Download or read book Analysis of the Cellular Processes that Generate Peptides for Major Histocompatibility Complex Class I Molecules written by Thomas Francis Serwold and published by . This book was released on 2000 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Download or read book Antigen Processing and Presentation written by Robert Edward Humphreys and published by . This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Download or read book Immunoinformatics written by Christian Schönbach and published by Springer Science & Business Media. This book was released on 2007-11-21 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.
Download or read book The Impact of HLA DM on Peptide Binding to MHC Class II written by Megan Templeton and published by . This book was released on 2016 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition of peptides bound to class II major histocompatibility complex (MHCII) molecules by T cell receptors of CD4+ T cells initiates an adaptive immune response. Analysis of the antigen presentation pathway indicates that elements of the epitope selection process are critical to generation of the peptide repertoire presented to T cells. Antigen presentation by dedicated cells (APCs) involves the intracellular fragmentation of protein antigens by cathepsins, binding of the derived peptide epitopes to MHCII with the participation of the peptide-editing molecule HLA-DM (DM), and subsequent transport to the surface for recognition. This thesis focuses on the energetics and structural flexibility of the peptide-MHCII complex, and their correlation with DM-susceptibility, to identify the criteria associated with the selection of peptides by APCs for subsequent presentation to T cells. Using the human MHCII HLA-DR (DR), and peptides derived from influenza H3 HA305-318 as test system, it was observed that, in the absence of DM, stable peptide binding is not reached through independent contributions of single-point interactions, but is a distributive process that involves the peptide-DR groove dyad in its entirety highlighting the inherent flexibility of the binding process. Here, DM mechanism is investigated in its ability to impact structural flexibility of the complex. Analysis of release from and binding to DR of a gamut of HA-derived peptides at two different levels of pH reveals that structural stability is reduced as a consequence of DM function. The results indicate that the outcome of DM activity is favoring the endurance of complexes with limited structural flexibility.
Download or read book Kinetic and Structural Analysis of Class II MHC peptide Complexes written by Michael N. Liang and published by . This book was released on 1997 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanism of Peptide Binding to Major Histocompatibility Complex Class I Molecules in the Cellular Context written by Esam Abualrous and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MHC written by Dr. Nelson Fernandez and published by IRL Press. This book was released on 1997 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex is the subject of much research in the immunology field. There is a great deal of interest in the structure of MHC proteins and in their function as antigen presenting molecules. An increasing number of immunology laboratories are preparing to investigatebiochemical and genetic techniques in order to study these molecules. The identification of the peptide transporter genes and the elution of peptides from MHC molecules demonstrate how rapidly our understanding of the structure and function of the MHC locus has advanced. MCH1: A Practical Approachbrings together the technologies which facilitate the advances that are being made. It has detailed explanations of processes such as peptide translocation into the ER, the application of mass spectrometry to the analysis of peptides bound to MHC, and signal detection via MHC class II moleculeswhich can lead to either activation or programmed cell death. This book is a comprehensive and thorough guide to the fast growing and fascinating field of MHC research. Graduates, post doctorial researchers, academic staff and clinicians in the immunology field will find this book an invaluableaid.
Download or read book Peptidomics written by Michael Schrader and published by Humana. This book was released on 2019-06-04 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes protocols for basic state-of-the-art approaches in the field of peptidomics. Most of these approaches are independent of the instruments used for analysis and can easily be adapted for equipment that is available in a typical proteomics facility. Chapters detail many of the basic techniques used to detect and identify peptides, methods for the relative quantitation of peptides between samples using isotopic labels or label-free approaches, and biological species as well as sample types. Written in the highly successful format of the Methods in Molecular Biology series, each chapter includes an introduction to the topic, a list of the necessary materials and reagents, reproducible step-by-step laboratory protocols, and tips on troubleshooting common problems and avoiding pitfalls. Authoritative and practical, Peptidomics: Methods and Strategies provides useful guidance for studies in the rapidly growing field of peptidomics.
Download or read book The HLA FactsBook written by Steven G.E. Marsh and published by Elsevier. This book was released on 1999-12-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references
Download or read book Primary Immunodeficiency Diseases written by Hans D. Ochs and published by . This book was released on 2007 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Download or read book In Silico Immunology written by Darren D.R. Flower and published by Springer Science & Business Media. This book was released on 2007-04-16 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.
Download or read book Analysis of Peptide Binding to MHC Class I Molecules and the Function of Tapasin During the Binding Process written by Florian Sieker and published by . This book was released on 2008 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: MHC class I molecules play an important role in the adaptive immune response of mammalian immune systems. Class I molecules are loaded with antigenic peptides inside the endoplasmatic reticulum. After binding a high affinity peptide they are transported to the cell surface where their peptide cargo can be inspected by T-cells. In case the peptide cargo is recognized to be antigenic the T-cell will induce apoptosis of the infected cell. Despite their large structural similarity class I molecules differ in their dependence on tapasin. Tapasin is a chaperone protein and a part of the loading complex which is responsible for facilitating the binding of class I molecules and high affinity peptides. Several studies already revealed that even MHC molecules with almost identical sequences show great differences in their dependence on tapasin. Here I focus on two HLA-B alleles B*4402 and B*4405, respectively. The two alleles differ only at position 116 where the tapasin-dependent allele B*4402 carries an aspartate while the independent allele has a tyrosine. Although there are quite a number of hints for the function of tapasin the mode of action is still not known so far. Here, the difference between the two almost identical alleles was investigated to get an insight into the functioning of tapasin. Molecular dynamics simulations were performed to analyze the binding groove of MHC class I alleles which differ significantly in their tapasin-dependence with a high spatial and time resolution. Results suggested that one possible function of tapasin lies in stabilizing the alpha-2-1-helix which is next to the C-terminus of a bound peptide and near a proposed tapasin binding region at position 134.
Download or read book Immune Mediated Diseases written by Michael R Shurin and published by Springer Science & Business Media. This book was released on 2007-09-23 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.
Download or read book Peptide Therapeutics written by Ved Srivastava and published by Royal Society of Chemistry. This book was released on 2019-08-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
