Download or read book Alternative Splicing and Adhesion Properties of a Mouse Carcinoembryonic Antigen Gene Family Member written by Kimberly McCuaig and published by . This book was released on 1992 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Carcinoembryonic antigen (CEA) is a tumor marker used clinically to assess post-operative recurrences of breast, lung and colon cancers. The CEA gene family, which is part of the immunoglobulin superfamily, is composed of several proteins crossreactive with anti-CEA antibodies. Carcinoembryonic antigen appears to function in the development of the gastro-intestinal tract as well in tumor formation; it is capable of mediating cell-cell adhesion in vitro which is consistent with its putative role of maintaining tissue architecture in vivo. CEA gene family members have also been identified in various tissues of the mouse. Two of the mouse proteins, mmCGMla and mmCGMlb, have been characterized. By sequence homology, mmCGMla and mmCGMlb are the mouse homologues of human biliary glycoprotein and of rat hepatocyte ecto-ATPase. Both of the mouse CEA related proteins function as adhesion molecules when expressed on the cell surface of transfectant cells; however, mmCGMla, unlike mmCGMlb, mediates cellular aggregation irrespective of calcium concentration or temperature. Sequence comparison of mmCGMla, mmCGMlb, and other cDNAs isolated by polymerase chain reaction techniques, demonstrates that there are at least eight possible transcripts encoding CEA-related proteins and that these transcripts are all produced by alternative splicing of one precursor messenger RNA." --

Download or read book Cell Adhesion and Communication Mediated by the CEA Family written by Clifford P Stanners and published by CRC Press. This book was released on 2003-09-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.

Download or read book Structure based Study of Viral Replication written by R. Holland Cheng and published by World Scientific. This book was released on 2008 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Human rhinovirus cell entry and uncoating / Renate Fuchs and Dieter Blaas -- ch. 2. Role of lipid microdomains in influenza virus multiplication / Makoto Takeda -- ch. 3. Functions of integrin alpha2beta1, a collagen receptor, in the internalization of echovirus 1 / Varpu Marjomäki [und weitere] -- ch. 4. Entry mechanism of murine and SARS coronaviruses - similarity and dissimilarity / Fumihiro Taguchi -- ch. 5. Hepatitis viruses, signaling events, and modulation of the innate host response / Syed Mohammad Moin, Anindita Kar-Roy and Shahid Jameel -- ch. 6. Virus-cell interaction of HCV / Hideki Tani [und weitere] -- ch. 7. RNA replication of hepatitis C virus / Hideki Aizaki and Tetsuro Suzuki -- ch. 8. Structure and dynamics in viral RNA packaging / Thorsten Dieckmann and Marta Zumwalt -- ch. 9. Rational design of viral protein structures with predetermined immunological properties / James Lara and Yury Khudyakov -- ch. 10. Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute / Anjan Purkayastha [und weitere] -- ch. 11. Virus architecture probed by atomic force microscopy / A.J. Malkin [und weitere] -- ch. 12. Filovirus assembly and budding / Takeshi Noda and Yoshihiro Kawaoka -- ch. 13. Challenges in designing HIV Env immunogens for developing a vaccine / Indresh K. Srivastava and R. Holland Cheng -- ch. 14. Insights into the Caliciviridae family / Grant Hansman -- ch. 15. Mathematical approaches for stoichiometric quantification in studies of viral assembly and DNA packaging / Peixuan Guo, Jeremy Hall and Tae Jin Lee -- ch. 16. Virus-like particles of fish nodavirus / Chan-Shing Lin -- ch. 17. The assembly of the double-layered capsids of phytoreoviruses / Toshihiro Omura [und weitere] -- ch. 18. Structure and assembly of human herpesviruses: new insights from cryo-electron microscopy and tomography / Z. Hong Zhou and Pierrette Lo -- ch. 19. Human papillomavirus type 16 capsid proteins: immunogenicity and possible use as prophylactic vaccine antigens / Tadahito Kanda, Kei Kawana and Hiroyuki Yoshikawa -- ch. 20. Chimeric recombinant Hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration / Yasuhiro Yasutomi -- ch. 21. Nucleocapsid protein of hantaviruses (Bunyaviridae): structure and functions / Alexander Plyusnin [und weitere] -- ch. 22. Astrovirus replication: an overview / Susana Guix, Albert Bosch and Rosa M. Pintó -- ch. 23. DNA vaccines against viruses / Britta Wahren and Margaret Liu -- ch. 24. Life cycles of polyomaviridae - DNA tumor virus / Masaaki Kawano, Hiroshi Handa and R. Holland Cheng

Download or read book Masters Abstracts International written by and published by . This book was released on 1994 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1987 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Research written by and published by . This book was released on 1997 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2000 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology Biochemistry and Biophysics written by and published by . This book was released on 2000 with total page 1588 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Guidebook to the Extracellular Matrix Anchor and Adhesion Proteins written by Thomas Kreis and published by Sambrook and Tooze Publications. This book was released on 1999 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.

Download or read book Journal of Cell Science written by and published by . This book was released on 1994 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics Abstracts written by and published by . This book was released on 1996 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of Membrane Transport Disorders written by Thomas E. Andreoli and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the six of us gathered to start planning for what was to be the Third Edition of Physiology of Membrane Disorders, it was clear that since 1986, when the Second Edition appeared, the field had experienced the dawning of a new era dominated by a change in focus from phenomenology to underlying mechanisms propelled by the power of molecular biology. In 1985, detailed molecular information was available for only three membrane transporters: the lac permease, bacterial rhodopsin, and the acetylcholine receptor. During the decade that has since elapsed, almost all of the major ion channels and transport proteins have been cloned, sequenced, mutagenized, and expressed in homologous as well as heterologous cells. Few, if any, of the transporters that were identified during the previous era have escaped the probings of the new molecular technologies and, in many instances, considerable insight has been gained into their mechanisms of function in health and disease. Indeed, in some instances novel, unexpected transporters have emerged that have yet to have their functions identified. The decision to adopt the new title Molecular Biology of Membrane Transport Disorders was a natural outgrowth of these considerations.

Download or read book The Journal of Cell Biology written by and published by . This book was released on 1991 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .

Download or read book Gnotobiotics written by Trenton R Schoeb and published by Academic Press. This book was released on 2017-08-11 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility

Download or read book Cell Adhesion Molecules 1 written by Thomas Brümmendorf and published by . This book was released on 1994 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Leong s Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.

Download or read book A Guide to Human Gene Therapy written by Roland W. Herzog and published by World Scientific. This book was released on 2010 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clinical studies in gene therapy / Caroline Le Guiner [und weitere] -- 11. Gene therapy for central nervous system disorders / Deborah Young and Patricia A. Lawlor -- 12. Gene therapy of hemoglobinopathies / Angela E. Rivers and Arun Srivastava -- 13. Gene therapy for primary immunodeficiencies / Aisha Sauer, Barbara Cassani and Alessandro Aiuti -- 14. Gene therapy for hemophilia / David Markusic, Babak Moghimi and Roland Herzog -- 15. Gene therapy for obesity and diabetes / Sergei Zolotukhin and Clive H. Wasserfall -- 16. Gene therapy for Duchenne muscular dystrophy / Takashi Okada and Shin'ichi Takeda -- 17. Cancer gene therapy / Kirsten A.K. Weigel-Van Aken -- 18. Gene therapy for autoimmune disorders / Daniel F. Gaddy, Melanie A. Ruffner and Paul D. Robbins -- 19. Gene therapy for inherited metabolic storage diseases / Cathryn Mah -- 20. Retinal diseases / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- 21. A brief guide to gene therapy treatments for pulmonary diseases / Ashley T. Martino, Christian Mueller and Terence R. Flotte -- 22. Cardiovascular disease / Darin J. Falk, Cathryn S. Mah and Barry J. Byrne