Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Download or read book Extracellular Matrix in Development and Disease written by Jeffrey H. Miner and published by Elsevier. This book was released on 2005-11-18 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more

Download or read book Planar Cell Polarization during Development written by and published by Elsevier Science. This book was released on 2005-07-26 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular polarization is key to all cellular functions. Our perceptions, which are derived from our senses, depend on the proper cellular polarization of our sense organs, such as the eyes or ears. Much of this book examines the different aspects in cellular polarization and its researched role in the Drosophila, where the first planar cellular polarity (PCP) gene was discovered over 20 years ago. Topics also include: From flies to man: how we are polarized, Marking an embryo work, Cellular polarization at its functional best, Hearing and seeing your environment, and From a cell to an organ. This series represents timely issues in developmental biology. It provides annual reviews of selected topics, written from the perspectives of leading investigators in the field of development. * Presents many various organisms such as flies, fish, frogs and mice * Offers over 40 exceptional illustrations * First of its kind to include new data and detailed models on cell planar polarization

Download or read book Advances in Evolutionary Developmental Biology written by J. Todd Streelman and published by John Wiley & Sons. This book was released on 2013-10-17 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing outstanding breadth of coverage in evo-devo, Advances in Evolutionary Developmental Biology provides a comprehensive review of the milestones of research in evolution and development and outlines the exciting research agenda for the field going forward. Compiling the viewpoints of a diverse group of field experts, this timely text expands the now-mature science of evo-devo into more complex areas of research. This essential reference is destined to become the go-to source for ideas and hypotheses for a new generation of graduate students in evolutionary and developmental biology.

Download or read book Plant Development and Evolution written by and published by Academic Press. This book was released on 2019-01-04 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Development and Evolution, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Evolution of the plant body plan, Lateral root development and its role in evolutionary adaptation, the Development of the vascular system, the Development of the shoot apical meristem and phyllotaxis, the Evolution of leaf diversity, the Evolution of regulatory networks in land plants, The role of programed cell death in plant development, the Development and evolution of inflorescence architecture, the Molecular regulation of flower development, the Pre-meiotic another development, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Plant Development and Evolution

Download or read book Wnt Signaling in Embryonic Development written by Sergei Y. Sokol and published by Elsevier. This book was released on 2011-09-22 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes. * Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton* Offers insight to large genomic data that are now available for the analysis of Wnt gene targets* Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity

Download or read book Advances in Developmental Biology written by Paul M. Wassarman and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Essential Developmental Biology written by Jonathan M. W. Slack and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Developmental Biology is a comprehensive, richly illustrated introduction to all aspects of developmental biology. Written in a clear and accessible style, the third edition of this popular textbook has been expanded and updated In addition, an accompanying website provides instructional materials for both student and lecturer use, including animated developmental processes, a photo gallery of selected model organisms, and all artwork in downloadable format. With an emphasis throughout on the evidence underpinning the main conclusions, this book is an essential text for both introductory and more advanced courses in developmental biology. Shortlisted for the Society of Biology Book Awards 2013 in the Undergraduate Textbook category. Reviews of the Second Edition: "The second edition is a must have for anyone interested in development biology. New findings in hot fields such as stem cells, regeneration, and aging should make it attractive to a wide readership. Overall, the book is concise, well structured, and illustrated. I can highly recommend it." —Peter Gruss, Max Planck Society "I have always found Jonathan Slack's writing thoughtful, provocative, and engaging, and simply fun to read. This effort is no exception. Every student of developmental biology should experience his holistic yet analytical view of the subject." —Margaret Saha, College of William & Mary

Download or read book Murine Homeobox Gene Control of Embryonic Patterning and Organogenesis written by Thomas Lufkin and published by Elsevier. This book was released on 2003-12-03 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first homeobox gene was molecular cloned nearly two decades ago, and since that time tremendous progress has been made in our understanding of the distribution of homeobox genes in the genomes of many animal species and the common functional role the encoded homeodomains play in cell-type specification, morphogenesis and development. The amino acid sequence of the homeodomain, as well as the presence of other conserved protein domains, has allowed the classification of homeodomain-containing proteins (homeoproteins) into over thirty separate families (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). In many cases a single gene has been shown to fully direct the morphogenesis and development of a complex tissue, organ or even an entire body segment. Yet how this "master" regulatory ability of homeoproteins functions at the molecular level to a large degree still remains a mystery, in part owing to our limited understanding of the nature of both homeoprotein transcriptional cofactors and even more elusively, the downstream targets of homeoprotein function. In the reviews presented here it is limited primarily to what has been learned in vertebrate systems, principally focusing on the mouse, owing to the strengths of the technical approaches currently existing in murine developmental genetics that are not yet available to the same degree in other vertebrate species. Despite this mammalian predilection, a common thread to each of these reviews is the underlying importance of what has been learned about homeoprotein function in other animal species, particularly arthropods like Drosophila.

Download or read book Developmental Biology and Musculoskeletal Tissue Engineering written by Martin J. Stoddart and published by Academic Press. This book was released on 2018-04-24 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Download or read book Keywords and Concepts in Evolutionary Developmental Biology written by Brian K. Hall and published by Harvard University Press. This book was released on 2006-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering more than 50 central terms and concepts in entries written by leading experts, this book offers an overview of this new subdiscipline of biology, providing the core insights and ideas that show how embryonic development relates to life-history evolution, adaptation, and responses to and integration with environmental factors.

Download or read book Advances in Stem Cell Research written by Hossein Baharvand and published by Springer Science & Business Media. This book was released on 2012-05-26 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Download or read book Developmental Biology A Very Short Introduction written by Lewis Wolpert and published by Oxford University Press. This book was released on 2011-08-25 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.

Download or read book Cardiovascular Development written by Rolf Bodmer and published by Elsevier. This book was released on 2007-11-13 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms. Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field. * Ties together the development of heart morphology and conduction system * The latest developments in vertebrate and invertebrate genetic model systems * Technological advancements in cardiovascular science

Download or read book ScienceDirect Life Sciences Book Series written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Strategy for Research in Space Biology and Medicine in the New Century written by National Research Council and published by National Academies Press. This book was released on 1998-09-16 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Construction of the international space station, scheduled to start in late 1998, ushers in a new era for laboratory sciences in space. This is especially true for space life sciences, which include not only the use of low gravity as an experimental parameter to study fundamental biological processes but also the study of the serious physiological changes that occur in astronauts as they remain in space for increasingly longer missions. This book addresses both of these aspects and provides a comprehensive review of ground-based and space research in eleven disciplines, ranging from bone physiology to plant biology. It also offers detailed, prioritized recommendations for research during the next decade, which are expected to have a considerable impact on the direction of NASA's research program. The volume is also a valuable reference tool for space and life scientists.

Download or read book Evolutionary Developmental Biology of Crustacea written by Gerhard Scholtz and published by CRC Press. This book was released on 2003-06-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crustaceans, due to the great diversity of their body organization, segmentation patterns, tagmatization, limb types, larval forms, cleavage, and gastrulation modes, are highly desirable for the study of questions at the interface of evolution and development. Modern interest in evolutionary developmental biology (evo-devo) rests on the molecular genetic approach and a variety of molecular techniques have proven fruitful when performed on crustaceans. Evolutionary Developmental Biology of Crustacea presents a comprehensive treatment of all aspects of the field, beginning with a discussion of the implications of the typological Bauplan and phylum concepts versus historical concepts such as ground pattern and monophylum for the formulation of conceptual questions in evo-devo. Following this, the authors present the results of Hox gene expression in various crustacean taxa, aspects of segment formation at the cellular and genetic levels, the formation of segmental structures such as neurons, ganglia, and limbs, and the role of morphological ontogenetic characters in resolving phylogenetic relationships. By covering so many general aspects of crustacean development, morphology, and evolution, Evolutionary Developmental Biology of Crustacea serves as an indispensable reference for developmental and evolutionary biologists investigating the role of genetics in evolution and development.