Download or read book Acid Deoxyribonuclease DNase II in Rat Liver Cell Nuclei Isolated in the Presence of Ca written by K. F. Swingle and published by . This book was released on 1963 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: The failure of many investigators to find more than traces of deoxyribonuclease activity in the nuclei of cells has led to difficulties in attempting to ascribe a physiological role to this enzyme in living cells. Reinvestigation in this laboratory disclosed that nuclear fractions centrifugally separated from rat liver homoge nates in isotonic sucrose or in water, containing in each case 1.8 x 10 to the -3 power M CaCl(2) and washed repeatedly in the same media, retained a considerable amount of acid DNase activity. Similarly prepared nuclear fractions using calcium-free media lost nearly all of their DNase activity. This retention of activity in the presence of calcium was shown to be neither co-sedimentation of unbroken cells or of lysosomes with the nuclear fraction nor precipi tation of soluble e in the presence of calcium. The nuclear-bound enzyme was active under conditions which were shown not to remove it from the nuclei. (Author).

Download or read book U S Government Research Reports written by and published by . This book was released on 1964 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reports Received by Division of Technical Information Extension written by U.S. Atomic Energy Commission. Division of Technical Information and published by . This book was released on with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Journal of Histochemistry and Cytochemistry written by and published by . This book was released on 1964 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pathways for Cytolysis written by Gillian M. Griffiths and published by Springer. This book was released on 2011-12-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Apoptosis and Beyond written by James A. Radosevich and published by John Wiley & Sons. This book was released on 2018-09-18 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Download or read book Bibliography of Scientific and Industrial Reports written by and published by . This book was released on 1964 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bibliography of Agriculture written by and published by . This book was released on 1973 with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nucleic Acids Abstracts written by and published by . This book was released on 1979 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics Abstracts written by and published by . This book was released on 1979 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book INIS Atomindeks written by and published by . This book was released on 1981 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Federation Proceedings written by and published by . This book was released on 1976 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1984 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biochemistry Abstracts written by and published by . This book was released on 1980 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Dna Polymerases Biology Medicine And Biotechnology written by Giovanni Maga and published by World Scientific. This book was released on 2017-11-10 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.

Download or read book NETosis written by Geeta Rai and published by Academic Press. This book was released on 2019-06-01 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: NETosis: Immunity, Pathogenesis and Therapeutics takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present therapeutic approaches for dysregulated NETosis. Since Brinkamm, et al, discovered an unrecognized neutrophil anti-microbial mechanism responsible for the extracellular killing of invading pathogens in 2004, the novel process in which nuclear chromatin de-condenses and DNA is ejected into the extra cellular environment, trapping and inactivating tissue pathogens has rapidly evolved. - Presents an up-to-date and detailed analysis of NETosis - Brings together critical findings on NETosis as a comparatively novel immune mechanism - Focuses on the clinical aspects of NETosis that lead to drug development - Covers the topic with a cogency and passion that is based on years of scientific research