Download or read book Analysis of Innate and Adaptive Immune Responses to Listeria Monocytogenes Infection written by and published by . This book was released on 2013 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunity to Listeria Monocytogenes written by E R Unanue and published by Academic Press. This book was released on 2012-01-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Listeria monocytogenes Pathogenesis and Host Response written by Howard Goldfine and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.

Download or read book Innate and Adaptive Immune Responses to Listeria Monocytogenes in the Presence and Absence of T Cells written by Molly M. Freeman and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative and Qualitative Analysis of the Adaptive Immune Response Against Listeria Monocytogenes written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recombinant Listeria Monocytogenes as an Anti tumor Vaccine and a Probe to Study Innate and Acquired Immunity written by Kevin Wendell Bruhn and published by . This book was released on 2004 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Inflammasome Activation Impairs Cell mediated Immunity to Listeria Monocytogenes written by Erin M. Theisen and published by . This book was released on 2017 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of the PI3K P110 in Innate and Adaptive Immune Responses to Listeria Monocytogenes written by Verity Quintina Pearce and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toll Like Receptors TLRs and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Download or read book Understanding Innate Immune Signaling During Listeria Monocytogenes Vaccination and Its Implications for Cancer Immunotherapy written by Zachary Taylor Morrow and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Listeria monocytogenes is a gram-positive facultative intracellular pathogen that stimulates a robust CD8+ T-cell response and has been utilized for decades to understand various aspects of innate and adaptive immunity. Due to its ability to stimulate CD8+ T-cells, L. monocytogenes has been developed as a safe anti-tumor vaccine platform. Efforts to understand how L. monocytogenes primes CD8+ T-cell responses led to the observation that L. monocytogenes that fail to access the host cytosol do not prime robust CD8+ T-cell responses. This led us to hypothesize that activation of a cytosol-specific innate immune pathway was necessary for the optimal T-cell response toward L. monocytogenes. Counterintuitively, I show that two cytosol-specific innate immune pathways activated by L. monocytogenes, the production of type I interferon, and inflammasome activation are actively detrimental to, or are dispensable for the T-cell response, respectively. Type I interferon impairs the formation of memory precursor effector cells, leading to deficits in protective immunity, and is likely acting on antigen presenting cells. I aided in identifying that macrophages and dendritic cells produce PGE2 during L. monocytogenes infection. The production of PGE2 is the first cytosol-specific innate immune pathway identified that is necessary for the optimal T-cell response toward L. monocytogenes. I show that PGE2 production is dependent on the calcium-dependent cytosolic phospholipase A2 (cPLA2) and that calcium fluxes necessary for PGE2 production are likely emanating from inositol-triphosphate-signaling dependent endoplasmic reticulum receptors. Finally, in an altogether different approach, I show that L. monocytogenes can be engineered to express and secrete mammalian cytokines as an in-situ vaccine platform. Taken together, my work demonstrates how innate immune signaling informs adaptive T-cell responses during L. monocytogenes vaccination, and that L. monocytogenes can be engineered to modulate innate immune pathways resulting in a better vaccine platform. This thesis begins to unravel how the first cytosol-specific innate immune pathway necessary for T-cell priming is triggered and highlights new avenues for the therapeutic application of L. monocytogenes to combat cancer.

Download or read book Foodborne Microbial Pathogens written by Arun K. Bhunia and published by Springer. This book was released on 2018-05-21 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book primarily covers the general description of foodborne pathogens and their mechanisms of pathogenesis, control and prevention, and detection strategies, with easy-to-comprehend illustrations. The book is an essential resource for food microbiology graduate or undergraduate students, microbiology professionals, and academicians involved in food microbiology, food safety, and food defense-related research or teaching. This new edition covers the significant progress that has been made since 2008 in understanding the pathogenic mechanism of some common foodborne pathogens, and the host-pathogen interaction. Foodborne and food-associated zoonotic pathogens, responsible for high rates of mortality and morbidity, are discussed in detail. Chapters on foodborne viruses, parasites, molds and mycotoxins, and fish and shellfish are expanded. Additionally, chapters on opportunistic and emerging foodborne pathogens including Nipah virus, Ebola virus, Aeromonas hydrophila, Brucella abortus, Clostridium difficile, Cronobacter sakazakii, and Plesiomonas shigelloides have been added. The second edition contains more line drawings, color photographs, and hand-drawn illustrations.

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Download or read book CRISPR Cas Systems written by Rodolphe Barrangou and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Download or read book Antiviral Substances including Interferon written by and published by . This book was released on 1977 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fish Oil Severely Impairs Immunity to Listeria Monocytogenes Without Affecting the Adaptive Immune Response written by Robert Dixon Irons and published by . This book was released on 2004 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: In mice infected with Listeria monocytogenes, a fish oil diet, rich in n-3 polyunsaturated fatty acids (n-3 PUFA), is associated with reduced survival and clearance of the bacteria from host tissues. The objective of this investigation was to determine to what extent dietary n-3 PUFA affect the development of adaptive immune responses against L. monocytogenes . Weanling female BALB/c mice were fed one of two experimental diets that differed only in that one was devoid of n-3 PUFA (i.e., lard) and the other was high in n-3 PUFA (i.e., menhaden fish oil). Mice were maintained on experimental diets for 28 d prior to immune challenge. We observed no impairment in the generation of immunological memory associated with n-3 PUFA feeding, even though bacterial clearance and survival were significantly reduced during the primary response. Further, the clonal expansion of Ag-specific CD8 + T cells was not altered by dietary n-3 PUFA. The absolute number of Listeria -specific CD4 + and CD8 + effector and memory/effector cells in the spleen were not affected, but the frequency of memory/effector cells was reduced by 50% in the n-3 PUFA-fed mice. Dietary n-3 PUFA did not significantly impair the ability of Ag-experienced splenocytes to adoptively transfer immunity to naive recipients on a low n-3 PUFA diet. Collectively, these results demonstrate that despite profoundly impairing host resistance during a primary infection with L. monocytogenes, the generation of adaptive immune responses does not appear to be compromised by n-3 PUFA.

Download or read book The New Microbiology written by Pascale Cossart and published by John Wiley & Sons. This book was released on 2020-07-10 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiology has undergone radical changes over the past few decades, ushering in an exciting new era in science. In The New Microbiology, Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology. This story has wide-ranging implications for human health and medicine, agriculture, environmental science, and our understanding of evolution. The revolution results from the powerful tools of molecular and cellular biology, genomics, and bioinformatics, which have yielded amazing discoveries, from entire genome sequences to video of bacteria invading host cells. This book is for both scientists and especially nonscientists who would like to learn more about the extraordinary world of bacteria. Dr. Cossart's overview of the field of microbiology research, from infectious disease history to the ongoing scientific revolution resulting from CRISPR technologies, is presented in four parts. New concepts in microbiology introduces the world of bacteria and some recent discoveries about how they live, such as the role of regulatory RNAs including riboswitches, the CRISPR defense system, and resistance to antibiotics. Sociomicrobiology: the social lives of bacteria helps us see the new paradigm by which scientists view bacteria as highly social creatures that communicate in many ways, for example in the assemblies that reside in our intestine or in the environment. The biology of infections reviews some of history's worst epidemics and describes current and emerging infectious diseases, the organisms that cause them, and how they produce an infection. Bacteria as tools introduces us to molecules derived from microbes that scientists have harnessed in the service of research and medicine, including the CRISPR/Cas9 genome-editing technology. The New Microbiology takes us on a journey through a remarkable revolution in science that is occurring here and now.