Download or read book Airway Mucus Basic Mechanisms and Clinical Perspectives written by D.F. Rogers and published by Springer Science & Business Media. This book was released on 1997-09-23 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Asthma written by Peter J. Barnes and published by Elsevier. This book was released on 1998-04-20 with total page 973 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field. Comprehensive coverage of both basic science and clinical aspects of asthma Extensively referenced throughout
Download or read book Natural Ventilation for Infection Control in Health care Settings written by Y. Chartier and published by World Health Organization. This book was released on 2009 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guideline defines ventilation and then natural ventilation. It explores the design requirements for natural ventilation in the context of infection control, describing the basic principles of design, construction, operation and maintenance for an effective natural ventilation system to control infection in health-care settings.
Download or read book Clinical and Biological Basis of Lung Cancer Prevention written by Yves Martinet and published by Birkhäuser. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into clinical evaluation, the current impact of molecular diagnostics is profound. The rapidly-evolving diagnostic technologies are revolutionizing basic scientific investigation of cancer, and this trend is expected to soon spill over into the clinical practice of medicine. The evolution of economical diagnostic platforms to allow for direct bronchial epithelial evaluation in high-risk populations promises to improve the diagnostic lead-time for this disease. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin. Chemoprevention, which is designed to intervene in the early phase of carcinogenesis prior to any subjective clinical manifestation of a cancer, is also generating greater research interest. Moreover, the benefit of aerosolized administration of chemoprevention agents over conventional oral administration has strong appeal and may result in the reduction of the incidence of cancer when combined with new diagnostic technologies.
Download or read book Inhalation Aerosols written by Anthony J. Hickey and published by CRC Press. This book was released on 2019-03-21 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.
Download or read book Autoimmune Aspects of Lung Disease written by D.A. Isenberg and published by Springer. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lung forms an integral part of the body's immune system and is subject to a range of diseases which are either autoimmune in nature or have clear-cut immunological abnormalities. "Autoimmune Aspects of Lung Disease" provides a concise review of the lung's role in the immune system and a detailed account of both primary and secondary lung diseases which are characterised by immunological perturbation or frank autoimmunity. The volume presents a detailed, up-to-date account of disorders ranging from infection to neoplasia and is written in both an informative and stimulating style by a prestigious group of authors. The chapters are extensively referenced and provide numerous insights into the aetiopathogenesis and clinical features and treatment of immunologically-linked pulmonary disease. The book is intended as both an overview for physicians and scientists with an established interest in diseases of the lung, immunologists seeking to learn more about relevant disorders in the lung and general physicians, whether specialists or in training, seeking to enrich their knowledge of the links between the pulmonary and immune systems.
Download or read book Mucus Hypersecretion in Respiratory Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2003-07-07 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.
Download or read book Muscarinic Receptors in Airways Diseases written by Johan Zaagsma and published by Springer. This book was released on 2013-03-08 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
Download or read book Clinical Methods written by Henry Kenneth Walker and published by Butterworth-Heinemann. This book was released on 1990 with total page 1128 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the techniques and analysis of clinical data. Each of the seventeen sections begins with a drawing and biographical sketch of a seminal contributor to the discipline. After an introduction and historical survey of clinical methods, the next fifteen sections are organized by body system. Each contains clinical data items from the history, physical examination, and laboratory investigations that are generally included in a comprehensive patient evaluation. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Clinical Management of Chronic Obstructive Pulmonary Disease written by Thomas Similowski and published by CRC Press. This book was released on 2002-04-25 with total page 1117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents a comprehensive review of the most recent strategies used to assess, treat, and manage patients in each phase of chronic obstructive pulmonary disease (COPD)-offering the latest diagnostic modalities to identify and distinguish components of COPD in earlier, more reversible stages. Contains perspectives from the World Health Organization on the epidemiology and control of COPD in Africa, South America, and Eastern Europe!
Download or read book Cellular Mechanisms in Airways Inflammation written by Clive P. Page and published by Birkhäuser. This book was released on 2013-03-11 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.
Download or read book Physiologic Basis of Respiratory Disease written by Qutayba Hamid and published by PMPH-USA. This book was released on 2005 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "the complete text and illustrations ... in fully searchable PDF files."--Page 4 of cover.
Download or read book Cystic Fibrosis written by Julian Allen and published by CRC Press. This book was released on 2016-04-19 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The median age of survival for those with cystic fibrosis has risen considerably in recent years. This text thoroughly examines the developments and breakthroughs which have led to this improvement in life expectancy. With a focus on the latest discoveries in the diagnosis and treatment of the disease, this book provides a comprehensive overview of
Download or read book Rau s Respiratory Care Pharmacology E Book written by Douglas S. Gardenhire and published by Elsevier Health Sciences. This book was released on 2019-06-23 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: You can breathe a little easier knowing there’s a proven way to master respiratory pharmacology! For over 30 years, Rau’s Respiratory Care Pharmacology has been considered the preeminent text on the subject. With easy to grasp terminology, relatable explanations, and reader-friendly writing, the 10th edition simplifies the process of learning pharmacology material like never before. As in previous editions, Rau’s is organized into three logical sections, covering the basics of respiratory care, frequently used drugs, and critical care medications. New to this edition is a Clinical Connections feature that helps you to connect lessons from the book with the clinical setting. Rau’s truly is the best source for preparing you for success on your exams and in professional practice! Learning objectives parallel the levels tested by the NBRC exams to help you to identify important information that goes beyond memorization and recall. Key terms with definitions provide easy access to the pharmacologic vocabulary you should embrace. Key points boxes in each chapter highlight important concepts in the lesson. Full-color design makes the text more reader-friendly and helps you to identify relevant details within an illustration. Self-assessment questions give you the opportunity to test yourself on content learned with thought-provoking questions that require short answers. Clinical scenarios with follow-up SOAP assessment help you to assess your comprehension of the material. Glossary of all key terms in the text aids you in understanding the terminology associated with respiratory care pharmacology. Appendices on common units, systems of measurement, and acceptable mixtures provides references to need-to-know information such as abbreviations, conversion charts for temperatures, liquid metric and solids, and a simple drug compatibility chart for drug mixtures. Alphabetical drug index offers a direct index to look up information based on drug name. NEW! Recently-approved FDA medications help familiarize you with current information. UPDATED All asthma (GINA & NAEPP) and COPD (Gold guidelines) protocols to the latest editions. UPDATED Enhanced readability helps you to more easily understand difficult material. NEW! Clinical Connection boxes helps you to connect what you’ve learned with the clinical setting.
Download or read book Cough written by Kian Fan Chung and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. Cough: Causes, Mechanisms and Therapy is the most comprehensive, up-to-date account of the subject. It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital respiratory units, and will also be of use to interested general practitioners.
