Download or read book Adenosine Receptors in the Nervous System written by J. A. Ribeiro and published by Taylor & Francis Group. This book was released on 1989 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: A satellite Symposium on Adenosine Receptors in the Nervous System was held in April 1989 in Portugal. This book contains the manuscripts of the papers presented by the participants, who were from Europe, America and Asia.
Download or read book Adenosine Receptors in Health and Disease written by Constance N. Wilson and published by Springer Science & Business Media. This book was released on 2009-07-28 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
Download or read book Adenosine in the Nervous System written by Richard E. Stone and published by Academic Press. This book was released on 2012-12-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacology and clinical therapeutic potential of adenosine and its analogues in the nervous system. Among the topics covered are adenosine transport in nervous systemtissues, adenosine production and metabolism and the electropharmacology of adenosine.
Download or read book Adenosine Receptors in Neurodegenerative Diseases written by David Blum and published by Academic Press. This book was released on 2017-03-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.
Download or read book A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics written by Pier Andrea Borea and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make “A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics” an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3).
Download or read book Adenosine Receptors and Parkinson s Disease written by Hiroshi Kase and published by Academic Press. This book was released on 1999-10-15 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease. Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function Proposes a hypothesis of adenosine A2A receptor function in the striatum Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints
Download or read book The Adenosine Receptors written by Pier Andrea Borea and published by Humana Press. This book was released on 2018-07-28 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Download or read book The Role of Adenosine in the Nervous System written by Yasuhiro Okada and published by Elsevier Science & Technology. This book was released on 1997 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. On the basis of significant advances in the molecular, cellular and behavioural fields in the past decade, there has been a great increase in our knowledge of the biological action of adenosine and its related compounds in the nervous system.These proceedings survey the expansion of ideas and development of potential applications and bring together the up-to-date knowledge and in-depth understanding of adenosine, a highly significant neuromodulator. The objectives of the symposium were not encyclopedic, but rather catalytic. Various fields of research from molecular biology to clinical therapeutics including several topics on the extraneuronal action of adenosine are covered.
Download or read book Pharmacological Sciences Perspectives for Research and Therapy in the Late 1990s written by A. Claudio Cuello and published by Birkhäuser. This book was released on 2012-12-06 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we pursued was to produce a volume of reasonable size which would feature all of the plenary lectures and symposia from those authors who agreed to participate. To this end, we solicited mini reviews from plenary lecturers and asked symposia organizers to coordi nate a single short-review covering the individual topics within their event. Those who accepted this challenge are evident in this volume. We express our gratitude to these authors for doing so, and for exercising considerable ingenuity in completing their task within a reasonable time.
Download or read book Adenosine Receptors written by Gyorgy Hasko and published by CRC Press. This book was released on 2006-07-20 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the deve
Download or read book Adenosine written by Susan Masino and published by Springer Science & Business Media. This book was released on 2012-08-30 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Download or read book Experimental Neurochemistry written by Abel Lajtha and published by Springer. This book was released on 1982-12-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.
Download or read book Caffeine written by P. B. Dews and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Before the late 1970s, interest in caffeine among both the general public and the scientific community was at a relatively low level for many years, even though it was recognized that caffeine was an al most universal component of the diet. The National Coffee Associa tion was supporting a continuing program of research, some re search was being conducted by a few of the largest companies selling coffee, and an occasional university researcher became inter ested in caffeine and conducted experiments, often on effects of caf feine in very high concentration in vitro on skeletal muscle fibres or on dividing cells. Since 1978, however, there has been a mighty up surge in both public and scientific interest in caffeine. It is interest ing to note that this was prompted not by discovery of hitherto un known effects or hazards of caffeine, but by the actions of a regulatory agency, the Food & Drug Administration (FDA) of the U. S. Public Health Service. The U. S. Congress passed new laws on foods and drugs in 1958. One of the provisions was for testing of food additives to assess risk to health. As it was clearly impracticable to require immediate test ing of all additives already in use, a list was drawn up of some hun dreds of additives that were generally recognized as safe (GRAS).
Download or read book Adenosine Receptors in Neurology and Psychiatry written by and published by Academic Press. This book was released on 2014-08-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas. Expertise of contributors Subject including practical drug development from basic science, as translational research taste Structure of contents focusing on two CNS areas for diseases (neurology and psychiatry)
Download or read book Limits of Human Endurance written by Luc J. C. van Loon and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to improve exercise performance capacity through adequate nutrition Nutrition is one of the key factors that modulate exercise performance. In this book, a group of expert scientists discuss the ergogenic properties of various nutritional interventions and present research to show that dietary strategies can be applied to extend the limits of human endurance, lower the risk of illness or injury, and speed recovery rates. More specifically, they discuss recent findings on topics such as caffeine and its effect on the brain, carnitine and fat oxidation, ergogenic properties of beta- alanine, dietary protein and muscle reconditioning, nutrition and immune status, and the importance of proper hydration. This publication will provide the reader with many novel insights into the complex interaction between nutrition and exercise, allowing them to define more effective dietary strategies to improve health and performance. Moreover, while focusing on elite athletes, it is interesting to note that some of the discoveries can be applied beyond this niche, for example to improve performance outcomes in the elderly.
Download or read book Adenosine Receptors in Neurodegenerative Diseases written by David Blum and published by Academic Press. This book was released on 2017-03-10 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions
