Download or read book An Evaluation of EPA s Proposed Guidelines for Carcinogen Risk Assessment Using Chloroform and Dichloroacetate as Case Studies written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Toxicology and Cancer Risk Assessment written by Wai Nang Choy and published by CRC Press. This book was released on 2001-08-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Download or read book EPA Guidelines for Carcinogen Risk Assessment written by United States. Environmental Protection Agency and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dichloroacetic Acid written by and published by . This book was released on 1998 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2003 with total page 1532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Risk Assessment for Chemicals in Drinking Water written by Robert A. Howd and published by John Wiley & Sons. This book was released on 2007-11-09 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on state-of-the-art risk assessment methodologies for drinking water Risk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinetics, and modeling for both cancer and non-cancer endpoints Describes the practices of major organizations, including the U.S. EPA, Health Canada, World Health Organization, and California Office of Environmental Health Hazard Assessment Includes complete chapters on risk assessment for essential nutrients, arsenic, chloroform, and perchlorate Explains how to address susceptible sub-populations, including the elderly and infants and children, in risk assessments Covers the potential of using genomic and proteomic screens Addresses recent advances, emerging issues, and future challenges With contributions and perspectives from leading scientists, this is the definitive resource for health and environmental scientists, toxicologists, risk assessors and managers, regulators, consultants, and other professionals responsible for the safety of drinking water.
Download or read book Cancer Risk Assessment written by Ching-Hung Hsu and published by John Wiley & Sons. This book was released on 2010-12-08 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
Download or read book Toxicological Profile for Bromoform and Dibromochloromethane written by Syracuse Research Corporation and published by . This book was released on 2005 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Probabilistic Safety Assessment and Management written by Ali Mosleh and published by Springer Science & Business Media. This book was released on 1998-08-26 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes contain the papers presented at the 4th International Conference on Probabilistic Safety Assessment and Management (PSAM 4), held in New York City in September 98. The conference provided a forum for the presentation of innovative methods and applications of risk-based approaches to improve the design and operation of technological systems and processes from the economic and safety points of view. Papers reflect progress made on methods and applications in such areas as modeling and analysis of complex systems, human and organizational performance assessment, software reliability, data collection and analysis, expert judgement modeling and use, identification and assessment of various types of uncertainty, risk-informed regulatory and operational decision making, and public perception of risk. A diverse range of disciplines are represented including aerospace, nuclear, fossil fuels, chemical systems, marine technology, transportation, information technology, medical systems, environment, and defense.
Download or read book Health Risks to Fetuses Infants and Children written by and published by . This book was released on 1998 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicology of the Lung written by Donald E. Gardner and published by CRC Press. This book was released on 2000-01-20 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the third edition of Toxicology of the Lung brings together the latest accomplishments and advancements in concepts, approaches, and procedures now used to evaluate the risks associated with airborne contaminants. With chapters from leading authorities, including nine new chapters and a number of new topic areas, this edition describes how and why the lung and respiratory system respond as they do to toxicants and provides a clear understanding of human health risks associated with chemical exposure. This one-of-a-kind reference on inhalation toxicology will be invaluable to all professionals in academia, industry, clinics, research laboratories, and government agencies.
Download or read book Environmental Risk Assessment written by Ted Simon and published by CRC Press. This book was released on 2019-12-06 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. Indeed, the problems humankind faces in the 21st century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as health and safety regulations grow and become more complicated. Environmental Risk Assessment: A Toxicological Approach, 2nd Edition looks at various factors relating to exposure and toxicity, human health, and risk. In addition to the original chapters being updated and expanded upon, four new chapters discuss current software and platforms that have recently been developed and provide examples of risk characterizations and scenarios. Features: Introduces the science of risk assessment—past, present, and future Provides environmental sampling data for conducting practice risk assessments Considers how bias and conflict of interest affect science-based decisions in the 21st century Includes fully worked examples, case studies, discussion questions, and suggestions for additional reading Discusses new software and computational platforms that have developed since the first edition Aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments, the book delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk.
Download or read book Quantitative Modeling in Toxicology written by Kannan Krishnan and published by John Wiley & Sons. This book was released on 2010-04-01 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described. Topics covered include: the quantitative models of pharmacokinetics of individual chemicals and mixtures models for toxicant-target tissue interaction. models for cellular, organ, and organism responses. approaches, tools and challenges for model application and evaluation A website containing computer codes accompanies the book to help the reader reconstruct the models described and discussed in the various chapters. Quantitative Modeling in Toxicology serves as an essential reference source and tool box for risk assessors and researchers and students in toxicology, public health, pharmacology, and human toxicology interested in developing quantitative models for a better understanding of dose-response relationships.
Download or read book Reviews in Environmental Health 1999 written by and published by . This book was released on 1999 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Air Pollution and Health written by Robert L. Maynard and published by Elsevier. This book was released on 1999-04-21 with total page 1083 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern about the impact of air pollution has led governments and local authorities across the world to regulate, among other things, the burning of fossil fuels, industrial effluence, cigarette smoke, and aerosols. This legislation has often followed dramatic findings about the impact of pollution on human health. At the same time there have been significant developments in our ability to detect and quantify pollutants and a proliferation of urban and rural air pollution networks to monitor levels of atmospheric contamination. Air Pollution and Health is the first fully comprehensive and current account of air pollution science and it impact on human health. It ranges in scope from meteorology, atmospheric chemistry, and particle physics to the causes and scope of allergic reactions and respiratory, cardiovascular, and related disorders. The book has substantial international coverage and includes sections on cost implications, risk assessment, regulation, standards, and information networks. The multidisciplinary approach and the wide range of issues covered makes this an essential book for all concerned with monitoring and regulating air pollution as well as those concerned with its impact on human health. Only comprehensive text covering all the important air pollutants and relating these to human health and regulatory bodies Brings together a wide range of issues concerning air pollution in an easily accessible format Contributions from government agencies in the US and UK provide information on public policy and resource networks in the areas of health promotion and environmental protection
Download or read book Disinfection By Products in Drinking Water written by M Fielding and published by Elsevier. This book was released on 1999-01-01 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together contributors from water regulators, and water suppliers in Europe and North America to discuss the main issues associated with reaching a cost-effective balance between microbial and chemical risks. Overviews of research are presented alongside illuminating case studies of the practical approaches taken by water companies and regulators on both sides of the Atlantic.
Download or read book Chloroform written by Peter Watts and published by World Health Organization. This book was released on 2004-10-08 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chloroform is a clear, colourless, volatile liquid which is used in the production of refrigerants and as a fluoropolymer feedstock. It may be released into the environment from chlorodifluoromethane plants and from pulp and paper mills using chlorine-based chemicals for bleaching and disinfection purposes. Chloroform is also the principal by-product of water disinfectant processes. It is estimated that the vast majority of chloroform emissions into the environment are natural in origin. This publication, part of a series from the International Programme on Chemical Safety, evaluates the risk to human health and the environment posed by exposures to chloroform.
