Download or read book Adrenergic Mechanisms in Myocardial Ischemia written by G. Heuch and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress-induced myocardial ischemia is a frequent manifestation of coronary heart disease, and sympathetic activation is an important precipitating and aggravating factor in such stress induced ischemia. However, the complex interplay between the sympathetic initiation of myocardial ischemia, ischemia-induced alterations in sympathetic neurotransmission, as well as changes in adrenoceptor density and post-receptor signal transduction that can occur during ischemia remains incompletely understood. Not only the activation of myocardial fJ adrenoceptors, but also the activation of coronary IX-adrenoceptors can contribute to myocar dial ischemia. However, the role of fJ-adrenoceptor-mediated increases in contractility relative to heart rate in the initiation of ischemia is not clear, and the significance of IX-adrenoceptor mediated changes in coronary vasomotor tone, as well as the responsible IX-adrenoceptor subtypes are highly controversial. Malignant arrhythmias may be triggered by both IX- and fJ-adrenergic mechanisms. Current research in this field is focussed not only on the underlying physiological and pathophysiological mechanisms, but also on clinical treatment strategies, e. g., by fJ-blockade, IX-blockade, bradycardic agents and calcium antagonists. Recent findings were presented and future research directions discussed during the 61" International Titisee Conference, held at the Schwarzwald-Hotel, Titisee, March 29-31, 1990 under the sponsorship of the Boehringer Ingelheim Foundation. Dr. Hasso Schroeder and Dr. Hermann Frohlich deserve special thanks for their generous support and pleasant organization of the meeting. The publication of the proceedings has been made possible by grants from Astra Chemicals, Bayer, ICI, Dr. Karl Thomae, and Upjohn
Download or read book Adrenergic Mechanisms in Myocardial Ischemia written by Gerd Heusch and published by Springer Verlag. This book was released on 1991 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Factors Influencing Adrenergic Mechanisms in the Heart written by M. Szentiványi and published by Elsevier. This book was released on 2013-10-22 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physiological Sciences, Volume 27: Factors Influencing Adrenergic Mechanisms in the Heart is a collection of papers presented at the 1980 satellite symposium of the 28th International Congress of Physiological Science, held in Visegrád, Hungary. This symposium covered the achievements that modify the traditional views of adrenergic regulation of cardiac muscle and coronary blood vessels. This volume is composed 18 chapters and begins with a discussion of the effect of adrenaline on some aspects of electrical and mechanical activity in the frog heart. The subsequent chapters describe the heart rate changes in neurogenic hypertension, the developmental changes of the catecholamine-induced chronotropic responses related to the blood pressure responses, and the inverse reciprocal regulation of cardiac post-synaptic a- and b-adreneceptors by thyroid hormones. Other chapters deal with the mechanism of adenosine-induced inhibition of adrenergic neurotransmission in the ventricular myocardium; the comparative morphological studies of localized exogenous adenosine in heart muscle; adenosine sensitivity of canine coronaries; and the significance of nickel ion in the coronary vascular tone regulation. These chapters are followed by discussions of the physiological and pathological effects of beta modulator release and the histological study of experimental diabetic angiopathy. The last chapters examine some aspects of myocardial noradrenaline metabolism in the ischemic heart and the activity of alpha-adrenoceptor without employing beta blocking agents.
Download or read book Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction written by J. Brachmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new aspects on electrophysiological mechanisms and catecholaminergic contributions in the setting of acute and chronic myocardial ischemia. Special emphasis is placed on the full scope from basic molecular and cellular mechanisms to experimental models of close clinical proximity. A number of internationally distinguished scientists present their latest findings in this significant research area within the perimeter of cardiovascular disease which continues to lead mortality statistics in most industrialized countries. Contents of this book cover, in addition to other subjects, release and uptake of catecholamines in ischemia, regulation of receptors, adrenergic contribution to ventricular arrhythmias and mechanisms of ischemic malignant arrhythmias as well as underlying changes in membrane currents and the electrophysiological response to beta-adrenergic blocking drugs. In addition to original contributions, a number of editorial chapters are included for conclusions and future development in these areas.
Download or read book Adrenergic Mechanisms in Congestive Heart Failure Subsequent to Myocardial Infarction written by Rajat Sethi and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adrenergic Mechanisms in Cardiac Ischemic Responses and in the Action of Antianginal Drugs written by Henry L. Garvey and published by . This book was released on 1968 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book Myocardial Ischemia and Arrhythmia written by M. Zehender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents, in synoptic form, the latest and most comprehensive experimental and multi-faceted clinical findings on the potential arrythmogenic implications of acute myocardial ischemia. Together with a critical discussion of the related diagnostic and therapeutic consequences and outcomes, it presents a solid basis for efforts to reduce the occurance of sudden cardiac death in patients with coronary heart disease.
Download or read book Factors Influencing Adrenergic Mechanisms in the Heart written by Mátyás Szentiványi and published by . This book was released on 1981 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathophysiology and Rational Pharmacotherapy of Myocardial Ischemia written by G. Heusch and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ischemie heart disease is still the most frequent cause of death in the western world. There have been significant achievements in diagnostic procedures as well as in the medical, invasive, and surgiealtreatment ofischemieheart disease inrecent years. A variety ofdrugs are availablefor the pharmacotherapyofischemieheart disease, par ticularly nitrates, ß-blockers, and calcium-antagonists which are used as mono therapy or in various combinations. However, the selection of patients for a certain treatment, as weIl as the optimization of an individual treatment are still largely empirical. On the other hand, the recent advances in experimental cardiology emphasize the extremely complex and dynamie scenario of ischemic heart disease, involving endothelial damage, coagulation processes, metabolie and morphologie derangements, coronary constrictor mechanisms, blood flow redistribution, arrhythmogenesis, contraetile dysfunction during ischemia and reperfusion, and finally lack or presence of pain perception. Therefore, it appears desirable to close the gap between experimental and clinical cardiology and, thus, to provide a pathophysiologieal basis for rational cliniealdecisions with respect to diagnostic and therapeutic procedures. The idea for this book arose during the preparation of a seminar series on experi mental cardiology, when I found it diffieultto collect the pertinentinformation from textbooks of cardiology, physiology, pathology, and pharmacology, as well as from numerous review and original artieies on specifictopies. I am now very grateful that expert cliniealand experimental colleagues from around the world have joined me in the effort to provide a comprehensive textbook on the pathophysiology of myocar dial ischemia and its rational pharmacotherapy.
Download or read book Catecholamines and the Heart written by W. Delius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: An International Symposium "Catecholamines and the Heart" was held in Munich in May 1981, which was organized in cooperation with the Council on Cardiac Metabolism of the International Society and Federation of Cardiology and with the Microcirculation Working Group of the European Society of Cardiology. It was the aim of the organizers to evaluate in this Symposium the recent advances made in the field of sympathetic control of heart function. Particular attention was given to neural sympathetic pathways, to mechanisms and consequences of adrenoceptor stimulation and blockade as well as to clinically relevant implications mainly regarding the significance of catecholamines and of adrenoceptors in various heart diseases. The broad scope was covered in 34 papers presented by physiologists, pharmacologists and cardiologists during a two day meeting which was attended by an international audience. This book includes all papers as well as the discussions following each presentation. To accomplish rapid publication the manuscripts are published as submitted by the authors. The discussions were edited making use of the written questions and answers of the discussants. The Symposium was generously sponsored by Astra Chemicals GmbH, Wedell Holstein, Germany, which thus made possible a very fruitful exchange of information, ideas and concepts between specialists in various disciplines. The organizers gratefully acknowledge this support once again and would like to thank Dr. T. Kreuzer, the representative of Astra Chemicals, for his personal engagement.
Download or read book Myocardial Ischemia Mechanisms Reperfusion Protection written by Morris Karmazyn and published by Birkhäuser. This book was released on 2013-03-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
Download or read book Cardiac Adrenergic Mechanisms and Effects of Drugs on Coronary Flow and Heart Action written by Richard A. Gillis and published by . This book was released on 1965 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The search for drugs to relieve angina pectoris has been primarily a search for agents which enhance coronary flow without significantly increasing cardiac oxygen demand. Glyceryltrinitrate (nitroglycerin) has long been used clinically in angina pectoris and remains the standard by which the potency of other agents may be classified. The exact cause of the benefit derived from nitroglycerin in cardiac ischemic disease is far from clear. Usually it is attributed to improved myocardial oxygenation resulting from coronary dilatation and/or reduced peripheral resistance with a reduction in myocardial oxygen requirement. [...]" --
Download or read book Mechanisms of Local Noradrenaline Release in Acute Myocardial Ischemia written by Leif Carlsson and published by . This book was released on 1987 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adrenergic Mechanisms in Cardiac Pathophysiology written by Xiao-Ming Gao and published by . This book was released on 2003 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adrenergic Mechanisms in Cardiovascular Tissues written by Gary Scott Allen and published by . This book was released on 1973 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Brain Interactions written by Giuseppe Di Pasquale and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade there has been a growing interest in the study of the interactions between the heart and the brain, especially in the field of cerebral ischemia. The interactions between cardiovascular and cerebrovascular diseases are of relevance not only for research investigation, but also for clinical implications in the daily clinical practice. i.e. A wealth of information has been gathered particularly on three topics, cardiovascular consequences of cerebral injuries, cardioembolic stroke, and association of carotid and coronary artery disease. The available information, however, is still sparse and fragmentary mainly because of the lack of commun ication between neurologists and cardiologists. With the aim of improving communication between several disciplines and technologies, we started to organize since 1987 in Bologna, Italy, an international Symposium on heart brain interactions to be held every 3 years. Our intention was to gather prominent clinicians and researchers from outstanding cardiologic and neuro logic institutions actively involved in the study of heart-brain interactions. The ambitious goal has been to fit different pieces of information like in a puzzle. This book originates from the contributions presented at the 2nd Sympo sium which was held in Bologna on November 30-December 1, 1990. The book is subdivided into three sections: I cardiovascular consequences of cerebral damage, II cardiogenic cerebral ischemia, III cerebrovascular and coronary artery disease.