Download or read book Analysis of the Human Immune Response Against the Merozoite Surface Protein MSP 1 from Plasmodium Falciparum a Malaria Vaccine Candidate written by Anja Jäschke and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders
Download or read book Human Immune Responses to the C terminus of the Malaria Vaccine Candidate Antigen the Major Merozoite Surface Protein of Plasmodium Falciparum PfMSP1 written by Andréa Egan and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Mediated Immune Responses to the Plasmodium Falciparum Asexual Stage Vaccine Candidate Merozoite Surface Protein 1 MSP1 written by Anne Ellizabeth Smillie and published by . This book was released on 2002 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.
Download or read book Immunity to Malaria and Vaccine Strategies written by Kevin N. Couper and published by Frontiers Media SA. This book was released on 2019-10-10 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at increased risk of severe malarial disease when protection wanes. Thus, to define new ways to combat malaria, there remains an urgent requirement to identify the immune mechanisms that promote resistance to malarial disease and to understand why these so often fail. The review and primary research articles in this Research Topic illustrate the breadth of research performed worldwide aimed to understand the biology of the Plasmodium parasite, the roles of the various cell types that act within the immune response against the parasite, and the parasitological and immunological basis of severe malarial disease. The articles in section 1 exemplify the different vaccination strategies being developed and tested by the research community in the fight against malaria. The articles in section 2 review important overarching aspects of malaria immunology and the use of models to study human malaria. The articles in section 3 describe the ways through which the Plasmodium parasite is initially recognised by the immune system during infection, how the parasite can directly impact this critical event to restrict anti-Plasmodial immunity, and resolve the roles of key innate cell populations, such as dendritic cells, in coordinating malarial immunity. The articles in sections 4-6 outline the roles T and B cell populations play during malaria, highlighting the activation, diversification and regulation of the crucial cell types during malaria, and discuss some of the reasons adaptive immunity to malaria is often considered so poor compared with other diseases. The articles in section 7 provide up to date information on the pathogenesis of cerebral malaria, bridging our understanding of the syndrome in humans with information learned from animal models. Overall, the articles in this research, many of which are published by leaders in the malaria field, emphasize the imagination and technical advances being employed by researchers against malaria. We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
Download or read book Falciparum Malaria New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Falciparum Malaria: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Falciparum Malaria in a concise format. The editors have built Falciparum Malaria: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Falciparum Malaria in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Falciparum Malaria: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Immune Response to Plasmodium Falciparum Merozoite Protein 2 written by Afra Khosravi and published by LAP Lambert Academic Publishing. This book was released on 2012-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Merozoite surface protein is a promising vaccine candidate of malaria on which many cross-sectional or longitudinal research has been done so far.The Antibody to a merozoite surface antigen-2 of plasmodium falciparum malaria is age dependent and mostly against the central variable domains of this antigen so called domains 2 and 3. such Immunity can lead to a protective response against the severe form of malaria disease.
Download or read book Rodent Malaria written by R. Killick-Kendrick and published by Elsevier. This book was released on 2012-12-02 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rodent Malaria reviews significant findings concerning malaria parasites of rodents, including their taxonomy, zoogeography, and evolution, along with life cycles and morphology; genetics and biochemistry; and concomitant infections. This volume is organized into eight chapters and begins by sketching out the history of the discovery of rodent as well as aspects of parasitology, immunology, and chemotherapy. These concepts are investigated two decades following Ignace Vincke's major discovery and Meir Yoeli's successful establishment of the method of cyclical transmission of the parasite. The following chapters focus on the taxonomy and systematics of the subgenus Vinckeia, with reference to the concepts of species and subspecies of animals and the degree to which they apply to malaria parasites, in particular to those of rodents. The discussion then shifts to how the rodent malaria parasites provide a unique insight into the subcellular organization of Plasmodium species, the use of rodent malaria as an experimental model to study immunological responses, and infectious agents that interact with malaria parasites. The book concludes with a chapter on malaria chemotherapy, with emphasis on the value of rodent malaria in antimalarial drug screening and the use of antimalarial drugs as biological probes. This book will be of interest to protozoologists and physicians as well as those from other disciplines including biochemistry, immunology, pharmacology, cell biology, and genetics.
Download or read book National Institute of Allergy and Infectious Diseases NIH written by Vassil St. Georgiev and published by Springer Science & Business Media. This book was released on 2010-07-29 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research. This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories.
Download or read book Production of a Recombinant E Coli Expressed Malaria Vaccine from the C Terminal Fragment of Piasmodium Falciparum 3D7 Merozoite Surface Protein 1 written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malarial blood stage antigens can produce humoral immunity by induction of protective antibodies to epitopes on surface antigens on parasites. The merozoite surface protein-1 (MSP1) of P. falciparum is a major blood-stage vaccine candidate. MSP1 may play a role in binding and/or infection of erythrocytes by merozoites (parasites) during red blood cell invasion. The C-terminal fragment of MSP1, MSP1(sub 19), is highly conserved among all known strains of P. falciparum. immunization with recombinant proteins that have native-like conformations may elicit long-lasting protective immunity that mimics the natural immunity. We have used bacterial expression to tightly regulate transcription and translation of MSP1(sub 42). Plasmids that encode MSP1(sub 42) were prepared and tested for their ability to express recombinant protein. A three column purification scheme that included Ni(+2) metal chelate chromatography, anion and then cation exchange chromatography, yielded greater than 95% pure MSP1(sub 42). Immunoreactivity with mAbs showed that recombinant MSP1(sub 42) was conformationally similar to native MSP1. The objectives were to develop recombinant MSP1(sub 42) molecules that were structurally correct, to develop fermentation and purification processes that could be scaled-up for large-scale processes, and ultimately, to advance these products into human clinical trials.
Download or read book Production of a Recombinant E Coli Expressed Malarial Vaccine from the C Terminal Fragment of Plasmodium Falciparum 3D7 Merozoite Surface Protein 1 written by and published by . This book was released on 2000 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: P. falciparum Merozoite Surface Protein-1 (MSP-1) is a leading erythrocytic stage vaccine candidate. Following secondary proteolytic processing, it may play a role in binding and/or invasion of erythrocytes. The secondary processing gives a 33kD and 19kD fragment. The MSP1-19 is a target for parasite inhibitory antibodies and protective immunity. However, it appears to lack T-helper epitopes. Since antibody is likely the effector mechanism induced by MSP1-19, it is important to insure that recombinant vaccines based on this antigen be folded correctly and contain T-helper epitopes that will enhance induction of humoral responses. We have developed recombinant MSP1-42 molecules that are structurally correct based on positive reactivities with conformation-dependent mAbs. These proteins have been produced to greater than 95% purity and exceed FDA endotoxin standards. Immunogenicity studies in mice and Rhesus monkeys reveal that good antibody responses are induced to MSP1-42 when these animals are immunized with the MSP1-42 plus SBAS2 adjuvant.
Download or read book Malaria Parasites written by Omolade Okwa and published by BoD – Books on Demand. This book was released on 2012-03-30 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a global disease in the world today but most common in the poorest countries of the world, with 90% of deaths occurring in sub-Saharan Africa. This book provides information on global efforts made by scientist which cuts across the continents of the world. Concerted efforts such as symbiont based malaria control; new applications in avian malaria studies; development of humanized mice to study P.falciparium (the most virulent species of malaria parasite); and current issues in laboratory diagnosis will support the prompt treatment of malaria. Research is ultimately gaining more grounds in the quest to provide vaccine for the prevention of malaria. The book features research aimed to bring a lasting solution to the malaria problem and what we should be doing now to face malaria, which is definitely useful for health policies in the twenty first century.
Download or read book Puzzle pieces from malaria vaccine clinical trials written by Nirianne Querijero Palacpac and published by Frontiers Media SA. This book was released on 2023-03-02 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
