Download or read book Alzheimer s Disease A Century of Scientific and Clinical Research written by G. Perry and published by IOS Press. This book was released on 2006-06-26 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.
Download or read book Alzheimer s Disease Advances for a New Century written by IOS Press and published by IOS Press. This book was released on 2013-02-15 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a companion to the highly successful book published in association with the Journal of Alzheimer’s Disease (JAD) on the centennial of Alzheimer’s discovery: “Alzheimer’s Disease: A Century of Scientific and Clinical Research”. Instead of looking back, this collection, “Alzheimer’s Disease: Advances for a New Century”, will look forward. Using scientometric analysis the most promising developments since the Alzheimer Centennial in 2006 have been substantiated. While prior trends and advances in genetics, amyloid-?, tau, neuropathology, and oxidative stress continue as active areas, emergent areas impacting the transition from normal cognition to Alzheimer’s disease such as diagnostic imaging, biomarkers, metabolism, and lifestyle (areas conceived only a few years ago) now dominate the debate. Invited contributors have summarized their landmark publications identified by our analysis and have put them into perspective, explaining the impetus behind the work, the contribution of the results to the field, and who played a role in the work.
Download or read book Global Clinical Trials for Alzheimer s Disease written by Menghis Bairu and published by Academic Press. This book was released on 2013-08-28 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease. Written by leading experts with hands-on experience in designing and running global Alzheimer’s disease and other neurodegenerative diseases clinical trials A step-by-step guide that provides critical information on the design, conduct and standardization necessary to effectively execute clinical trials and accelerate drug development in this area Includes practical examples, ethical considerations, lessons learned and other valuable tools to aid the planning and implementation of Alzheimer’s disease global clinical trials in emerging markets and developing countries
Download or read book Global Clinical Trials for Alzheimer s Disease written by Peter Schüler and published by Elsevier Inc. Chapters. This book was released on 2013-08-28 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: To date (2013), we have witnessed over 100 years of research on Alzheimer’s disease (AD). In the past century, this gave new and deep insights into its pathophysiology. However, no new treatment with an innovative mode of action has found its way to the patients since the first targeted therapies with cholinergic drugs like Tacrin. So far A-beta and related targets have shown negative results in pivotal Phase III studies, after showing promising trends in Phase II. Thus the question arises as to whether A-beta is the wrong target for disease-modifying treatments, or whether other substantial changes to clinical development plans need to be made, e.g. including patients at risk of developing AD instead of those already experiencing symptoms. Alternative targets and study design options like enrichment strategies, however, do not evolve as an easy alternative solution.
Download or read book How Not to Study a Disease written by Karl Herrup and published by MIT Press. This book was released on 2021-10-05 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected "neighborhoods." He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.
Download or read book Alzheimer s Disease Decoded The History Present And Future Of Alzheimer s Disease And Dementia Second Edition written by Ronald Sahyouni and published by World Scientific. This book was released on 2021-12-23 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a 'global' perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world.Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective.This book with appeal to a wide audience, regardless of their scientific or educational background.
Download or read book The Problem of Alzheimer s written by Jason Karlawish and published by St. Martin's Press. This book was released on 2021-02-23 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.
Download or read book Alzheimer s Disease Decoded The History Present and Future of Alzheimer s Disease and Dementia 2nd Edition written by Ronald Sahyouni and published by World Scientific Publishing Company. This book was released on 2021-12-23 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world. Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research. Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease. Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective. This book with appeal to a wide audience, regardless of their scientific or educational background.
Download or read book Self Senility and Alzheimer s Disease in Modern America written by Jesse F. Ballenger and published by JHU Press. This book was released on 2006-03-31 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ballenger's work contributes to our understanding of the emergence and significance of dementia as a major health issue.
Download or read book Global Clinical Trials for Alzheimer s Disease written by Debbie N. Cote and published by Elsevier Inc. Chapters. This book was released on 2013-08-28 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: About 2% of the United States population gets involved with clinical research trials each year; among those people who suffer from severe, chronic illnesses (including Alzheimer’s disease), only 6% participate. As a result, an increasing number of clinical trials are delayed because too few people ever know they had an opportunity to get involved. Recruitment strategies consist of effective campaigns that reach the intended population of potential patients. A strategy using several tactics will most likely achieve the best outcome. The art of patient recruitment is to cast a wide net, combining a patient-centric enrollment focus, involving the use of social media and conventional media, coupled with customer-“friendly” protocols. Investigative sites providing a high level of customer satisfaction may result in accelerating enrolment, improving retention and thereby reducing the overall study cost.
Download or read book Pharmacological Treatment of Alzheimer s Disease written by Gustavo Alves Andrade dos Santos and published by Springer Nature. This book was released on 2022-03-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease is the most prevalent form of dementia. Although it was discovered about a century ago, the first drugs applied in treatment were only introduced in therapy in the last 30 years. This book focuses on the clinical pharmacology of drugs that aim to delay the progression of Alzheimer’s disease, such as anticholinesterases and glutamate receptor antagonists, as well as treatment for the behavioral changes caused by the progression of the disease: antidepressants, antipsychotics, anxiolytics, and mood stabilizers. In addition, it describes important information about the pathophysiology and diagnostic methods of Alzheimer’s disease, emergency situations conditioned by the dementia process, and presents new perspectives for the treatment of Alzheimer’s disease. The ten chapters cover topics such as mechanism of action, dosage regimen, adverse reactions, drug interactions, toxicity profiles, among other information of clinical relevance. The work comprises evidence-based studies, providing a valuable resource for analyzing, prescribing and monitoring patients being treated for Alzheimer’s disease. Written by experts with solid professional experience, this book will appeal to pharmacologists, geriatricians, neurologists, psychiatrists, biomedical clinicians, and other healthcare professionals.
Download or read book Global Clinical Trials for Alzheimer s Disease written by Menghis Bairu and published by Elsevier Inc. Chapters. This book was released on 2013-08-28 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 35 million people worldwide are living with dementia, the vast majority Alzheimer’s disease (AD)-related. By 2050, Alzheimer’s disease cases will triple to 115 million—one new case every four seconds—placing untold stress on overburdened social service and healthcare delivery systems, a potentially catastrophic global epidemic. Sixty percent of Alzheimer’s disease victims now live in lesser developed countries. In 2050, these countries will account for 71% of the total Alzheimer’s disease caseload. In 2010, the annual cost of AD was estimated at US$604 billion and rising, i.e., roughly 1% of the world’s gross domestic product. Many Alzheimer’s disease victims are stigmatized, resulting in isolation, abandonment, and withdrawal. Diagnosis and treatment are often non-existent. Only 9 of the 193 World Health Organization member states have implemented national dementia plans, all in the developed world. However, there is some promising news. National models for mitigating the epidemic exist. Research and recommendations are available to assist developing countries in blunting the worst ravages of the epidemic.
Download or read book Alzheimer 100 Years and Beyond written by Mathias Jucker and published by Springer. This book was released on 2009-09-02 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Download or read book Advances in Alzheimer Research written by Debomoy K. Lahiri and published by . This book was released on 2013-11-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Alzheimer's disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alz"
Download or read book Meeting the Challenges of Alzheimer s Disease written by United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging and published by . This book was released on 1997 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alzheimer s Disease Pathological and Clinical Findings written by Blas Gil-Extremera and published by Bentham Science Publishers. This book was released on 2019-04-03 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease. This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer’s disease, pathological features of the disease in the brain, Alzheimer’s disease diagnosis and therapy. Information provided in the book is focused on research in developed countries. The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.
