Download or read book Acute beta 1 Blockade Slows Cardiorespiratory Kinetics and Increases Oxygen Extraction at Onset of Moderate Intensity Exercise in Healthy Women written by Christine Bowlus and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: PURPOSE: Cardio-selective [beta]-blockade slows pulmonary oxygen uptake kinetics (V̇O2) at exercise onset; however the contribution of heart rate (HR) and the corresponding impact on active muscle deoxygenation kinetics have not been characterized. The purpose of this study was to determine if [beta]1-blockade slows V̇O2 kinetics and underlying cardiovascular and active muscle deoxygenation responses during moderate intensity exercise in healthy younger women. METHODS: Thirteen healthy women (age 21-32) were tested on a recumbent cycle ergometer during square wave cycling transitions from 20 watts to 85% of estimated lactate threshold (81.0±20.7 W) with an intravenous infusion of saline or the fast-acting [beta]1-selective antagonist esmolol in randomized order, separated by 45 minutes. Breath-by-breath V̇O2 was measured by indirect calorimetry, vastus lateralis deoxygenation (HHb) was measured by near infrared spectroscopy, and heart rate (HR) was measured with EKG. Phase 2 V̇O2, HHb, and HR data were modeled with single exponential functions. Speed of kinetics were measured by the time constant [tau], the time taken to reach 63% of steady-state. Comparisons were made using paired t-tests and correlations were tested using Pearson's coefficient. RESULTS: Esmolol infusion increased the pulmonary V̇O2[tau] (24.9±6.3 vs. 37.3±11.9 sec, p=0.002), decreased HR amplitude (31±8 bpm vs 26±6, p=0.010), increased amplitude of HHb (1.97±1.82 AU vs. 2.34±2.12, p=0.029) and decreased HHb calculated time delay (12.3±4.4 s vs. 8.1±2.7 s, p=0.026). CONCLUSIONS: Acute [beta]1-blockade slows pulmonary V̇O2 kinetics, decreases steady-state heart rate and evokes a larger increase in active muscle oxygen extraction during the onset of moderate intensity leg exercise in young women. These findings suggest that in healthy women, an acute reduction in oxygen delivery is buffered by a rapid onset in active muscle deoxygenation and increased oxygen extraction.
Download or read book Oxygen Uptake Kinetics in Sport Exercise and Medicine written by Andrew M. Jones and published by Routledge. This book was released on 2013-07-04 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite its crucial importance, scientists interested in the limitations of human physical performance have only just started to give the field of oxygen uptake kinetics the attention it deserves. Understanding the principal determinant of the oxygen uptake kinetics is fundamental to improving human performance or the quality of life. This book provides a detailed overview of the current state of knowledge of this emerging field of study, and features: * an introduction to oxygen uptake kinetics and historical development of the discipline * measurement and analysis of oxygen uptake kinetics * control of and limitations to oxygen uptake kinetics * applications of oxygen uptake kinetics in a range of human populations. Oxygen Uptake Kinetics in Sport, Health and Medicine is richly illustrated and structured to enable easy access of information and represents an invaluable resource for students and researchers in exercise physiology, as well as for respiratory physiologists and pulmonary clinicians.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1978 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Respiratory Physiology written by John Burnard West and published by . This book was released on 1996 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present-day respiratory physiology stems largely from the explosion of ideas which took place during and after World War II. A number of the major players are still active, but the opportunity to prepare a personal history of this branch of medicine will soon be lost. In a sense then, this book offers an exceptional, even unique, opportunity. We are offered a first-hand chronicle of the advancements made in respiratory physiology in the course of this century by one of the principal figures in the field. The volume covers every aspect of the evolution of this important area of knowledge: morphology, gas exchange and blood flow, mechanics, control of ventillation, and comparative physiology. Some of the chapters are personal accounts of the development of respiratory physiology as observed by the author. It is hoped that what is lost in objectivity by this approach is more than made up by the captivating insights provided by the author into the process of scientific research and discovery.
Download or read book Energetics of Muscular Exercise written by Guido Ferretti and published by Springer. This book was released on 2015-03-25 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the maximal power and capacity of the three major biochemical pathways - aerobic (oxygen consumption), anaerobic lactic (muscle lactate accumulation in absence of oxygen consumption), and anaerobic alactic (phosphocreatine hydrolysis) metabolism - as well as the factors that limit them. It also discusses the metabolic and cardio-pulmonary mechanisms of the dynamic response to exercise. The way and extent to which the power and capacity of the three major energy metabolisms are affected under a number of different conditions, such as training, hypoxia and microgravity, are also described.
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book Cardiovascular Prevention and Rehabilitation written by Joep Perk and published by Springer Science & Business Media. This book was released on 2007-09-18 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this textbook is to give guidance in prevention, lifestyle counselling and rehabilitation for cardiologists, other physicians and many different categories of health professionals in cardiac rehabilitation teams.
Download or read book IOC Manual of Sports Cardiology written by Mathew G. Wilson and published by John Wiley & Sons. This book was released on 2016-12-19 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 8 Cardiovascular Screening for the Prevention of Sudden Cardiac Death in AthletesIntroduction; The Risk of Sudden Death in Athletes; Rationale for Screening Competitive Athletes; The Screening Programmes Implemented in Italy; Rationale for Including a 12-Lead ECG in the PPE ; Efficacy of Screening to Identify Cardiac Disease Risk; Impact of the Screening Programme on Cardiac Mortality; Costs of Systematic Screening across Italy; Limitations of Screening Programmes; Conclusion; References
Download or read book Niosh Criteria for a Recommended Standard Occupational Exposure to Heat and Hot Environments written by National Institute for Occupational Safety and Health (U.S.) and published by National Institute on Drug Abuse. This book was released on 2018-08-03 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Occupational exposure to heat can result in injuries, disease, reduced productivity, and death. To address this hazard, the National Institute for Occupational Safety and Health (NIOSH) has evaluated the scientific data on heat stress and hot environments and has updated the Criteria for a Recommended Standard: Occupational Exposure to Hot Environments [NIOSH 1986a]. This updated guidance includes information about physiological changes that result from heat stress, and relevant studies such as those on caffeine use, evidence to redefine heat stroke, and more. Related products: Weather & Climate collection is available here: https://bookstore.gpo.gov/catalog/weather-climate Emergency Management & First Responders can be found here: https://bookstore.gpo.gov/catalog/emergency-management-first-responders Fire Management collection is available here: https://bookstore.gpo.gov/catalog/fire-management
Download or read book Continuous Renal Replacement Therapy written by John A. Kellum and published by Oxford University Press. This book was released on 2016 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.
Download or read book Tolerable upper intake levels for vitamins and minerals written by European Commission. Scientific Committee on Food and published by . This book was released on 2006 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nunn s Applied Respiratory Physiology written by John F. Nunn and published by Butterworth-Heinemann. This book was released on 1993-10-04 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nunn's Applied Respiratory Physiology.
Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Download or read book Cardiopulmonary Exercise Testing and Cardiovascular Health written by Karlman Wasserman and published by Wiley-Blackwell. This book was released on 2002-05-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiopulmonary Exercise Testing and Cardiovascular Health describes new research and findings relevant to cardiovascular health as assessed by cardiopulmonary exercise testing. It brings together investigational cardiologists, pulmonologists and scientists who share a wealth of experience needed to judge the cardiovascular health, and the impairments of patients with a variety of illnesses. It presents the latest applications of cardiopulmonary exercise testing, including the use of computers and rapidly responding gas analysers, which make it possible to evaluate the cardiovascular system in a quantitative way. This book provides a comprehensive, updated presentation of the information that can be gained by cardiopulmonary exercise testing to assess the health of the cardiovascular system as a whole, and its individual components. It heralds a new era in which the instrumentation provides accurate measurements and the functions of the heart, pulmonary, and peripheral circulations and the lungs can be described quantitatively in graphical form. This enables the physician and investigator to measure the degree of success with which the cardiovascular system supports the O2 supply for the energy-generating mechanisms needed to sustain life.
