Download or read book Adjuvant Transarterial Chemoembolization After Radical Resection Contributed to the Outcomes of Hepatocellular Carcinoma Patients with High risk Factors written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transarterial chemoembolization for hepatocellular carcinoma patients written by and published by Frontiers Media SA. This book was released on 2024-04-09 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Download or read book Cutting edge Liver Surgery based Modalities for Diagnosis and Treatment of Liver Tumors written by Qizhao Huang and published by Frontiers Media SA. This book was released on 2023-09-06 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Targeted Therapies in Oncology Second Edition written by Giuseppe Giaccone and published by CRC Press. This book was released on 2013-10-21 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Download or read book Clinical Applications of Radiofrequency Ablation for Hepatocellular Carcinoma written by Kwok-Chai Kelvin Ng and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Clinical Applications of Radiofrequency Ablation for Hepatocellular Carcinoma" by Kwok-chai, Kelvin, Ng, 吳國際, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: ABSTRACT There is a wide range of applications of radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC). Despite its favorable reported survival results, RFA is associated with various unresolved problems. The objectives of the present study are to investigate the different aspects of clinical applications of RFA in the management of HCC patients. Retrospective analysis of prospectively collected database was performed to evaluate the research gaps of RFA for HCC. Because of the high tumor recurrence after RFA, the impact of tumor recurrence pattern on long-term patients' survival is of great importance for the clinician to optimize the treatment strategy. It has been shown that patients with local or same segment intrahepatic recurrence had better overall survival than those with different segment intrahepatic recurrence or extrahepatic metastasis. On multivariate analysis, the pattern of recurrence was the independent prognostic factor for overall survival after RFA. Effective treatment modalities were feasible in the majority of patients with local or same segment intrahepatic recurrence. Meanwhile, aggressive management approach in terms of preemptive liver transplantation may be necessary for patients with risk factors for the development of different segment recurrence. Safety and efficacy of RFA for perivascular HCC deserves in-depth investigation because of the well known "heat-sink" effect of intrahepatic blood flow and v the potential risk of portal vein thrombosis. Retrospective comparative study has shown no statistical difference between patients with and without perivascular HCC in treatment-related mortality and morbidity, complete ablation rate, local recurrence rate and overall survival rate. Open approach of RFA is the contributing factor for the safety and high efficacy of RFA for perivascular HCC. The comparisons of therapeutic effect between RFA and other treatment modalities for unresectable HCC and intrahepatic recurrence are poorly defined. For unresectable HCC, the present study has revealed a comparable survival outcome between RFA and transarterial chemoembolization (TACE) groups. More importantly, RFA was associated with more efficient tumor control than TACE, which was illustrated by the significantly longer median time to disease progression. For recurrent HCC, the short-term efficacy of RFA was shown to be comparable to that of hepatic re-resection, in terms of hospital mortality, complication rate, and the proportion of patients with residual tumor after treatment. However, RFA was associated with a higher tumor recurrence rate than hepatic re-resection. The novel use of RFA in the acute phase of ruptured HCC has never been reported. In fact, complete hemostasis could be achieved in all patients with RFA. In contrast, transarterial embolization (TAE) failed to control tumor bleeding in 13.4% of patients. As a salvage procedure, RFA has 100% successful rate in those patients who failed TAE. In addition, complete tumor ablation by RFA was achieved in 13.3% of vi patients. This reflects the unique of RFA in terms of achieving both hemostasis and tumor clearance. With the useful information concluded in this study, the management strategy of patients with HCC by RFA can be further refined and better survival outcome would be expected. vii DOI: 10.5353/th_b3955767

Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Download or read book Novel Therapeutic Approaches for Biliary Tract Cancer and Hepatocellular Carcinoma written by Daniel Neureiter and published by Frontiers Media SA. This book was released on 2023-11-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatobiliary cancers, encompassing biliary tract cancer (BTC) and hepatocellular carcinoma (HCC) are highly lethal. Biliary tract cancer is a deadly disease with a very low five-year survival rate. BTC is assumed to be the fifth most common gastrointestinal malignancy and can be categorized into extrahepatic cholangiocarcinoma (EHC), intrahepatic cholangiocarcinoma (IHC) and gallbladder cancer (GBC), based on the anatomic location. Patients suffering from BTC can be currently treated with radiation therapy, palliative or with a combination of two chemotherapeutics, cisplatin and gemcitabine. Hepatocellular carcinoma is the most prevalent form of liver cancers and was responsible for over 830,000 deaths related to cancer worldwide in 2020. HCC is therefore the second most leading cause of cancer deaths globally. Current treatment options encompass targeted therapy with sorafenib, immunotherapy and post-surgery adjuvant chemotherapy. Factors that might contribute to these dismal outcomes are diagnosis at an already late stage, due to unspecific symptoms, limited therapeutic options, lack of targets and understanding of molecular processes during carcinogenesis as well as resistance to current chemotherapy/treatment. Therefore, these current issues need to be further addressed and solutions and alternative approaches must be provided in order to detect these illnesses at an early stage, prolong the survival time of patients suffering from HCC and BTC and overcome general resistance to available treatment options. The aim of this research topic is to provide an overview about mechanisms of therapy resistance, the identification of therapeutic relevant targets and finally, innovative and alternative approaches for treating BTC and HCC successfully.

Download or read book Radiology of the Post Surgical Abdomen written by John Brittenden and published by Springer Science & Business Media. This book was released on 2012-03-28 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive description of the most common abdominal operations involving the gastrointestinal tract, pancreas, liver and genitourinary systems, illustrated with artists' drawings and images of normal post operative anatomy. The complications associated with each procedure will be in table format consisting of text alongside imaging examples. There will also be teaching points included. The book will be divided into nine chapters.

Download or read book Hepato Pancreato Biliary and Transplant Surgery written by Quyen D Chu and published by Beaux Books Publishing, LLC. This book was released on 2018-01-08 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.

Download or read book Liver Malignancies written by C. Bartolozzi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver malignancies. Following background chapters on anatomy, epidemiology, and clinicopathologic features, each of the diagnostic imaging techniques is carefully appraised, focusing on new developments in equipment and contrast agents. The interventional therapeutic approaches to primary and secondary hepatic malignancies are then discussed in depth, as well as such special topics as liver tumors in children and hepatic transplantation. Written by leading experts from around the world, this will prove to be an indispensable source of information for both clinicians and researchers.

Download or read book Novel Insights into the Treatment of HCC and Liver Tumors written by Alessandro Vitale and published by Frontiers Media SA. This book was released on 2022-05-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Radiofrequency Ablation for Small Hepatocellular Carcinoma written by Minshan Chen and published by Springer. This book was released on 2015-11-26 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive guide to the treatment of small hepatocellular carcinoma (sHCC) using a minimally invasive technique: radiofrequency ablation (RFA). RFA has emerged as a new treatment modality and become the main modality of locoregional therapy. Extensive clinical research indicates that RFA is as effective as surgical resection for sHCC, and it has the advantage of being less invasive. However, the outcomes after RFA are largely dependent on the operators’ experience- known as the “learning curve”. This book presents the characteristics of sHCC and discusses why sHCC is the best candidate for RFA. Then it introduces all the commercially available RFA systems, and their working principles, advantages, disadvantages and so on. It goes on to demonstrate how to perform RFA under the guidance of ultrasound, CT, laparoscopy, or during open operation. Finally, it discusses the radiologic assessment and follow‐up after RFA, as well as adjuvant therapies and clinical trials on RFA. The authors are experts from the fields of pathology, radiology, surgery, and gastroenterology, as well as manufacturers. With this book, readers gain have a clear idea of when and how to do RFA. It aims to standardize and generalize the procedure of RFA, which will be very helpful in improving the outcome of RFA for sHCC.

Download or read book Carbon Ion Radiotherapy written by Hirohiko Tsujii and published by Springer Science & Business Media. This book was released on 2013-12-25 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Download or read book Oxford Textbook of Fundamentals of Surgery written by William E. G. Thomas and published by Oxford University Press. This book was released on 2016 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.

Download or read book Interventions in Oncology written by Charles E. Ray and published by Lippincott Williams & Wilkins. This book was released on 2004-06-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventions in Oncology, the latest in the Society of Interventional Radiology (SIR) Syllabus Series, is a state-of-the-art textbook on radiologically guided diagnosis and minimally invasive treatment options in patients with cancer. The text includes imaging strategies and discussions of treatment options including chemotherapy, embolization, radiofrequency ablation, brachytherapy, and gene therapy. Special emphasis is given to hepatic malignancies and their interventional radiologic treatment options.

Download or read book Liver Cancers written by Tim Cross and published by Springer. This book was released on 2018-12-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery