Download or read book Aldehyde Adducts in Alcoholism written by Michael Aldis Collins and published by . This book was released on 1985 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aldehyde Adducts in Alcoholism written by Michael A. Collins and published by John Wiley & Sons. This book was released on 1985-08 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cytochrome P450 2E1 Its Role in Disease and Drug Metabolism written by Aparajita Dey and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Download or read book Alcoholism A Molecular Perspective written by T. Norman Palmer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected proceedings from the NATO Advanced Study Institute (AS I) "The Molecular Pathology of Alcoholism" held at the Hotel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that the total cost to the economy of alcohol abuse is $117 billion. Treatment of alcohol dependence and other alcohol-related disorders accounts for almost 15% of the total health bill of the United States. Despite the scale of the medical problem, biomedical research on alcoholism remains something of a 'Cinderella science'. Research funding from government and other bodies is relatively poor and the number of medical scientists working in the field remains small. The Organizing Committee for this NATO ASI, comprising Charles Lieber (New York), Timothy Peters (London), Mario Dianzani (Torino), Emanuele Albano (Torino) and Norman Palmer (perth, Director), were therefore particularly grateful to the NATO Scientific Affairs Division for their active support of this AS I, the first dealing with a topic related to alcohol abuse. We moreover hope that this support will continue. The theme of the ASI was an in depth discussion of the molecular events initiated by alcohol abuse that culminate in onset of alcohol-related disease.

Download or read book Acetaldehyde Related Pathology written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-04-30 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.

Download or read book Hemoglobin acetaldehyde Adducts written by Pekka Sillanaukee and published by . This book was released on 1992 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ronald Thurman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this book represent the proceedings of the Third International Symposium, which was held at the Addiction Research Foundation in Toronto in July, 1979. The purpose of this meeting was to bring together experts in the field from a wide variety of backgrounds in an attempt to gain some clarity and insight into the problems of alcohol and aldehyde metabolism. One might ask, "Why have such a meeting and a collection of research papers?" The answer is clear. The societal problem of alcoholism is, unlike many other health problems, growing instead of abating. Treatment efforts are largely ineffective (e.g., Griffith Edwards' classic work)', and fundamental research has yet to identify rational therapy based on sound mechanisms for this disease which effects 5% of the population severely and a much greater percentage to a lesser degree or indirectly. I have become impressed with the possibility that this lack of progress may be-in large part-due to a fundamental oversight on the part of investigators in the field of alcohol research. Simply, this possible problem could be stated as follows: an alcoholic is defined the same way as all other alcoholics. Attempts to identify possible subpopulations of alcoholics with defined and treatable diseases have been minimal. One could argue, however, that little evidence, with the exception of the gross psychiatric definitions (e.g., Jellinek) exists that there are different types of alcoholics. This argument is countered, first, by the dismal lack of progress made in this field by classifying an alcoholic equal to other alcoholics, and second, by analogy with cancer research. Now we know that "cancer" is only a generic term which defines a broad group of diseases, some caused by specific environmental chemicals, others by viruses, etc. Progress was only possible after suitable animal models were developed. More importantly, however, is the fact that once specific forms of the disease (i.e., once the diseases themselves were separated from the generic term) were identified, it was a relatively easy task to develop tests for early identification of some forms of the disease (e.g., the pap smear, etc.). This analogy can be extended to alcoholism's. First, let us assume that we have failed to develop tests for early identification of alcoholisms because the population is not carefully defined into subgroups. If we assume that subpopulations of alcoholics exist, we can again turn to the cancer literature for examples of how to proceed. Much progress in this field rests. On the careful development of strains of animals which differ in their susceptibility to certain carcinogens. By analogy, distinct forms of alcoholisms could be identified by the use of genetics (e.g., Goodwin). First, distinct phenotypes need to be developed for certain characteristics suspected to be important in alcoholism. Second, a test specific for early identification of this specific phenotype can then be developed. Third, longitudinal studies must be performed in humans to see if the animal work can be applied to man. Implicit in this rationale is the thought that progress is not possible by studying alcoholics 20 years after primary changes had occurred, nor even by studying pre-alcoholics until specific sub forms of the disease are identified. Thus, the need for fundamental research into the mechanisms responsible for alcoholism is required. Unfortunately, alcohol research appears to suffer some of the stigma of the alcoholic

Download or read book Alcohol in Health and Disease written by Dharam Agarwal and published by CRC Press. This book was released on 2001-06-01 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, based on presentations from the symposium on the health effects of alcohol held in Titisee, Germany, examines the physical and psychological consequences of alcohol use and abuse, and considers environmental and ethnic factors that lead to addiction and dependence. Discusses epidemiological studies that show the influence of light to moderate intake of alcoholic beverages on coronary heart disease. Featuring contributions from nearly 60 internationally recognized and respected authors, and over 2900 references for further investigation of the subject, Alcohol in Health and Disease analyzes biochemical, pharmacogenetic, and pathologic disturbances that follow acute and chronic ingestion of alcohol; describes complications that arise from social, biological, and environmental factors; examines alcohol metabolic genes and their role in alcohol sensitivity, drinking habits, and dependence; spotlights hepatic and nutritional disorders associated with alcoholism; considers the relationship of alcohol to cancer; debates the French paradox and more. Covering a multitude of disciplines, including molecular biochemistry, genetics, epidemiology, pathophysiology, neurobiology, and cardiology, Alcohol in Health and Disease is a critical reference for addiction psychiatrists, neuropsychopharmacologists, psychologists, geneticists, toxicologists, biochemists, environmental and public health scientists, health policy makers, social workers, counselors, and graduate and medical school students in these disciplines.

Download or read book Comprehensive Handbook of Alcohol Related Pathology written by Victor R. Preedy and published by Elsevier. This book was released on 2004-12-24 with total page 3121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures

Download or read book Alcohol Research Health written by and published by . This book was released on 2002 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aldehyde Dehydrogenases written by Jun Ren and published by Springer. This book was released on 2019-07-31 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.

Download or read book Alcohol and Its Biomarkers written by Amitava Dasgupta and published by Elsevier. This book was released on 2015-02-18 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuses on the analytical methods used to detect alcohol in blood and urine, the limitations of alcohol determination using enzymatic methods, and the differences between clinical and forensic alcohol measurement. Chapters also cover cutting-edge alcohol biomarkers for potential use. Focuses on the analytical methods used for detecting alcohol in blood and urine along with the pitfalls and limitations of alcohol determination using enzymatic methods Explains the difference between clinical and forensic alcohol measurement Includes a brief overview of the benefits of consuming alcohol in moderation and the hazards of heavy drinking

Download or read book Global Status Report on Alcohol and Health 2018 written by World Health Organization and published by World Health Organization. This book was released on 2019-02-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report provides an overview of alcohol consumption and harms in relation to the UN Sustainable Development Goals (Chapter 1) presents global strategies action plans and monitoring frameworks (Chapter 2) gives detailed information on: the consumption of alcohol in populations (Chapter 3); the health consequences of alcohol consumption (Chapter 4); and policy responses at national level (Chapter 5). In its final chapter 6 the imperative for reducing harmful use of alcohol in a public health perspective is presented. In addition the report contains country profiles for WHO Member States and appendices with statistical annexes a description of the data sources and methods used to produce the estimates and references.

Download or read book The Alcohol Hangover written by Joris C Verster and published by MDPI. This book was released on 2021-03-05 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The seeds and fruits (or their parts) of Iberoamerican crops have high nutritional and functional properties which could be utilized in a wide range of foods. The crops included in this book are amaranth (Amaranthus spp.), quinoa (Chenopodium quinoa), kañiwa (Chenopodium pallidicaule), chia (Salvia hispanica L.), Andean maize (Zea mays L.), moringa (Moringa oleifera), yvapuru (Plinia peruviana), kurugua (Sicana odorifera), sacha inchi (Plukenetia huayllabambana), camu camu (Myrciaria dubia), mango (Mangifera indica), tarwi (Lupinus mutabilis), peanut (Arachis hypogaea L.) and taro (Colocasia esculenta), all of them still underutilized. Their cultivation is low; nevertheless, in recent years, the worldwide demand for some of them has increased immensely, resulting in an increase in their production. The ancient Iberoamerican crops have been widely recognized for their nutritional value by food scientists and food producers because they contain high-quality proteins and large quantities of micronutrients such as minerals, vitamins and bioactive compounds. In addition, they are gluten-free, which makes them suitable for people suffering from various gluten intolerances. This book summarizes the large amount of investigations in this field in the last year and provides knowledge within all the relevant areas of food science. The editors hope that this book will contribute to an increased use of these products in human nutrition by consumers worldwide.

Download or read book Alcohol and Cancer written by Vasilis Vasiliou and published by Springer. This book was released on 2018-10-26 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption.

Download or read book Handbook of the Medical Consequences of Alcohol and Drug Abuse written by John Brick and published by Routledge. This book was released on 2012-04-05 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essential newly-expanded reference that needs to be on the desk of every health care professional who encounters substance abusers. Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition is the newly-updated classic reference text that provides even more detailed and expanded information on the pharmacological, toxicological, and neuropsychological consequences of alcohol and drug abuse. Eight new chapters of crucial information have been added. Written by leading experts in the fields of medical physiology, psychopharmacology, and neuropsychology, this valuable resource provides the detailed alcohol and drug information health professionals in all fields need to know. Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition greatly expands on the expert information provided in the first edition. This text provides reviews of the cardiovascular, neurological, pulmonary, gastrointestinal, psychological, and hepatic effects of commonly abused drugs. The book also provides in-depth explanations of the mechanisms by which these psychoactive drugs exert their biobehavioral effects as well as current thinking about—and definitions of—abuse, dependence, and alcohol/drug use. The Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition includes vital information on: alcohol, including definitions of alcohol use, abuse, and dependence the relationship between alcohol and accidental injuries, alcohol’s effect on skeletal and major organ systems, and its effect on risk factors for certain cancers effects of alcohol and other drugs on neuropsychological function the effects of alcohol on neuron signaling, neurotransmitter function, and alcoholic brain damage and cognitive dysfunction fetal alcohol effects chronic effects of marijuana use on psychological and physical health, including a fair and balanced discussion of the medical marijuana issue the consequences of opiate abuse and methadone pharmacotherapy, including a comparison of the effects of methadone and heroin on organ systems cocaine’s history, the various forms of the drug, and the adverse effects of cocaine on cardiovascular, neurologic, and pulmonary systems the medical consequences of inhalants ranging from benzene to xylene the prenatal effects of nicotine, cocaine, marijuana, and opiates terminology that appears in the current literature on alcohol New topics in the Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition include chapters discussing: chemical dependency in psychiatric patients medical consequences of steroids OTC medications hallucinogens health effects of tobacco, nicotine, and exposure to tobacco smoke interactions of alcohol with other drugs and other medications periodontal effects of alcohol and drug abuse in the oral cavity imaging studies of structural brain changes The Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition is an invaluable resource for physicians, scientists, nurses, psychologists, and alcohol and drug counselors.

Download or read book Neuroscience of Alcohol written by Victor R. Preedy and published by Academic Press. This book was released on 2019-03-19 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects