Download or read book Medicinal Chemistry written by Gareth Thomas and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: "It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
Download or read book An Introduction to Medicinal Chemistry written by Graham L. Patrick and published by Oxford University Press. This book was released on 2013-01-10 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
Download or read book An Outline of Medical Chemistry written by B. Howard Rand and published by . This book was released on 1855 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Practice of Medicinal Chemistry written by Camille Georges Wermuth and published by Elsevier. This book was released on 2003-06-11 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The only book available dealing with the practical aspects of medicinal chemistry Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Download or read book Medicinal Chemistry written by Thomas Nogrady and published by Oxford University Press. This book was released on 2005-08-11 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
Download or read book Chemistry An Introduction for Medical and Health Sciences written by Alan Jones and published by Wiley. This book was released on 2005-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry: An Introduction for Medical and Health Sciences provides students and practitioners with a clear, readable introduction to the chemical terms and concepts that are relevant to their study and practice. Assuming little prior knowledge of the subject the book describes and explains the chemistry underlying many of the most commonly prescribed drugs and medicines. It also includes information on chemical aspects of digestion and nutrition, oxidation, radioactivity and an overview of how chemicals fight disease. Excellent pedagogy including learning objectives, diagnostic tests and questions in each chapter and a comprehensive glossary Experienced author team with many years experience of teaching chemistry to non-chemists
Download or read book Basic Concepts in Medicinal Chemistry written by Marc Harrold and published by ASHP. This book was released on 2013-01-18 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Download or read book The Practice of Medicinal Chemistry written by Camille Georges Wermuth and published by Elsevier. This book was released on 2015-07-01 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com
Download or read book Essentials of Medicinal Chemistry written by Andrejus Korolkovas and published by Wiley-Interscience. This book was released on 1988-08-16 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.
Download or read book Fundamentals of Medicinal Chemistry written by Gareth Thomas and published by John Wiley & Sons. This book was released on 2004-04-20 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.
Download or read book Medicinal Chemistry written by Gareth Thomas and published by Wiley-Blackwell. This book was released on 2000-12-27 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides an introduction to the subject of medicinal chemistry, the study of the chemistry of therapeutically active compounds. Focusing on the chemical principles used for drug discovery and design, it also covers physiology and biology.
Download or read book An Outline of Medical Chemistry for the use of students written by Benjamin Howard RAND (M.D.) and published by . This book was released on 1855 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medicinal Chemistry for Practitioners written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2020-06-29 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Download or read book Medical Chemistry written by Charles Gilbert Wheeler and published by . This book was released on 1879 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Medicinal Chemistry III written by and published by Elsevier. This book was released on 2017-07-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Download or read book From Medical Chemistry to Biochemistry written by Robert E. Kohler and published by Cambridge University Press. This book was released on 1982-05-31 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This penetrating case study of institution building and entrepreneurship in science shows how a minor medical speciality evolved into a large and powerful academic discipline. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Science is shaped by its service roles in particular local contexts: This is the central theme. The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.
