Download or read book Accommodation in ABO incompatible Kidney Transplantation written by Kota Takahashi and published by . This book was released on 2004 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most people today, ABO-incompatible kidney transplantation still carries the image of pronounced hyperacute rejection. However, with modern immunosuppressive therapy, hyperacute rejection will not occur within the first 24 hours. Clinical statistics in Japan show 3 cases of hyperacute rejection, but all of these occurred because the recipient was mistakenly transfused during surgery with frozen plasma of the same blood type. Delayed hyperacute rejection, occurring after the first 24 hours, is most likely to develop within 1 week post transplant. It does not manifest suddenly, but several years after transplantation. This means that humoral rejection ceases to occur after accommodation has been established. The use of evidence-based medicine to correct misconceptions in this area has proven to be meaningful. The publication of these data has made it possible to break down fixed thinking and prejudices previously regarded as fact in relation to ABO-incompatible kidney transplantation. It is believed that this will prove to be a major contribution in the future development of immunology. As these data are provided as a common resource for physicians performing transplantation procedures, it has encouraged more widespread implementation of organ transplantation.
Download or read book ABO incompatible Kidney Transplantation written by Kōta Takahashi and published by . This book was released on 2001 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABO incompatible kidney transplantation is indicated for patients for whom no ABO-identical or minor mismatch donor is available. Since the author and his colleagues performed the first ABO-incompatible kidney transplantation in Japan in 1989, 400 such transplantations have been performed in 41 hospitals in Japan and this practice has contributed to a number of new developments. One is a clearer and more suitable model for conceptualising the mechanism of humoral immune response which enables identification of antigens and antibodies and a therapeutic strategy against rejection. The rejection mechanisms are discussed not only from the perspective of immunology but also viewed from different angles, including anatomy, microscopic and macroscopic pathology, molecular biology and haematology. Immunosuppressive therapy is discussed, divided in four categories: extracorporeal immunomodulation with removal of humoral antibodies; drug therapy to suppress cellular immunity; splenectomy; and anticoagulation therapy. Surgical procedures for kidney transplantation and splenectomy are treated, including discussion of the best timing for the latter. The book gives an overview of the current status with statistics and results of questionnaires and ends with discussions of 17 case histories.
Download or read book ABO Incompatible Kidney Transplantation written by Kota Takahashi and published by Elsevier. This book was released on 2008-07-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Understanding the Complexities of Kidney Transplantation written by Jorge Ortiz and published by BoD – Books on Demand. This book was released on 2011-09-06 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney transplantation is a complex field that incorporates several different specialties to manage the transplant patient. This book was created because of the importance of kidney transplantation. This volume focuses on the complexities of the transplant patient. In particular, there is a focus on the comorbidities and special considerations for a transplant patient and how they affect kidney transplant outcomes. Contributors to this book are from all over the world and are experts in their individual fields. They were all individually approached to add a chapter to this book and with their efforts this book was formed. Understanding the Complexities of Kidney Transplantation gives the reader an excellent foundation to build upon to truly understand kidney transplantation.
Download or read book ABO incompatible Organ Transplantation from Japan written by Nihon Ishoku Gakkai. Meeting and published by Elsevier Publishing Company. This book was released on 2006 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the great success of Accommodation in ABO-incompatible Kidney Transplantation published in September 2004, Elsevier is proud to present the publication of ABO-incompatible Organ Transplantation from Japan, also edited by Professor Kota Takahashi. This new publication consists of a collection of invited papers from the International Meeting at the 41st Annual Meeting of the Japan Society for Transplantation held in Niigata on 29 October 2005. Since the donation of cadaver organs is extremely rare in Japan, ironically, ABO-incompatible transplants and partial liver transplants from living donors have become prevalent as a way of expanding the accommodation of transplants. More than 700 ABO-incompatible kidney transplants and over 300 ABO- incompatible liver transplants have been performed in Japan, and the results improve yearly.
Download or read book ABO incompatible Organ Transplantation written by Yi Wang and published by . This book was released on 2019 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the clinical application of ABO-incompatible transplantation. In the first part, it starts with the history, blood group antigen, antibody associated with ABO blood type, pathophysiology and pathology and related knowledge. In the second part, it covers clinical experience sharing of ABO-incompatible of heart, liver, lung and kidney transplantation. It provides a systematic methodologies and protocols. .
Download or read book Silva s Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Download or read book Frontiers in Transplantology written by Hesham Abdeldayem and published by BoD – Books on Demand. This book was released on 2016-09-07 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.
Download or read book Current Issues and Future Direction in Kidney Transplantation written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2013-02-13 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.
Download or read book ABO incompatible Organ Transplantation written by Yi Wang and published by Springer. This book was released on 2019-02-18 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the clinical application of ABO-incompatible transplantation. In the first part, it starts with the history, blood group antigen, antibody associated with ABO blood type, pathophysiology and pathology and related knowledge. In the second part, it covers clinical experience sharing of ABO-incompatible of heart, liver, lung and kidney transplantation. It provides a systematic methodologies and protocols.
Download or read book Renal Transplantation written by Nicholas Torpey and published by Oxford University Press, USA. This book was released on 2010-01-21 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a practical, comprehensive guide to aspects of renal transplantation. Every phase of donor and recipient care, from assessment to the transplant operation to post-transplant management, is included with chapters covering essential background information and up-to-date management guidelines.
Download or read book Hepato Pancreato Biliary and Transplant Surgery written by Quyen D Chu and published by Beaux Books Publishing, LLC. This book was released on 2018-01-08 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.
Download or read book Inflammation 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Download or read book Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of AnABO incompatible Renal Transplant written by Katherine Dominy and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction: Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet with adequate immunosuppressive treatment, this seldom leads to antibody-mediated rejection. Previous work using RNA sequencing compared ABO-incompatible (ABOi) and ABO-compatible (ABOc) surveillance biopsies with normal histology and identified a number of differentially expressed genes. Here we validate CYP4F11 as a marker of accommodation in an independent set of biopsies.Methods: RNA was obtained from formalin fixed paraffin embedded tissue from 20 ABOc and 9 ABOi renal transplant patients. Eighteen genes considered the top hits in sequencing analysis were assayed using a Nanostring nCounter custom panel. Results: Comparison between two groups confirmed a reduced expression of CYP4F11 in ABOi patients compared to ABOc (p=0.0005, Mann-Whitney test) (See figure). None of the other genes demonstrated a significant differential expression between the two groups. Discussion:Expression of CYP4F11 is reduced in ABOi patients confirming association with accommodation of the renal allograft. The study may be under-powered to validate any of the other genes. Most of the substrates of cytochrome p450 4F isoforms are eicosanoids, which play important roles in the inflammatory response. Cytochrome 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). CYP4F11 is known to have high expression in the kidney and 20-HETE inhibitors have demonstrated improved renal microvascular function in hypertension. The down-regulation of CYP4F11 in ABOi transplants may be likewise protecting the microvasculature.
Download or read book Clinical Xenotransplantation written by David K. C. Cooper and published by Springer Nature. This book was released on 2020-09-08 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
Download or read book Oxford Handbook of Dialysis written by Jeremy Levy and published by Oxford University Press, USA. This book was released on 2009-03-26 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook covers all aspects of dialysis treatment and the care of patients with renal failure in a clear, compact but detailed format.
Download or read book 1st International workshop on ABO incompatible kidney transplantation written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
