Download or read book Advances in Understanding the Molecular Biology of Circadian Rhythms in Neurospora Crassa written by Jennifer Elizabeth Compton and published by . This book was released on 2003 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Genetics of Circadian Rhythms written by and published by Academic Press. This book was released on 2011-09-16 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest volume in Advances in Genetics covers the genetics of Circadian rhythms. With an international group of authors this volume is the latest offering in this widely praised series.
Download or read book Molecular Biology of Circadian Rhythms written by Amita Sehgal and published by . This book was released on 2003-10-08 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological, or circadian, clocks govern such functions as sleeping and waking, rest and activity, body temperature, and oxygen consumption. Chronobiology strives to understand how cells generate circadian rhythms through molecular processes of transcription and translation. Drawing on the recent revolutionary advances in biology and genetics, Molecular Biology of Circadian Rhythms presents a comprehensive account of the current state of chronobiology, delivering a ready resource for students and practitioners. Editor Amita Sehgal assembles chapters contributed by leading experts in the molecular analysis of circadian rhythms, representing the state of the art in this emerging discipline. The text begins with a general introduction to biochemical and biophysical aspects of circadian timing, then proceeds to its essential focus on collating the newest information on molecular mechanisms of circadian rhythms. It includes a chapter on the implications for clinical research on affective disorders, sleep disorders, and the relevance for therapeutic treatment, as well as coverage of multiple oscillators and hormonal rhythms. Sections include: Molecular Control of Circadian Rhythms: Animal Models Molecular Control of Circadian Rhythms: From Cyanobacteria to Plants Circadian Organization in Complex Organisms Chapter topics include examinations of circadian rhythms in non-mammalian vertebrates, neurospora, and humans. Advanced undergraduates, graduate students, and medical students in molecular biology, physiology, and neuroscience will appreciate this timely reference.
Download or read book Molecular Biology of Circadian Rhythms written by Amita Sehgal and published by John Wiley & Sons. This book was released on 2004-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text begins with a general introduction to biochemical and biophysical aspects of circadian timing, then proceeds to its essential focus on collating the newest information on molecular mechanisms of circadian rhythms. It includes a chapter on the implications for clinical research on affective disorders, sleep disorders, and the relevance for therapeutic treatment, as well as coverage of multiple oscillators and hormonal rhythms. Sections include: Molecular Control of Circadian Rhythms: Animal Models Molecular Control of Circadian Rhythms: From Cyanobacteria to Plants Circadian Organization in Complex Organisms. Chapter topics include examinations of circadian rhythms in non-mammalian vertebrates, neurospora, and humans.
Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
Download or read book Cellular and Molecular Bases of Biological Clocks written by Leland N. Jr. Edmunds and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: An intriguing class of biological periodicity consists of rhythms with about 24-hour periods occurring at every level of eukaryotic organization. Progress is being made in understanding these rhythms. The six chapters of this work include a brief introduction to circadian (24-hour) rhythms, a survey of circadian organization at the cellular level, and a description of the important microorganisms that have served as experimental models for biochemical analysis. Also considered are relations between cell division cycles and circadian oscillators, as well as some general and theoretical aspects. Where appropriate, parallels are drawn to neuronal oscillators. This volume will introduce and critically appraise modern chronobiology; its extensive illustrations and comprehensive up-to-date bibliography will make it an authoritative reference.
Download or read book Circadian Rhythms written by Ezio Rosato and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an in-depth examination of circadian biology, presented by leading researchers in the field. Methods for analysis of rhythmic readouts in select model organisms are included. This cutting-edge collection of protocols is adaptable for research at every level, and represents the huge strides that chronobiologists have made over the past two decades. Circadian biologists at all research levels will realize tremendous benefit from this extraordinary collection.
Download or read book Circadian Clocks and Their Adjustment written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans.
Download or read book Circadian Rhythm written by Mohamed A. El-Esawi and published by BoD – Books on Demand. This book was released on 2018-07-04 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.
Download or read book Natural Variation and Clocks written by and published by Academic Press. This book was released on 2017-10-19 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Variances and Clocks, Volume 99 in the Advances in Genetics series provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natural variation and genetics of the photoperiodic timer in the pitcher-plant mosquito, Natural variation in human clocks, and Natural variation in the circadian clock genes in Drosophila and other insects. This series continually publishes important reviews that are ideal for geneticists and their colleagues in affiliated disciplines, critically analyzing future directions. Critically analyzes future directions for the study of clinical genetics Written and edited by recognized leaders in the field Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics
Download or read book Understanding Circadian Output Networks in Neurospora Crassa written by Rigzin N. Dekhang and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurospora crassa circadian clock is based on a highly regulated molecular negative feedback loop, similar to molecular clocks in all eukaryotes. A core component of the N. crassa molecular clock is the White Collar complex (WCC), composed of the blue light photoreceptor WC-1 and its partner WC-2. The WCC serves as a master regulator that controls light signaling, and the precise timing of target gene expression. Up to 40% of the eukaryote genome is under the control of the clock at the level of transcript abundance, but the molecular links between the core oscillator and downstream target genes, as well as the mechanisms controlling the phase of rhythmic gene expression, are not understood. Using chromatin immunoprecipitation coupled to high-throughput sequencing (ChIP-seq), about 400 binding sites for the WCC were identified throughout the N. crassa genome. We found that 24 transcription factors (TFs) were significantly enriched among the direct WCC target genes. As expected for genes that are controlled by the WCC, the first-tier TFs are both clock- and light-regulated. These data led to the hypothesis that the WCC functions to control rhythms in TFs, which in turn control rhythmicity and phase of downstream target genes and processes. To test this hypothesis, the first-tier TF ADV-1 (Arrested Development-1) was investigated in detail to characterize the downstream circadian genetic network. ADV-1 target genes were identified using ChIP- and RNA-seq, and as expected many ADV-1 downstream target genes were light-responsive and/or clock-controlled. An enrichment for ADV-1 target genes involved in cell fusion, a process that is critical for normal vegetative and sexual development in N. crassa, provided a rationale for the observed developmental defects in ADV-1 deletion cells, and suggested that cell fusion is clock-controlled. Importantly, this work revealed that the transduction of time-of-day information through ADV-1 to its downstream targets is more complex than anticipated. Specifically, I show that deletion of ADV-1 does not always lead to predicted changes in rhythmic gene expression and/or phase, suggesting that ADV-1 functions in combination with other first-tier TFs to control rhythmicity. In support of this idea, genome-wide binding profiles of all of the first-tier TFs uncovered complex feedback and feed forward regulation involving ADV-1. Thus, my data revealed that in order to fully understand how the clock signals phase information to downstream targets, we need to go beyond the candidate gene approach, and instead develop computational models from our TF ChIP-seq and rhythmic transcriptome data to model how time of day information is transduced in the molecular circadian output gene network. Predictions of the model can then be validated using ADV-1 deletion cells alone, or in combination with deletion of other first-tier TFs in the network, with the goal of deriving design principles that define conserved aspects of the circadian output network in all eukaryotes, and important in human health. To test this hypothesis, the first-tier TF ADV-1 (Arrested Development-1) was investigated in detail to characterize the downstream circadian genetic network. ADV-1 target genes were identified using ChIP- and RNA-seq, and as expected many ADV-1 downstream target genes were light-responsive and/or clock-controlled. An enrichment for ADV-1 target genes involved in cell fusion, a process that is critical for normal vegetative and sexual development in N. crassa, provided a rationale for the observed developmental defects in ADV-1 deletion cells, and suggested that cell fusion is clock- controlled. Importantly, this work revealed that the transduction of time-of-day information through ADV-1 to its downstream targets is more complex than anticipated. Specifically, I show that deletion of ADV-1 does not always lead to predicted changes in rhythmic gene expression and/or phase, suggesting that ADV-1 functions in combination with other first-tier TFs to control rhythmicity. In support of this idea, genome-wide binding profiles of all of the first-tier TFs uncovered complex feedback and feed forward regulation involving ADV-1. Thus, my data revealed that in order to fully understand how the clock signals phase information to downstream targets, we need to go beyond the candidate gene approach, and instead develop computational models from our TF ChIP-seq and rhythmic transcriptome data to model how time of day information is transduced in the molecular circadian output gene network. Predictions of the model can then be validated using ADV-1 deletion cells alone, or in combination with deletion of other first-tier TFs in the network, with the goal of deriving design principles that define conserved aspects of the circadian output network in all eukaryotes, and important in human health. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155195
Download or read book Understanding the Genetic Basis of Natural Variation in the Regulation of Circadian Clock of Neurospora Crassa written by Tae Sung Kim and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian clock has been found in all forms of life from bacteria to humans. Its biological function is thought to provide organisms with time keeping ability, which enables organisms to control their behavioral, physiological and cellular activities efficiently on daily basis environmental changes. Over the past four decades, Neurospora crassa has been developed as a model organism for the study of circadian clocks. However, despite the intensive molecular characterizations of the Neurospora circadian clock, our understanding of this system is far from comprehensive. Quantitative Trait Loci (QTL) analyses, using natural strains, have been successfully utilized over the past decade to dissect complex traits down to a naturally occurring polymorphism that is relevant to phenotypic variations. The high quality genomic sequence and sophisticated molecular biology tools, in combination with the QTL analysis, may make it possible to increase the understanding of mechanisms of circadian regulation and may also provide insights into the biological role of the circadian clock, especially in the process of adapting to local environments, a topic that is somewhat overlooked in current research. In this work, I have explored an alternative strategy to uncover new perspectives in the Neurospora circadian clock. My research has laid the groundwork for QTL analysis and has demonstrated QTL analysis of the clock phenotypes, period and entrained phase using natural populations. In chapter II, I describe the computational, statistical and genetic analyses performed to evaluate the marker potential of Neurospora simple sequence repeat (SSR) and to investigate the biological role of the SSR In chapter III, I describe the research regarding the development of two important bioinformatic tools which include 1) a genetic marker management system which facilitates QTL analysis and subsequent positional cloning steps, and 2) an automatic image processing system for the Neurospora circadian clock phenotype. Lastly, in chapter IV, I describe the results of QTL analysis for the two clock phenotypes (period, phase) in three natural F1 populations using two independent statistical methods. Subsequently, I confirmed the QTL effects of one of those in the BC4 generation which were predicted from the F1 populations by constructing near isogenic lines (NIL).
Download or read book Genetic and Molecular Analysis of Circadian Clock Genes in Neurospora Crassa written by Louis W. Morgan and published by . This book was released on 1999 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics and Biotechnology written by J. Philipp Benz and published by Springer Nature. This book was released on 2020-10-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised third edition includes up-to-date topics and developments in the field, which has made tremendous strides since the publication of the second edition in 2004. Many novel techniques based on Next Generation Sequencing have sped up the analysis of fungi and major advances have been made in genome editing, leading to a deeper understanding of the genetics underlying cellular processes as well as their applicability. At the same time, the relevance of fungi is unbroken, both due to the serious threats to human health and welfare posed by fungal pests and pathogens, and to the many benefits that fungal biotechnology can offer for diverse emerging markets and processes that form the basis of the modern bioeconomy. With regard to these advances, the first section of this volume, Genetics, illustrates the basic genetic processes underlying inheritance, cell biology, metabolism and “lifestyles” of fungi. The second section, Biotechnology, addresses the applied side of fungal genetics, ranging from new tools for synthetic biology to the biotechnological potential of fungi from diverse environments. Gathering chapters written by reputed scientists, the book represents an invaluable reference guide for fungal biologists, geneticists and biotechnologists alike.
Download or read book Advances in Genetics written by Jeffrey C. Hall and published by Elsevier. This book was released on 2007-05-07 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes imporatnt reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
Download or read book The Rhythms Of Life written by Leon Kreitzman and published by Profile Books. This book was released on 2011-09-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.
Download or read book Pharmacoepigenetics written by and published by Academic Press. This book was released on 2019-06-04 with total page 983 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
