Download or read book Adenosine and Adenine Nucleotides As Regulators of Cellular Function written by John W. Phillis and published by CRC Press. This book was released on 1991-06-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport, and receptors for endogenous adenosine and the adenosine triphosphate; functions of purines at the cellular level; the role of adenosine in the regulation of flow in different vascular beds; and angiogenesis. The book also addresses the purinergic regulation of the cardiac, renal, gastro-intestinal, and central nervous system, as well as potential therapeutic avenues for purine use. The book will be valuable to physiologists, pharmacologists, and other basic and clinical scientists interested in updating their knowledge of the expanding biological roles of these substances.
Download or read book Adenosine and Adenine Nucleotides From Molecular Biology to Integrative Physiology written by Luiz Belardinelli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology covers a wide range of subjects from molecular and cellular biology to clinical applications. A great emphasis has been placed on cutting edge information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research. The book also includes information on potentially promising developments in the therapeutic applications of adenosine related drugs and ATP. The tradition of past meetings is also maintained by including in the program presentations of new research in the areas of purine metabolism and physiology, and pharmacology of adenosine and adenine nucleotides. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology is an excellent, up-to-date reference book for basic and clinical scientists in the field of adenosine and adenine nucleotides.
Download or read book Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides written by Hans P. Baer and published by New York : Raven Press. This book was released on 1979 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides written by and published by . This book was released on 1979* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Role of Adenosine and Adenine Nucleotides in the Biological System written by Shōichi Imai and published by Elsevier Publishing Company. This book was released on 1991 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad view of the current research activities in adenosine and adenine nucleotide research, with contributions from many leading experts in the field. Like the three previous Symposia, the 4th International Symposium on Adenosine was designed to integrate the recent advances made in the rapidly expanding field of adenosine research by various biological and medical disciplines. Over 70 presentations were made, with over 60 posters displayed, and all the papers presented by the invited speakers and related discussions, as originally submitted by the authors are contained in this proceedings. This comprehensive text covers all important aspects of the subject and is a must for any scientist with an interest in adenosine research.
Download or read book Regulatory Function of Adenosine written by Robert M Berne and published by . This book was released on 1983-04-30 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purines in Cellular Signaling written by Kenneth A. Jacobson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on purine derivatives as potent and selective modulators of physiologic functions has moved to center stage. This volume covers the biology and chemistry of purines and of their receptors broadly under these section headings: - Adenosine Receptors and Effector Systems - Adenine Nucleotide Receptors and Effector Systems - Phosphodiesterase Enzymes and Inhibitors The presentations focus on the potential development of clinically useful drugs and powerful agents that activate or block purinergic receptors or that inhibit phosphodiesterases. Xanthines (caffeine and theophylline) represent one class of such agents. This volume is for pharmacologists, biochemists, and medical chemists in research labs of universities, gov- ernment, and the pharmaceutical industry.
Download or read book Regulatory Function of Adenosine written by Robert M. Berne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978, the "International Conference on Physiological and Regulatory Funetions of Adenosine and Adenine Nueleotides," held in Banff, Canada, served as an effective catalyst in enabling scientists with differ ent points of view to exchange information and ideas on this subject. Since 1978, the amount of research on different as peets of adenosine metabolism, mechanism of action, transport, and function in various tissues (in both nor maI and abnormal states) has increased exponentially, and there was an urgent need for another meeting for updating information on this burgeoning subject. The focus of the meeting was extremely sharp, but the scope of the subject material was very broad. Scientists categorized as chemists, biochemists, physiologists, pharmacologists, and immunologists, working with cells and eelI fragments, with tissues such as heart, brain, musele, fat, kidney, and with human beings having immune deficiency diseases participated in the sym posium. They had an opportunity to air their differences, reinforce their areas of agreement, and, most important, they educated each other with respeet to research on adenosine; it is hoped that they also enriched their own research programs from the information they gained from their fellow participants.
Download or read book Adenosine written by V. Stefanovich and published by Oxford University Press, USA. This book was released on 1985 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book thoroughly reviews research on adenosine and offers new ideas and information concerning the role and function of adenosine in mammalian systems.
Download or read book Extracellular ATP and adenosine as regulators of endothelial cell function written by Evgenia Gerasimovskaya and published by Springer Science & Business Media. This book was released on 2010-04-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
Download or read book Methods Used in Adenosine Research written by David Paton and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine. Another thirty years were to pass before the possible physiological role of adenosine in coronary vasodilation was studied by Berne and others. Since then, there has been a tremendous increase in research into the actions of adenosine. Workers from many disciplines have employed a wide variety of techniques, since adenosine is a product of and a substrate for a number of metabolic pathways, is transported into cells, and acts at discrete receptor sites to modulate the activity of adenylate cyclase and to produce important actions on many cells and tissues including platelets, adipo cytes, heart, blood vessels, and other smooth muscles. International symposia on the actions of adenosine were held in 1978, 1981, and 1982, and the proceedings of these symposia have been published (Baer and Drummond, 1979; Daly et at., 1983; Berne et at., 1983). Since it is not the primary purpose of the present volume to review our current understanding of the nu merous actions of adenosine, these volumes should be consulted for such details. Rather, the present volume has been planned to provide both graduate students and investigators in pharmacology and related disciplines with a summary of some of the methods now available for the study of the actions of adenosine and, in particular, to highlight their possible uses and limitations.
Download or read book Purine Metabolism in Man III written by A. Rapado and published by Springer. This book was released on 1980-09 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: However, there have been many new developments during the last three years and the scope of the communications reflects not only increasing depth of knowledge, but also a widening of the field. This publication has clinical and fundamental implications for internal medicine, pediatrics, urology, biochemistry, immunology, genetics, and oncology. It is interesting to compare the scope of this volume with that of its predecessors. The main emphasis has shifted from the study of gout and the dissection of metabolic pathways to encompass investigations in the fields of oncology, immunology, and lymphocyte physiology. There are pointers to possible implications in relation to cardiology and neuromuscular diseases, which may well prove to be growing points for the future. In spite of considerable work on the mechanism of urinary stone formation, the inter-relationship between uric acid and calcium oxalate urolithiasis remains obscure.
Download or read book Adenosine and Adenine Nucleotides written by David Murray Paton and published by Taylor & Francis Group. This book was released on 1988 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction written by Papa and published by Birkhäuser. This book was released on 2012-03-23 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenine Nucleotides play a major role in cellular metabolism and functions, serving as high-potential phosphate transfer compounds in energy metabolism and as substrates and co-factors for proteins involved in signal transduction. During the last few years definite advancement has been made in elucidating the molecular and genetic aspects of the enzyme involved in oxidative phosphorylation, the so-called FoFl H~-ATP synthase. Non-invasive NMR technologies have been developed to monitor in vivo the energy level of tissues based on determination of the concentrations of adenine nucleotides, phosphate and phosphate esters. Thus it became clear that the capacity of oxidative phosphorylation adapts itself to the ATP demand which changes continuously with the physiological state in various tissues. This is achieved by regulation of the enzyme activity as well as by regulation of its biogenesis. The reversible phosphorylation of proteins is re cognised as a major regulatory mechanism in eukaryotic as well as in prokaryotic cells for cellular signal transduction and control of gene expression, cell growth, differentation and oncogenesis. The same applies to the role played by cAMP. A further topic of growing interest concerns the discovery of the ATP binding cassette (ABC) superfamily of transport proteins which includes systems of primary importance in medicine such as the multi-drug resistance P glycoprotein, the cystic fibrosis transmembrane conductance regulator (CFTR) and the 70 kd peroxisomal membrane protein. Finally, much attention is being devoted in many laboratories to the molecular structure and role of ATP modulated channels.
Download or read book Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction written by Papa and published by Birkhäuser. This book was released on 1992-07-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenine Nucleotides play a major role in cellular metabolism and functions, serving as high-potential phosphate transfer compounds in energy metabolism and as substrates and co-factors for proteins involved in signal transduction. During the last few years definite advancement has been made in elucidating the molecular and genetic aspects of the enzyme involved in oxidative phosphorylation, the so-called FoFl H -ATP synthase. Non-invasive NMR technologies have been developed to monitor in vivo the energy level of tissues based on determination of the concentrations of adenine nucleotides, phosphate and phosphate esters. Thus it became clear that the capacity of oxidative phosphorylation adapts itself to the ATP demand which changes continuously with the physiological state in various tissues. This is achieved by regulation of the enzyme activity as well as by regulation of its biogenesis. The reversible phosphorylation of proteins is re cognised as a major regulatory mechanism in eukaryotic as well as in prokaryotic cells for cellular signal transduction and control of gene expression, cell growth, differentation and oncogenesis. The same applies to the role played by cAMP. A further topic of growing interest concerns the discovery of the ATP binding cassette (ABC) superfamily of transport proteins which includes systems of primary importance in medicine such as the multi-drug resistance P glycoprotein, the cystic fibrosis transmembrane conductance regulator (CFTR) and the 70 kd peroxisomal membrane protein. Finally, much attention is being devoted in many laboratories to the molecular structure and role of ATP modulated channels."
Download or read book Regulation of Adenosine Kinase and Adenosine Release from Endothelial Cells written by Kwan-Ki Hwang and published by . This book was released on 1999 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
