Download or read book Androgen Action in Prostate Cancer written by Donald Tindall and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

Download or read book Androgen Action in Prostate Cancer written by Donald J. Tindall and published by Springer. This book was released on 2009-05-15 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

Download or read book STACS 93 written by Patrice Enjalbert and published by Springer Verlag. This book was released on 1993 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume contains the proceedings of the tenth annual Symposium on Theoretical Aspects of Computer Science (STACS '93), held in W}rzburg, February 25-27, 1993. The STACS symposia are held alternately in Germany and France, and organized jointly by the Special Interest Group for Theoretical Computer Science of the Gesellschaft f}r Informatik (GI) and theSpecial Interest Group for Applied Mathematics of the Association Francaise des Sciences et Technologies de l'Information et des Syst mes (afcet). The volume includes the three invited talks which opened the three days of the symposium: "Causal and distributed semantics for concurrent processes" (I. Castellani), "Parallel architectures: design and efficient use" (B. Monien et al.), and "Transparent proofs" (L. Babai). The selection of contributed papers is organized into parts on: computational complexity, logic in computer science, efficient algorithms, parallel and distributed computation, language theory, computational geometry, automata theory, semantics and logic of programming languages, automata theory and logic, circuit complexity, omega-automata, non-classical complexity, learning theory and cryptography, and systems."--PUBLISHER'S WEBSITE.

Download or read book Androgen Action written by Fahri Saatcioglu and published by Humana Press. This book was released on 2011-08-04 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

Download or read book Androgen Responsive Genes in Prostate Cancer written by Zhou Wang and published by Springer Science & Business Media. This book was released on 2013-02-16 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.​

Download or read book Testosterone written by Susan Nieschlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.

Download or read book Androgens and Androgen Receptor written by Chawnshang Chang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include: -The discovery and cloning of the androgen receptor; -Androgen receptor coregulators; -Androgen related genes and their consensus DNA response elements; -Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; -Cross-talk to other signal transduction systems; -The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer. This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Download or read book Prostate Cancer written by Zoran Culig and published by Humana Press. This book was released on 2018-05-22 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents methods and protocols on modern analysis of steroid receptor and prostate cancer function. Chapters detail androgen, androgen receptor action, anti-androgen enzalutamide, in vitro and in vivo models, imaging, gene fusions, and help facilitate studies with novel drugs including anti-androgens and chemotherapeutics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Prostate Cancer: Methods and Protocols aims to provide easily reproducible techniques.

Download or read book AR Signaling in Human Malignancies Prostate Cancer and Beyond written by Emmanuel S. Antonarakis and published by MDPI. This book was released on 2018-03-23 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "AR Signaling in Human Malignancies: Prostate Cancer and Beyond" that was published in Cancers

Download or read book Advances in Rapid Sex Steroid Action written by Gabriella Castoria and published by Springer Science & Business Media. This book was released on 2011-12-15 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

Download or read book Androgen Deprivation Therapy written by Richard J. Wassersug, PhD and published by Springer Publishing Company. This book was released on 2021-07-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Androgen Deprivation Therapy: "To my knowledge [this] is the only book written in plain language (no medical jargon) explaining what’s happening during ADT, and detailing how to limit and often solve most associated side effects. It should be read by every man undergoing ADT, as well as family members and also healthcare providers. They will find all the details they need to get the most from this treatment..." Prof. N. Mottet, MD, PhD, Urologist, Medical Oncologist, Head of the Prostate Cancer Guidelines panel of the European Association of Urology Androgen Deprivation Therapy is the only guide written exclusively about the side effects of hormone therapy. The authors have collaborated with the European Association of Urology to produce this specially revised new edition to serve men affected by ADT across the globe. This comprehensive workbook for prostate cancer patients and their loved ones is filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their lives that can keep them healthy and positive when the patient is on ADT. New to this Edition: Updates on the physical side effects of ADT and management strategies Expanded information on exercise and nutrition for men diagnosed with prostate cancer Updates on the primary drugs used to treat prostate cancer and extensive drug tables with common brand names worldwide Revisions throughout based on critical feedback from international medical experts in the field of prostate cancer and related disciplines Exercises, activities, worksheets, and other tools to promote discussion and inspire behavioural changes that can reduce the burden of ADT Officially endorsed by the European Association of Urology

Download or read book The Mechanism of Action of Androgens written by W.I.P. Mainwaring and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.

Download or read book Response and Resistance in Castration Resistant Prostate Cancer written by Hung-Ming Lam and published by Frontiers Media SA. This book was released on 2020-12-24 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance written by Andrew Freywald and published by Academic Press. This book was released on 2020-12-02 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Download or read book Androgen Deprivation Therapy written by John W. Robinson, PhD, R Psych and published by Demos Medical Publishing. This book was released on 2014-06-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is an excellent resource for individuals who are both being treated by and caring for those on androgen deprivation therapy. It addresses commonly understood as well as sensitive topics impacted by this treatment and offers explanations and strategies for how to address and cope with these side effects. Its interactive activities, patient testimonials, and annotations encourage readers to study the topics so that they will better understand the issues. In all, it is a superb source of knowledge for these patients and their families and caregivers."--Doody's Book Review Service Successfully manage the side effects of androgen deprivation therapy (ADT) and get back to life For many men with prostate cancer, ADT (sometimes referred to as hormone therapy) offers hope for controlling the disease and living longer. But the side effects can leave you with unexpected physical and emotional changes. In Androgen Deprivation Therapy, experts who have helped hundreds of men provide you and your loved ones with the tools and solutions you need to prepare for treatment and deal with every situation. You'll learn how to: Reduce hot flashes and night sweats Address changes in weight and body composition Maintain sexual intimacy despite changes in libido Fight fatigue and insomnia Control mood swings and depression Maintain open communication with your partner

Download or read book Androgen Deprivation Therapy Second Edition written by Richard J. Wassersug, PhD and published by Springer Publishing Company. This book was released on 2018-06-28 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Androgen Deprivation Therapy: "Every man who is a candidate for ADT needs to read this outstanding book.” –Patrick C. Walsh, MD, University Distinguished Service Professor of Urology, The Johns Hopkins Medical Institution “This new and updated second edition will again be an important and valuable resource for the vast majority of men who are faced with the need to start ADT for treatment of progressive and advanced forms of prostate cancer – whether for a few months or for the rest of their lives. It is a book we will again recommend to patients when they ask us about issues related to life on ADT.” —E. Michael D. (“Mike”) Scott Co-Founder and President Prostate Cancer International This expanded new edition of Androgen Deprivation Therapy remains the only guide written exclusively about the side effects of hormone therapy. This is a comprehensive workbook for prostate cancer patients and their loved ones, filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their own lives that can keep them healthy and positive when the patient is on ADT. New to this Edition: Updates to every chapter, including an extensive update on the various drugs used for androgen deprivation Suggestions for managing the physical side effects of ADT, such as hot flashes, weight gain, muscle loss, and fatigue Strategies to handle the emotional side effects, including coping with mood swings and depression Advice on how to maintain intimacy despite reduced libido and difficulties with erections A new chapter on the psychological and relational impact of ADT on gay men Exercises, activities, worksheets, and other tools to promote discussion and inspire sustainable behavioral changes that can reduce the burden of ADT

Download or read book Precision Molecular Pathology of Prostate Cancer written by Brian D. Robinson and published by Springer. This book was released on 2018-02-13 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.