Download or read book Advancing Cancer Care A Deep Dive into Immunotherapy Strategies written by PATHAN AZHER KHAN and published by Pristyn Research Solutions. This book was released on 2024-05-16 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively examines the landscape of immunotherapeutic modalities in cancer treatment, with a specific focus on Chimeric Antigen Receptor (CAR) T-cell therapy, immune checkpoint inhibitors, and other innovative approaches. The CAR T-cell therapy represents a groundbreaking approach wherein T-cells are genetically engineered to recognize and eradicate tumor cells expressing specific antigens. The book briefly discussed the clinical applications and challenges associated with CAR T-cell therapy, case studies highlighting its remarkable efficacy in malignancies, and emerging potential in solid tumors. Additionally, immune checkpoint inhibitors have transformed the treatment of various cancers by disrupting inhibitory signalling pathways and reinvigorating antitumor immune responses. This book explores the mechanisms, clinical efficacy, and challenges of immune checkpoint blockade, including strategies to overcome resistance and improve patient outcomes. Furthermore, it promises other innovative immunotherapeutic strategies, such as tumor vaccines, cytokine therapies, and adoptive cell transfer. Personalized Approaches emphasize their potential synergies and future directions in combination with existing modalities. Overall, this book provides insights into the evolving landscape of cancer immunotherapy, emphasizing the significant strides made in improving patient outcomes and the ongoing efforts to optimize treatment efficacy and durability while minimizing adverse effects.

Download or read book Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-09-05 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response. To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16â€"17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.

Download or read book Advances in Cancer Immunotherapy written by Jasmine Johnson and published by Murphy & Moore Publishing. This book was released on 2021-11-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The stimulation of the immune system through artificial means for the treatment of cancer is known as cancer immunotherapy. It boosts the ability of the immune system to fight cancer cells. It is a subspecialty within oncology. The antibody proteins belonging to the immune system are able to detect the tumor antigens and bind with them. Immunotherapy can be broadly divided into two types, namely, passive immunotherapy and active immunotherapy. The tumor cells are specifically targeted through the immune system in active immunotherapy. Within passive immunotherapy, the cancer cells are not directly attacked by the immunotherapy, but the ability of the immune system to attack cancer cells is enhanced. This book includes some of the vital pieces of work being conducted across the world, on various topics related to cancer immunotherapy. Also included herein is a detailed explanation of the various concepts and applications of this branch of therapy. This book includes contributions of experts and scientists which will provide innovative insights into this field.

Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 1: Intratumoral Signatures Associated With Immune Responsiveness

Download or read book Advancing Healthcare Through Personalized Medicine written by Priya Hays and published by Springer Nature. This book was released on 2021-09-27 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Download or read book Personalized Medicine in Oncology written by Ari VanderWalde and published by Mdpi AG. This book was released on 2022-01-25 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.

Download or read book Frailty in Older Adults with Cancer written by Fabio Gomes and published by Springer Nature. This book was released on 2022-02-15 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes evidence on frailty and ageing, how this may impact patient outcomes and how frailty can be assessed, managed and incorporated in the decision-making process for older patients with cancer. The book aims to: empower clinical teams to assess and support older cancer patients with frailty, ideally within a multidisciplinary setting; and to improve the selection of older cancer patients to the most appropriate management/treatment strategies in order to improve the outcomes of this group of patients often underrepresented in research. The reader will learn the methods available for assessing frailty, such as screening tools, but also how to perform different geriatric assessments covering the different key components (physical, nutritional, social, psychological, etc.). The book also provides information on how to manage and intervene on frailty with the role of pre-habilitation and re-habilitation, how to set-up specialised teams and pathways within one’s hospital and community for these older cancer patients with frailty. Finally, the management of this challenging group of patients according to the cancer type is discussed in detail, alongside with mapping the unmet research needs and future directions in this field.

Download or read book ESMO Handbook written by Dirk Schrijvers and published by CRC Press. This book was released on 2010-05-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 2010. Routledge is an imprint of Taylor & Francis, an informa company.

Download or read book Mistletoe and the Emerging Future of Integrative Oncology written by Steven Johnson and published by Portal Books. This book was released on 2023-05-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human disease is an elaborate dance between behavior, our environment, and chance. Medicine tries to tame human disease with science, but when our knowledge falls short, disease wins. This is too often the case with cancer. We spend billions of dollars each year trying to better understand it and develop tools to ease its effects. Today, many allopathic medical practitioners are beginning to seek out a greater connection with holistic and integrative approaches. The authors of this book introduce one specific therapy and make a case for integrative health in general, including anthroposophically extended medicine, naturopathy, and other holistic approaches. Mistletoe therapy has long been considered a viable treatment for cancer by the European medical community and is beginning to gain recognition in North America, as well. The mistletoe plant possesses many remarkable properties. As a therapy, it represents a rediscovery of ancient wisdom and shows us how the science of modern medicine might expand its reach and reconnect with a more human-centered medicine. The book was structured following the syllabus for a three-day practitioner training hosted by the Physicians' Association for Anthroposophic Medicine (PAAM). The chapters highlight several of our key lectures in a condensed form. The book serves as an introductory summary of--not a replacement for--those intensive professional trainings. This book is constructed as a journey and is meant to be read in its entirety, whether by a patient, a practitioner, a supporter of integrative oncology, or anyone who takes a deep interest in one's own health concerns. The text is accessible, and the reader does not need a science background to understand the majority of the content. While this book should not be considered a treatment or diagnostic manual, it is intended to both prepare practitioners to begin mistletoe therapy training and to make this information available in an accessible form to anyone interested in learning about this approach to treating cancer. Illustrated in color and b/w

Download or read book Application of Bioinformatics in Cancers written by Chad Brenner and published by MDPI. This book was released on 2019-11-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.

Download or read book The Metabolic Approach to Cancer written by Nasha Winters and published by Chelsea Green Publishing. This book was released on 2017 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Optimal Terrain Ten Protocol to Reboot Cellular Health Since the beginning of the twentieth century, cancer rates have increased exponentially--now affecting almost 50 percent of the American population. Conventional treatment continues to rely on chemotherapy, surgery, and radiation to attack cancer cells. Yet research has repeatedly shown that 95 percent of cancer cases are directly linked to diet and lifestyle. The Metabolic Approach to Cancer is the book we have been waiting for--it offers an innovative, metabolic-focused nutrition protocol that actually works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have identified the ten key elements of a person's "terrain" (think of it as a topographical map of our body) that are crucial to preventing and managing cancer. Each of the terrain ten elements--including epigenetics, the microbiome, the immune system, toxin exposures, and blood sugar balance--is illuminated as it relates to the cancer process, then given a heavily researched and tested, non-toxic and metabolic, focused nutrition prescription. The metabolic theory of cancer--that cancer is fueled by high carbohydrate diets, not "bad" genetics--was introduced by Nobel Prize-laureate and scientist Otto Warburg in 1931. It has been largely disregarded by conventional oncology ever since. But this theory is resurging as a result of research showing incredible clinical outcomes when cancer cells are deprived of their primary fuel source (glucose). The ketogenic diet--which relies on the body's production of ketones as fuel--is the centerpiece of The Metabolic Approach to Cancer. Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer--an approach Western medicine does with drug based therapies. Their optimized, genetically-tuned diet shuns grains, legumes, sugar, genetically modified foods, pesticides, and synthetic ingredients while emphasizing whole, wild, local, organic, fermented, heirloom, and low-glycemic foods and herbs. Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). Through addressing the ten root causes of cancer and approaching the disease from a nutrition-focused standpoint, we can slow cancer's endemic spread and live optimized lives.

Download or read book Comprehensive Geriatric Oncology Second Edition written by Lodovico Balducci and published by CRC Press. This book was released on 2004-11-26 with total page 1610 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevention and treatment of cancer in older patients requires an individualized approach, as age causes unpredictable results from patient to patient. Completely revised and updated, the Second Edition of Comprehensive Geriatric Oncology enables clinicians to choose the best possible cancer care. Highlighting newly emerging issues in geriatric oncology, it helps physicians promote cancer prevention. Like its groundbreaking, bestselling predecessor, this new edition exhaustively reviews the biology of cancer and aging, epidemiologic trends, and clinical trials that concern cancer prevention and treatment in the elderly. New chapters contain material on topics such as assessment, fragility, symptom management, and emergencies, and studies the effectiveness of training programs in geriatric oncology. The book addresses issues of healthcare delivery, including cost and evaluation of utility and outcome, suggests new research approaches, reviews existing guidelines for the prevention and treatment of cancer in the elderly, and more. Providing a frame of reference for the ongoing dialogue in the field of geriatric oncology, this is a major reference work for basic, population, and clinical scientists interested in the issue and for practices ministering to older patients.

Download or read book Marine Compounds and Cancer written by Friedemann Honecker and published by MDPI. This book was released on 2018-06-26 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs

Download or read book The Emperor of All Maladies written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2011-08-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Download or read book Stem Cells From Hype to Real Hope written by Khawaja Husnain Haider and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

Download or read book 52 Weekend Adventures in Northern California written by Tom Stienstra and published by Moon Travel. This book was released on 2020-09-15 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Escape to the great outdoors with award-winning expert Tom Stienstra's 52 Weekend Adventures in Northern California. Inside you'll find: The best weekend getaways, hand-picked by the authority on outdoor adventures: Outdoors writer Tom Stienstra reveals his favorite spots, collected over decades of hiking and camping throughout the Golden State Recreation highlights: Immerse yourself in nature with the top options for hiking, backpacking, fishing, biking, boating, and more Expertise and know-how: Tom shares his personal recommendations, insider tips, and memories of his adventures in the great outdoors Planning tools for travelers and locals alike: Make it an easy getaway with detailed driving directions, maps for each adventure, and full-color photos throughout Where to eat and sleep: Discover Tom's favorite spots to grab a bite and find out where to stay on an overnight trip, from campsites to hotels Coverage of the Redwoods, Yosemite, Shasta, Tahoe, Lassen, Sacramento, the Wine Country, the Bay Area, and Monterey and Big Sur Pick a weekend, pack the car, and get outside: Experience the best of NorCal's wilderness with 52 Weekend Adventures in Northern California.

Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike