them.
Download or read book Stuff They Don t Want You to Know written by Ben Bowlin and published by Flatiron Books. This book was released on 2022-10-11 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Interesting...Bowlin's calmly rational approach to the subject of conspiracy theories shows the importance of logic and evidence.”—Booklist "A page-turning book to give to someone who believes in pizza pedophilia or that the Illuminati rule the world."—Kirkus Reviews The co-hosts of the hit podcast Stuff They Don’t Want You to Know, Ben Bowlin, Matthew Frederick, & Noel Brown, discern conspiracy fact from fiction in this sharp, humorous, compulsively readable, and gorgeously illustrated book. In times of chaos and uncertainty, when trust is low and economic disparity is high, when political institutions are crumbling and cultural animosities are building, conspiracy theories find fertile ground. Many are wild, most are untrue, a few are hard to ignore, but all of them share one vital trait: there’s a seed of truth at their center. That seed carries the sordid, conspiracy-riddled history of our institutions and corporations woven into its DNA. Ben Bowlin, Matt Frederick, and Noel Brown host the popular iHeart Media podcast, Stuff They Don’t Want You To Know. They are experts at exploring, explaining, and interrogating today’s emergent conspiracies—from chem trails and biological testing to the secrets of lobbying and the indisputable evidence of UFOs. Written in a smart, witty, and conversational style, elevated with amazing illustrations, Stuff They Don’t Want You to Know is a vital book in understanding the nature of conspiracy and using truth as a powerful weapon against ignorance, misinformation, and lies.
Download or read book Spillover Animal Infections and the Next Human Pandemic written by David Quammen and published by W. W. Norton & Company. This book was released on 2012-10 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: A masterpiece of science reporting that tracks the animal origins of emerginghuman diseases.
Download or read book Animal Evolution written by Claus Nielsen and published by Oxford University Press on Demand. This book was released on 2012 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using modern phylogenetic reasoning based on an extensive review of morphology, including ultrastructure, and embryology, each phylum is analysed to ascertain its monophyly and hence its ancestral characters.
Download or read book Animal Social Networks written by Jens Krause and published by OUP Oxford. This book was released on 2014-12-18 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific study of networks - computer, social, and biological - has received an enormous amount of interest in recent years. However, the network approach has been applied to the field of animal behaviour relatively late compared to many other biological disciplines. Understanding social network structure is of great importance for biologists since the structural characteristics of any network will affect its constituent members and influence a range of diverse behaviours. These include finding and choosing a sexual partner, developing and maintaining cooperative relationships, and engaging in foraging and anti-predator behavior. This novel text provides an overview of the insights that network analysis has provided into major biological processes, and how it has enhanced our understanding of the social organisation of several important taxonomic groups. It brings together researchers from a wide range of disciplines with the aim of providing both an overview of the power of the network approach for understanding patterns and process in animal populations, as well as outlining how current methodological constraints and challenges can be overcome. Animal Social Networks is principally aimed at graduate level students and researchers in the fields of ecology, zoology, animal behaviour, and evolutionary biology but will also be of interest to social scientists.
Download or read book Tushes Tails written by Stéphane Frattini and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invites readers to guess which animal is featured on each page and learn fascinating facts about it.
Download or read book Encyclopedia of the World s Biomes written by and published by Elsevier. This book was released on 2020-06-26 with total page 3542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of the World’s Biomes is a unique, five volume reference that provides a global synthesis of biomes, including the latest science. All of the book's chapters follow a common thematic order that spans biodiversity importance, principal anthropogenic stressors and trends, changing climatic conditions, and conservation strategies for maintaining biomes in an increasingly human-dominated world. This work is a one-stop shop that gives users access to up-to-date, informative articles that go deeper in content than any currently available publication. Offers students and researchers a one-stop shop for information currently only available in scattered or non-technical sources Authored and edited by top scientists in the field Concisely written to guide the reader though the topic Includes meaningful illustrations and suggests further reading for those needing more specific information
Download or read book Animal Social Networks written by Dr. Jens Krause and published by Oxford University Press. This book was released on 2015 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific study of networks - computer, social, and biological - has received an enormous amount of interest in recent years. However, the network approach has been applied to the field of animal behaviour relatively late compared to many other biological disciplines. Understanding social network structure is of great importance for biologists since the structural characteristics of any network will affect its constituent members and influence a range of diverse behaviours. These include finding and choosing a sexual partner, developing and maintaining cooperative relationships, and engaging in foraging and anti-predator behavior. This novel text provides an overview of the insights that network analysis has provided into major biological processes, and how it has enhanced our understanding of the social organisation of several important taxonomic groups. It brings together researchers from a wide range of disciplines with the aim of providing both an overview of the power of the network approach for understanding patterns and process in animal populations, as well as outlining how current methodological constraints and challenges can be overcome. Animal Social Networks is principally aimed at graduate level students and researchers in the fields of ecology, zoology, animal behaviour, and evolutionary biology but will also be of interest to social scientists.
Download or read book American Alligator written by Kelby Ouchley and published by University Press of Florida. This book was released on 2013-10-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Having survived since the Mesozoic era, alligators teetered on the brink of extinction in the 1960s. Their recovery in the 1970s was largely due to legislative intervention, and today populations are closely monitored throughout their range. American Alligator is the most up-to-date and comprehensive treatment of this resilient relic, a creature with a brain weighing less than half an ounce that has successfully adapted to a changing Earth for more than 200 million years. Kelby Ouchley chronicles the evolution of A. mississippiensis from "shieldcroc"--the last common ancestor of modern-day alligators, crocodiles, caimans, and gavials--to its current role as keystone of the ecological health of America's southern swamps and marshes. In Florida, the apex predator uses its snout and feet to clear muck from holes in the limestone bedrock. During the dry season, these small ponds or "alligator holes" provide refuge, food, and water for a variety of wildlife. In Louisiana, millions of dollars are spent on the bounty of the non-native nutria that overgraze marsh vegetation, but alligators prey on these coastal rodents free of charge. The loss of the American alligator would be a blow to biodiversity and an ecosystem disruption affecting all levels of the food chain. While the U.S. Fish and Wildlife Service removed it from the endangered species list in 1987 and today regulates the legal trade of the animal and its products, Ouchley cautions us not to forget the lessons learned: human activities, from urban development to energy production, can still threaten the future of the gator and its southern wetland habitat.
Download or read book The Lost Species written by Christopher Kemp and published by University of Chicago Press. This book was released on 2020-11-25 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: We hear routinely about dinosaurs unearthed in the Gobi Desert, about new marsupials found in the forests of Madagascar, about darling deep sea squid in the polar regions. These discoveries tend to be accompanied by wondrous feats of adventuring scientists. But just as one can experience the world in a backyard, or farther reaches of the world with a good book and a comfy armchair, scientists themselves know that the natural history museums of the world contain some of the best terrain for discovering new species. In recent years scientists have found in museum drawers and cabinets a new rove beetle collected by Darwin, a tiny lungless salamander thinner than a matchstick, a monkey from the Brazilian rainforest, and a 40 million year old beardog. The Lost Species shares the thrill of spelunking in museum basements, digging in museum trays, and breathing new life in taxidermied beings--a in a days' adventure for the scientists in this book. These discoveries help tell the story of life, and the priceless collections of natural history museums.
Download or read book Modern CNS Drug Discovery written by Rudy Schreiber and published by Springer Nature. This book was released on 2021-06-17 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.
Download or read book Drug Discovery and Evaluation Safety and Pharmacokinetic Assays written by Franz J. Hock and published by Springer Nature. This book was released on 2025-02 with total page 2751 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.
Download or read book In vivo Models for Drug Discovery written by José Miguel Vela and published by John Wiley & Sons. This book was released on 2014-07-31 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.
Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Download or read book Animal Biodiversity and Conservation in Brazil s Northern Atlantic Forest written by Gentil Alves Pereira Filho and published by Springer Nature. This book was released on 2023-04-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fauna of the Pernambuco Endemism Center in Brazil's Northern Atlantic Forest, an understudied global biodiversity hotspot. Through fifteen curated chapters, it provides the latest information about the fauna of the northern portion of the Atlantic Forest, gathering important information about the faunal composition of the region for the first time. The chapters address animal biodiversity including terrestrial and aquatic vertebrates (fish, amphibians, reptiles, birds, and mammals) and invertebrates (ants, butterflies, dung beetles, hervestmen, spiders, and termites). All chapters provide species lists, taxonomic aspects and richness analysis. Conservation of specific animal groups is also discussed. Finally, the book discusses human impacts on the forest and its biodiversity, emphasizing the need for conservation of this highly impacted ecosystem.
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
