Download or read book Advances in Chemistry and Biology of Nitric Oxide 2007 written by and published by . This book was released on 2007 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Chemistry and Biology of Nitric Oxide written by Maria Sofia Giménez and published by . This book was released on 2007-01-01 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the present book is covers a variety of topics related to complex function of NO and their biological function, through the presentation of results obtained for researchers that have study its. Nitric oxide (NO) is a ubiquitous biological messenger involved in a variety of physiological processes that acts as a signal transducer but also exerts a variety of regulatory and cytostatic functions. Nitric oxide synthases (NOSs) are flavohaem enzymes that function broadly in human health and disease. Also, peroxynitrite is a powerful oxidant formed from the reaction between nitric oxide and superoxide anion that could participate in the mechanism of toxicity of different metals. Also, Nitric oxide (NO) is a potent vasodilator and signal modulator molecule. Enhanced oxidative stress is involved in mediating the endothelial dysfunction. In particular, the endothelium-dependent relaxation mediated by eNOS declines with oxidative stress. The endothelial cells are exposed to high concentration of circulating all-trans retinoic acid (atRA), a natural retinoid derived from vitamin A, whereby the relation between nitric oxide and vitamin A on vascular system is discussed. Furthermore, in the kidney, NO promotes natriuresis and diuresis and NO plays an important role in the renal adaptation to variations of dietary salt intake. Reduction of NO production in the renal medulla, either pharmacologically or genetically, has a great impact on the delivery of blood to the medulla and on the long-term regulation of sodium excretion and blood pressure. The adrenal gland expresses the neuronal and the endothelial isoforms of nitric oxide synthase and the nitric oxide produced into the adrenal cells modulates negatively the production of glucocorticoids. The effect and the mechanism of action of nitric oxide in the regulation of adrenal zona fasciculate function is descripted. Different authors have reported that macrophages, neutrophils and pulmonary epithelial cell, among the other contribute significantly to inducible form of nitric oxide synthase (iNOS) expression resulting in enhanced NO production in the lung in different situations. The implications of NO generation in lung illness, which are significant cause of morbidity and mortality in man, are evaluated. NO has an essential role as a physiological regulator of the respiratory chain provides a hypothesis to fill the gap between the observations previously mentioned. In particular, NO steady-state level is one of the factors that have been proposed to be determining in heart adaptation to hypoxia. Up-regulation of heart mitochondrial NOS during acclimatization to hypobaric hypoxia was associated to the preservation of contractile parameters and tolerance to O2 deprivation. Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been shown to be involved in various arthritis in a complex manner. Expression of iNOS is induced following exposure to proinflammatory cytokines and bacterial products. A vast amount of evidence implicates NO as mediator of inflammation and/or tissue destruction in arthritic disorders. Nitric oxide (NO) fulfills important functions during pregnancy: implantation, decidualization, vasodilatation and myometrial relaxation. However, in high concentrations such as the ones that are produced in sepsis, it has toxic effects since it is a free radical. The texts not only give an overview of advances made in the area, but also can stimulate the imagination of scientist and increased the interest by studying the function of NO in the health and disease.
Download or read book Biochemistry Molecular Biology and Therapeutic Implications written by and published by Academic Press. This book was released on 1995-11-29 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction
Download or read book Nitric Oxide written by Louis J. Ignarro and published by Academic Press. This book was released on 2009-11-05 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Edited by Nobel Laureate Louis J. Ignarro Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
Download or read book Nitric Oxide Donors written by Peng George Wang and published by John Wiley & Sons. This book was released on 2005-08-16 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
Download or read book Life Death and Nitric Oxide written by Anthony R Butler and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designated 'Molecule of the Year' in 1992 in recognition of its many biological roles, nitric oxide has wide significance in the world around us and the story of nitric oxide is still unfolding. This small and seemingly innocent molecule has for many years been known to play a significant role in both the creation of photochemical smogs and in the nitrogen cycle. It has an interesting chemistry as a metal ligand, and the bonding within the nitric oxide molecule has been extensively studied. More recently, the molecule has been in the spotlight for the role it plays in controlling blood flow, in the immune system and in brain activity. Life, Death and Nitric Oxide covers many of the topics relating to nitric oxide, from smog and catalytic converters to tumour growth, blood flow and Viagra, with the aim of finding out why such a simple molecule can do so much.
Download or read book Nitric Oxide written by Louis J. Ignarro and published by Academic Press. This book was released on 2000-09-13 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
Download or read book Nitric Oxide in Health and Disease written by Jill Lincoln and published by Cambridge University Press. This book was released on 1997-08-28 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.
Download or read book Nitric Oxide written by Louis Ignarro and published by . This book was released on 1995 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Highlights * Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide * Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases * Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction
Download or read book Cellular and Molecular Biology of Nitric Oxide written by Jeffrey D. Laskin and published by CRC Press. This book was released on 1999-02-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides the latest advances in the explosive growth of nitric oxide (NO) study-covering the behavior of this highly reactive molecule in a wide variety of physiologicial processes, including respiration, blood pressure, neurotransmission, nospecific host defense, and wound healing."
Download or read book Nitrosation Reactions and the Chemistry of Nitric Oxide written by D.L.H. Williams and published by Elsevier. This book was released on 2004-12-16 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry* Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres* Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols
Download or read book The Biology of Subcellular Nitric Oxide written by Tamás Rőszer and published by Springer Science & Business Media. This book was released on 2012-01-14 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
Download or read book Nitric Oxide Research from Chemistry to Biology written by Yann A. Henry and published by Springer Science & Business Media. This book was released on 1997 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Biology of Nitric Oxide written by Katrina Miranda and published by Garland Science. This book was released on 2008-03 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Research Developments in Chemistry and Biology of Nitric Oxide 2008 written by Valeria Sorrenti and published by . This book was released on 2008-01-01 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preface In the last two decades knowledge of organometallic compounds has expanded so rapidly that it constitutes a major branch of chemistry. Almost all branches of chemistry and material science now interface with organometallic chemistry--the study of compounds containing carbon-metal bonds. The subject is developing at an astonishing rate and in many directions. This book deals mainly with some structural aspects of organoboron and organosilicon and applications of organometallic compounds in carbonylation reactions. First two chapters describe some structural aspects of organoboron and organosilicon compounds. Chapter 1 describe the Macrocyclic boron species, synthesis and their stabilization through N-B dative bond. Chapter 2 reviews the structural determination of some hypervalent silicon compounds by NMR and X-ray diffaraction studies. Chapter 3 deals with recent trends in cobalt catalysed carbonylation reactions while chapter 4 describes the transition metal mediated cyclocarbonylation with special reference to alkynes, alkynyl ketones and enones derivatives. Last chapter reviews the synthesis of organometallic dendrimers and summarizes the application of organometallic dendritic molecules in catalysis with special reference to carbonylation and ring expansion reaction in organic synthesis.
Download or read book Nitric Oxide written by Jack Lancaster, Jr. and published by Academic Press. This book was released on 1996-08-01 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique sourcebook serves as a comprehensive reference, bridging the well-established chemistry of nitric oxide and the new and exciting role of nitric oxide as an effector and signaling molecule in numerous biological systems. Nitric Oxide: Principles and Actions relates the chemical properties of the molecule to its possible effects on biological systems, under both normal physiological and pathophysiological conditions. Combining the chemistry and analysis of nitric oxide with newer studies of the relevance of the molecule gives this book a long life, making it extremely useful to researchers in a number of areas. Provides a much needed compilation of what is known about nitric oxide and its properties Enables researchers to understand the importance and use of nitric oxide in systems of study Covers an area of tremendous growth in research Provides the first collection of the roles of nitric oxide in microbial and mammalian systems and as a probe of metalloenzymes Presents the historically important role of nitric oxide in food preservation
Download or read book Nitric Oxide in Plant Growth Development and Stress Physiology written by Lorenzo Lamattina and published by Springer Science & Business Media. This book was released on 2007-01-30 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in the study of nitric oxide (NO) biology, biochemistry, molecular biology, and physiology in plants. It provides an overview of current understanding of the NO actions involved in adaptive responses of plant fitness to environmental constraints. Coverage places special emphasis on NO-dependent signaling, molecular adjustments, and targets as key elements in plant growth, development, and stress physiology.
