Download or read book Alkaline Phosphatase written by Robert B. McComb and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: There can be no doubt that alkaline phosphatase is one of the most extensively in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the ease and sensitivity with which its activity can be measured. Unfortunately, these wide-ranging but often superficial experimental studies have been followed up by intensive and systematic investigations in only a few limited areas of the biochemistry and chemical pathology of alkaline phosphatase. The result has been the accumulation of a scientific literature of intimidating proportions, and the inevitable rediscovery of already known facts about the enzyme. Scientists are taught early in their careers that, in the words of Sir John Herschel, "Hasty generalization is the bane of science. " Nevertheless, moments arrive in all spheres of scientific activity when generalization becomes essential, to codify and to select from the mass of data already accumulated, and to provide starting points for new developments and new lines of investigation. This is especially true in a field such as alkaline phosphatase research, in which very real dangers exist that the seeds of fundamental understanding will be lost amidst an unexamined harvest of empirical observations. The history of the study of alkaline phosphatase provides several instances when valuable generalizations have emerged. Occasionally, the conclusions drawn on the basis of available evidence were wrong; more frequently, they have stood the test of further experimentation, and always, they have provided new insights into the nature and proper ties of this enzyme.
Download or read book Neuronal Tissue Nonspecific Alkaline Phosphatase TNAP written by Caroline Fonta and published by Springer. This book was released on 2015-07-28 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.
Download or read book Mammalian Alkaline Phosphatases written by José Luis Millan and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Download or read book Phosphatase Modulators written by José Luis Millán and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Download or read book Equine Reproductive Procedures written by John Dascanio and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Equine Reproductive Procedures is a user-friendly guide to reproductive management, diagnostic techniques, and therapeutic techniques on stallions, mares, and foals. Offering detailed descriptions of 161 procedures ranging from common to highly specialized, the book gives step-by-step instructions with interpretative information, as well as useful equipment lists and references for further reading. Presented in a highly portable spiral-bound format, Equine Reproductive Procedures is a practical resource for daily use in equine practice. Divided into sections on the non-pregnant mare, the pregnant mare, the postpartum mare, the stallion, and the newborn foal, the book is well-illustrated throughout with clinical photographs demonstrating procedures. Equine Reproductive Procedures provides practical guidance for performing basic and advanced techniques associated with the medical management of horses.
Download or read book Therapeutic Enzymes Function and Clinical Implications written by Nikolaos Labrou and published by Springer Nature. This book was released on 2019-09-03 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology
Download or read book Handbook of Genetics written by Robert C. King and published by Springer. This book was released on 1974-11-01 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this and future volumes of the Handbook of Genetics is to bring together a collection of relatively short, authoritative essays or annotated compilations of data on topics of significance to geneticists. Many of the essays will deal with various aspects of the biology of certain species selected because they are favorite subjects for genetic investigation in nature or the laboratory. Often there will be an encyclopedic amount of information available on such a species, with new papers appearing daily. Most of these will be written for specialists in a jargon that is be wildering to a novice, and sometimes even to a veteran geneticist working with evolutionarily distant organisms. For such readers what is needed is a written introduction to the morphology, life cycle, reproductive be havior, and culture methods for the species in question. What are its par ticular advantages (and disadvantages) for genetic study, and what have we learned from it? Where are the classic papers, the key bibliographies, and how does one get stocks of wild type or mutant strains? The chapters devoted to different species will contain information of this sort. Only a few hundreds of the millions of species available to biologists have been subjected to detailed genetic study. However, those that have make up a very heterogeneous sample of the living world.
Download or read book Biomarkers in Bone Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Download or read book Alkaline Phosphatase written by and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Displacement Mechanisms in Enzymatic Reactions written by Daniel E. Koshland (Jr.) and published by . This book was released on 1954 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Estimation of Serum Alkaline Phosphatase written by Smita Kaushik and published by Elsevier Health Sciences. This book was released on 2019-08-31 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimation of Serum Alkaline Phosphatase
Download or read book Clinical Enzymology written by John C. Griffiths and published by . This book was released on 1979 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small Animal Medical Differential Diagnosis written by Mark S. Thompson and published by Elsevier Health Sciences. This book was released on 2014 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small Animal Medical Differential Diagnosis, 2nd Edition is a practical, concise guide to the differential diagnosis, etiology, laboratory abnormalities, and classification of clinical signs and medical disorders in dogs and cats. By covering nearly every possible sign and clinical disorder relevant to small animal medical practice, this pocket-sized, rapid reference helps you make more reliable on-the-scene decisions. More than 400 lists bring the most important medical diagnostic information from multiple resources into a single rapid reference. An organized presentation of differential diagnoses by sign and symptom, disorder, and body system, facilitates quick and flexible access to information at many stages of the diagnostic work-up. Alphabetical listing of all relevant laboratory tests makes information easy to find for students and experienced practitioners alike. Easily identify the likeliest diagnosis by reviewing the possibilities listed in order of incidence. Pocket-sized for portability, practicality, and quick reference. NEW! Coverage of new disorders and syndromes expands the span of differential diagnoses to help you effectively evaluate more signs and symptoms. NEW! Addition of new and more widely used diagnostic and laboratory tests keeps you up-to-date as lab tests become more specialized and sophisticated.
Download or read book Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East AFE 2021 written by Aleksei Muratov and published by Springer Nature. This book was released on 2021-11-23 with total page 1194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uses digital technologies for the sustainable development and productivity of the agricultural sector. The book presents technical developments in the IoT sector, sensors and smart agriculture machines, as well as solutions to digitize the farmer's life by delivering holistic management platforms and monitoring systems. The papers presented in the book are proceedings of the conference “Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East (AFE-2021)”, which took place in Ussuriysk, Russia. Innovative developments in the field of precision livestock farming, application of fertilizers of a new generation and production of eco-friendly products are presented here. This book is an indispensable tool for farming in any climatic conditions and any climatic zones, since it shares the experience of sustainable farming in the Far East region, which is very valuable in conditions of a changing climate and stricter requirements of the market. The research results presented in the book will help in making the right decisions about the allocation of resources in agricultural systems. The book will allow increasing awareness about the benefits of precision livestock farming, optimizing agricultural production, helping the farmers maximize their yield and minimize losses with efficient use of resources and decreasing skilled labor in agriculture.
Download or read book Phosphoric Acid Industry written by Michael Schorr and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoric acid is an important industrial acid that is utilized for manufacturing phosphatic fertilizers and industrial products, for pickling and posterior treatment of steel surfaces to prevent corrosion, for ensuring appropriate paint adhesion, and for the food and beverages industry, e.g., cola-type drinks to impart taste and slight acidity and to avoid iron sedimentation. This industry is spread out in countries of four continents - Asia, Africa, America, and Europe - which operate mines and production plants and produce fertilizers. Phosacid is one of the most widely known acids. The global phosacid market and its many phosphate derivatives are expanding worldwide; this trend is expected to continue in the next years, thus producing innovative products.
