Download or read book Alpha fetoprotein and Its Receptor in Fixing the Cancer Brakes written by Vladimir N. Pak and published by Cambridge Scholars Publishing. This book was released on 2021-03-25 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the crucial role of a unique alpha-fetoprotein (AFP) in the treatment of cancer. AFP can deliver toxins through specific receptors re-expressed in the majority of cancer cells, serving as a targeted chemotherapy. More importantly, AFP+toxin harnesses the patient’s immune system in order to attack cancer. Depleting the regulatory top monocyte-derived suppressor cells (MDSCs) activates both the innate and adaptive immune responses. The thoroughly chosen toxins switch on apoptosis in MDSCs, restore the broken one in cancer cells, and destroy them naturally without any harmful by-products. Injections with AFP+toxin preparations have shown promising results in animals and the treatment of cancer patients. In addition to this breakthrough, the book also discusses the peroral administration of porcine AFP non-covalent complexes with selected toxins in patients with metastases. It will appeal to science researchers, clinicians, and medical students, as well as the more general reader.

Download or read book Alpha Fetoprotein written by Nisha Lakhi and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alpha-fetoprotein (AFP) has many applications across various disciplines. This oncofetal protein is routinely used by clinicians for antenatal testing as well for the screening and treatment monitoring of certain malignances. Innovative research using AFP has also been very promising. Recent developments include the use of AFP or its recombinant fragments for drug delivery to cancer cells, as well as for the engineering of cancer vaccines and T cell immunotherapies. The anti-estrogenic potential of AFP has also been utilised to develop drugs directed against estrogen receptor positive malignancies. This book is divided into five sections. In Section One, the history of AFP is recollected, and the role of AFP in normal and pathological conditions is explored. Section Two and Three focus on the utility of AFP during pregnancy. In Section Two, the use of routine maternal serum AFP screening for detection of chromosomal aneuploidies and neural tube defects in normal pregnancies and pregnancies with pre-existing disease is discussed; the potential use of AFP for the detection of preeclampsia is also reviewed. Section Three explores the pathogenesis and data linking unexplained elevations of AFP to adverse obstetrical outcomes. Section Four presents chapters that discuss AFP ligand binding, receptor targeting, and drug delivery strategies. Finally, Section Five serves to explain the regulatory roles of AFP, its use in immunotherapy, and in the development of cancer vaccines. The aim of this book is to bring together some of the great research and clinical insights that currently surround AFP. The target audiences for this book are basic science researchers as well as clinicians.

Download or read book Human Alpha fetoprotein written by Bent Nørgaard-Pedersen and published by . This book was released on 1976 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Maternal Serum Alpha fetoprotein written by and published by . This book was released on 1980 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha fetoprotein and Congenital Disorders written by Gerald J. Mizejewski and published by . This book was released on 1985 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha fetoprotein and Hepatoma written by Hidematsu Hirai and published by . This book was released on 1973 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Prevention of Neural Tube Defects written by Barbara F. Crandall and published by . This book was released on 1978 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha fetoprotein Screening in Obstetric Practice written by Agneta Schnittger and published by . This book was released on 1984 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cellular fluctuations alpha fetoprotein expression and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis written by Wolf-Dieter Kuhlmann and published by Cuvillier Verlag. This book was released on 2023-05-25 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocytes and bile ductular cells possess stem-like potential in restoring liver tissue. This was derived from rat and mouse injury models such as (a) partial hepatectomy by surgery; (b) acute carbon tetrachloride intoxication; © injuries by D-galactosamine (GalN) or by N-nitrosomorpholine (NNM); (d) experimental hepatocarcinogenesis with NNM using different doses. Liver parenchyma was restored by adult hepatocytes after partial hepatectomy as well as after carbon tetrachloride intoxication. Concurrently, hepatocytes resumed synthesis of alpha-1-fetoprotein (AFP) which depended to a high degree on the animal species and strains used in that studies. In contrast to this way of regeneration, liver repair after heavy injuries by agents such as GalN and NNM was initiated by oval cell proliferation deriving from ductular epithelial cells of the canaliculi of HERING (canals of Hering, intrahepatic bile ductules) as sources of endogenous progenitors. Progenitor populations reach levels of differentiation with fetal gene reactivation and significant AFP expression. Proliferating oval cells operated as transit and amplification compartment during liver regeneration. Oval cell proliferation and concurrent AFP synthesis occurred also in the early stages of hepatocarcinogenesis when the carcinogen NNM was applied in toxic doses. The histologic features compared to those seen in GalN intoxication. NNM carcinogenicity was of concern for both oval cells and adult hepatocytes with risks of transformation and malignant development. At the cancer stage, carcinomas either synthesizing AFP or not can be found side by side in the same liver. AFP expression by cancer cells seems to be a special attribute to differentiation stages in carcinogenesis. Clonality, maturation arrest and retro-differentiation feature cells with high autonomy.

Download or read book Alpha fetoprotein in Clinical Medicine written by Jörg Schneider and published by . This book was released on 1979 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha Fetoprotein written by Hannu Jalanko and published by . This book was released on 1979 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biological Activities of Alpha1 Fetoprotein written by Gerald J. Mizejewski and published by Springer. This book was released on 1987-05-31 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biological Activities of Alpha fetoprotein written by and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Alpha fetoprotein written by Yuri S. Tatarinov and published by . This book was released on 1994 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha fetoprotein Laboratory Procedures and Clinical Applications written by Anita M. Kirkpatrick and published by . This book was released on 1981 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Obstetric Imaging Fetal Diagnosis and Care E Book written by Joshua Copel and published by Elsevier Health Sciences. This book was released on 2017-07-18 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richly illustrated and comprehensive in scope, Obstetric Imaging, 2nd Edition, provides up-to-date, authoritative guidelines for more than 200 obstetric conditions and procedures, keeping you at the forefront of this fast-changing field. This highly regarded reference covers the extensive and ongoing advances in maternal and fetal imaging in a concise, newly streamlined format for quicker access to common and uncommon findings. Detailed, expert guidance, accompanied by superb, high-quality images, helps you make the most of new technologies and advances in obstetric imaging. Features more than 1,350 high-quality images, including 400 in color. Helps you select the best imaging approaches and effectively interpret your findings with a highly templated, bulleted, at-a-glance organization. Reflects all the latest developments in the field, including genetics, open fetal surgery, fetal echocardiography, Zika virus, and 3D imaging, so you can provide the safest and most responsive care to both mother and fetus. Includes new chapters on Limbs and Bones Overview; Open Fetal Surgery; Biophysical Profile; Ultrasound Physics; Elastography; Doppler; MRI; Echogenic Bowel; Pregnancy of Unknown Location (PUL), Failed Pregnancy and Ectopic Pregnancy, Cesarean Scar Pregnancy; Cytomegalovirus (CMG), Rubella, Toxoplasmosis, Herpes, Varicella; and Congenital Syphilis; plus a new chapter on Zika Virus written by imaging experts from the "hot zone." Keeps you up to date with the latest developments in multimodality imaging and optimizing diagnostic accuracy from ultrasound, 3D ultrasound, Doppler, MRI, elastography, image-guided interventions, and much more.

Download or read book Alpha Fetoprotein written by Helena Pihko and published by . This book was released on 1975 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: