Download or read book Advancement of Neural Interfaces to Probe Network Electrophysiology written by Greta Thompson-Steckel and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Network Electrophysiology written by Makoto Taketani and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Network Electrophysiology: Using Multi Electrode Arrays explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. It reviews the recent progress in both electronics and computational tools developed to analyze the functional operations of large ensembles of neurons using multi-electrode arrays and in vitro preparations. In addition, it gives readers a sense of the applications made possible by these technological tools. This volume is the reference for researchers, industry, graduate students, and postdoctoral fellows in all areas of neuroscience, cognitive neuroscience, pharmaceutical science, and bioengineering.

Download or read book Silicon Integrated Neuromorphic Neural Interfaces written by Jun Wang and published by . This book was released on 2019 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromorphic engineering pursues the design of electronic systems emulating function and structural organization of biological neural systems in silicon integrated circuits that embody similar physical principles. The work in this dissertation extends neuromorphic engineering to neural interfaces that directly couple biological neurons to their equivalents in silicon integrated circuits, dynamically probing their function through silicon emulation of biophysical chemical and electrical synapses. Our aim in this work is to enable study of hybrid networks of biological and silicon neurons with highly configurable topology and biophysically based properties, providing windows on the inner workings of biological neural circuits from the cellular to the network levels, and hence promoting new synergies between theory in computational neuroscience and experimentation in systems neuroscience. In the first part, membrane dynamics and ion channel kinetics of biological neurons, obtained from experimental electrophysiological data, were accurately mapped onto equivalent continuous-time analog dynamics in NeuroDyn, a highly reconfigurable neuromorphic silicon microchip. To this end, songbird individual neuron dynamics from intracellular neural recordings were extracted, modeled, and then mapped onto silicon neurons in NeuroDyn by data assimilation to estimate and configure biophysical parameters. Further, the NeuroDyn framework was extended to serve as a versatile tool for biophysical dynamic clamp electrophysiology, connecting biological and silicon neurons through synthetic virtual chemical synapses. To this end, the response properties of five different types of chemical synapses, including both excitatory (AMPA, NMDA) and inhibitory (GABAA, GABAC, Glycine) ionotropic receptors were reproduced with neuromorphic integrated circuits. In addition, electrical synapses (gap junctions) were emulated in a network of four silicon neurons. The second part entails the design, implementation and functional validation of high-density multi-channel neural interfaces, establishing bidirectional electrical communication between silicon artificial neurons and biological neurons at very large scale. Our work produced a neural interface system-on-chip (NISoC) with 1,024-channels of simultaneous electrical recording and stimulation at record noise-energy efficiency, with sub-[mu]W power consumption per channel at 6 [mu]Vrms input referred voltage noise over 12.5 kHz signal bandwidth. Integrating an array of 32 × 32 electrodes on a 2mm × 2mm chip in 65nm CMOS, the NISoC supports both voltage and current clamping through a programmable interface, ranging 100~dB in voltage, and 120~dB in current, for high-resolution high-throughput electrophysiology. Further, we demonstrated extended functionality for scalable multichannel in vitro intracellular electrophysiology in a second 256-channel hybridized NiSoC with sharp-tipped Pt nanowire electrodes deposited on the silicon top-metal surface, recording action potentials from rat cortical neurons cultured directly on top of the chip. These advances combine to enable bidirectional communication between artificial neurons and biological neurons in vitro, with precise probing of neural function and flexible control over synaptic interactions ranging from intracellular dynamics of individual cells to network dynamics comprising potentially thousands of neurons. In addition to applications in closed-loop electrophysiology, in vitro neuromorphic neural interface can be used as testbed for prototyping the next generation of neuroprosthetics.

Download or read book Closing the Loop Around Neural Systems written by Steve M Potter and published by Frontiers Media SA. This book was released on 2014-12-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.

Download or read book Taschenbuch der medizinisch klinischen Diagnostik written by Friedrich von Müller and published by . This book was released on 1989 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bridging the Gap in Neuroelectronic Interfaces written by Jeffrey R. Capadona and published by Frontiers Media SA. This book was released on 2020-07-09 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neural Interface Engineering written by Liang Guo and published by Springer Nature. This book was released on 2020-05-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.

Download or read book In Vitro Neuronal Networks written by Michela Chiappalone and published by Springer. This book was released on 2019-05-09 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.

Download or read book Quantitative Biology Dynamics of Living Systems written by Noriko Hiroi and published by Frontiers Media SA. This book was released on 2017-07-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required. Quantities are not only the bridge between mathematical description and biological observations; they often stand as essential elements similar to genome information in genetics. This important realization has greatly rejuvenated research in the area of Quantitative Biology. Because of the increased need for precise quantification, a new era of technological development has opened. For example, spatio-temporal high-resolution imaging enables us to track single molecule behavior in vivo. Clever artificial control of experimental conditions and molecular structures has expanded the variety of quantities that can be directly measured. In addition, improved computational power and novel algorithms for analyzing theoretical models have made it possible to investigate complex biological phenomena. This research topic is organized on two aspects of technological advances which are the backbone of Quantitative Biology: (i) visualization of biomolecules, their dynamics and function, and (ii) generic technologies of model optimization and numeric integration. We have also included articles highlighting the need for new quantitative approaches to solve some of the long-standing cell biology questions. In the first section on visualizing biomolecules, four cutting-edge techniques are presented. Ichimura et al. provide a review of quantum dots including their basic characteristics and their applications (for example, single particle tracking). Horisawa discusses a quick and stable labeling technique using click chemistry with distinct advantages compared to fluorescent protein tags. The relatively small physical size, stability of covalent bond and simple metabolic labeling procedures in living cells provides this type of technology a potential to allow long-term imaging with least interference to protein function. Obien et al. review strategies to control microelectrodes for detecting neuronal activity and discuss techniques for higher resolution and quality of recordings using monolithic integration with on-chip circuitry. Finally, the original research article by Amariei et al. describes the oscillatory behavior of metabolites in bacteria. They describe a new method to visualize the periodic dynamics of metabolites in large scale cultures populations. These four articles contribute to the development of quantitative methods visualizing diverse targets: proteins, electrical signals and metabolites. In the second section of the topic, we have included articles on the development of computational tools to fully harness the potential of quantitative measurements through either calculation based on specific model or validation of the model itself. Kimura et al. introduce optimization procedures to search for parameters in a quantitative model that can reproduce experimental data. They present four examples: transcriptional regulation, bacterial chemotaxis, morphogenesis of tissues and organs, and cell cycle regulation. The original research article by Sumiyoshi et al. presents a general methodology to accelerate stochastic simulation efforts. They introduce a method to achieve 130 times faster computation of stochastic models by applying GPGPU. The strength of such accelerated numerical calculation are sometimes underestimated in biology; faster simulation enables multiple runs and in turn improved accuracy of numerical calculation which may change the final conclusion of modeling study. This also highlights the need to carefully assess simulation results and estimations using computational tools.

Download or read book Biomedical Information Technology written by David Dagan Feng and published by Academic Press. This book was released on 2019-10-22 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Information Technology, Second Edition, contains practical, integrated clinical applications for disease detection, diagnosis, surgery, therapy and biomedical knowledge discovery, including the latest advances in the field, such as biomedical sensors, machine intelligence, artificial intelligence, deep learning in medical imaging, neural networks, natural language processing, large-scale histopathological image analysis, virtual, augmented and mixed reality, neural interfaces, and data analytics and behavioral informatics in modern medicine. The enormous growth in the field of biotechnology necessitates the utilization of information technology for the management, flow and organization of data. All biomedical professionals can benefit from a greater understanding of how data can be efficiently managed and utilized through data compression, modeling, processing, registration, visualization, communication and large-scale biological computing. - Presents the world's most recognized authorities who give their "best practices" - Provides professionals with the most up-to-date and mission critical tools to evaluate the latest advances in the field - Gives new staff the technological fundamentals and updates experienced professionals with the latest practical integrated clinical applications

Download or read book Nanotechnology and Neuroscience Nano electronic Photonic and Mechanical Neuronal Interfacing written by Massimo De Vittorio and published by Springer. This book was released on 2014-07-08 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the “nano-world” can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.

Download or read book Augmentation of Brain Function Facts Fiction and Controversy written by Mikhail Lebedev and published by Frontiers Media SA. This book was released on 2018-09-14 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.

Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Download or read book Lab on Fiber Technology written by Andrea Cusano and published by Springer. This book was released on 2014-07-29 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the “lab-on-fiber” technology. Inspired by the well-established "lab on-a-chip" concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications. Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate description of the main developments and achievements in the lab-on-fiber technology roadmap, also highlighting the new perspectives and challenges to be faced. This book is essential for scientists interested in the cutting-edge fiber optic technology, but also for graduate students.

Download or read book Nanowires written by Anqi Zhang and published by Springer. This book was released on 2016-07-26 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive summary of nanowire research in the past decade, from the nanowire synthesis, characterization, assembly, to the device applications. In particular, the developments of complex/modulated nanowire structures, the assembly of hierarchical nanowire arrays, and the applications in the fields of nanoelectronics, nanophotonics, quantum devices, nano-enabled energy, and nano-bio interfaces, are focused. Moreover, novel nanowire building blocks for the future/emerging nanoscience and nanotechnology are also discussed.Semiconducting nanowires represent one of the most interesting research directions in nanoscience and nanotechnology, with capabilities of realizing structural and functional complexity through rational design and synthesis. The exquisite control of chemical composition, morphology, structure, doping and assembly, as well as incorporation with other materials, offer a variety of nanoscale building blocks with unique properties.

Download or read book Research Anthology on Artificial Neural Network Applications written by Management Association, Information Resources and published by IGI Global. This book was released on 2021-07-16 with total page 1575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial neural networks (ANNs) present many benefits in analyzing complex data in a proficient manner. As an effective and efficient problem-solving method, ANNs are incredibly useful in many different fields. From education to medicine and banking to engineering, artificial neural networks are a growing phenomenon as more realize the plethora of uses and benefits they provide. Due to their complexity, it is vital for researchers to understand ANN capabilities in various fields. The Research Anthology on Artificial Neural Network Applications covers critical topics related to artificial neural networks and their multitude of applications in a number of diverse areas including medicine, finance, operations research, business, social media, security, and more. Covering everything from the applications and uses of artificial neural networks to deep learning and non-linear problems, this book is ideal for computer scientists, IT specialists, data scientists, technologists, business owners, engineers, government agencies, researchers, academicians, and students, as well as anyone who is interested in learning more about how artificial neural networks can be used across a wide range of fields.

Download or read book Living Machines written by Tony J. Prescott and published by Oxford University Press. This book was released on 2018 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary research in the field of robotics attempts to harness the versatility and sustainability of living organisms with the hope of rendering a renewable, adaptable, and robust class of technology that can facilitate self-repairing, social, and moral--even conscious--machines. This landmark volume surveys this flourishing area of research.