Download or read book Tissue Inhomogeneity Corrections for Megalovoltage Photon Beams written by and published by . This book was released on 2004 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Treatment Planning and Dose Calculation in Radiation Oncology written by Gunilla C. Bentel and published by Elsevier. This book was released on 2014-02-20 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment Planning and Dose Calculation in Radiation Oncology, Third Edition describes the treatment methods and technical guides as models of contemporary radiation therapy. These models should be modified for each individual patient to yield a best fit to the disease being treated and the radiation sources employed. This book is composed of seven chapters, and begins with an overview of the elements of clinical radiation oncology. The subsequent chapter deals with the production, interaction, and measurement of radiation. These topics are followed by intensive discussions of dose calculation for external beams and pretreatment procedures of radiation therapy. A chapter looks into the principles, apparatus, and dose calculation in brachytherapy. The final chapters describe the principles and practical applications of treatment planning. This book will be of value to radiation oncologists.

Download or read book Toxicological Risk Assessment and Multi System Health Impacts from Exposure written by Aristidis M. Tsatsakis and published by Elsevier. This book was released on 2021-08-01 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Download or read book Textbook of Radiation Oncology written by Steven A. Leibel and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.

Download or read book Accuracy Requirements and Uncertainties in Radiotherapy written by International Atomic Energy Agency and published by . This book was released on 2017-04-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accuracy requirements in radiation oncology have been defined in multiple publications; however, these have been based on differing radiation technologies. In the meantime, the uncertainties in radiation dosimetry reference standards have been reduced and more detailed patient outcome data are available. No comprehensive literature on accuracy and uncertainties in radiotherapy has been published so far. The IAEA has therefore developed a new international consensus document on accuracy requirements and uncertainties in radiation therapy, to promote safer and more effective patient treatments. This publication addresses accuracy and uncertainty issues related to the vast majority of radiotherapy departments including both external beam radiotherapy and brachytherapy. It covers clinical, radiobiological, dosimetric, technical and physical aspects.

Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Download or read book Assessment of the Scientific Information for the Radiation Exposure Screening and Education Program written by National Research Council and published by National Academies Press. This book was released on 2005-10-01 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Radiation Exposure Compensation Act (RECA) was set up by Congress in 1990 to compensate people who have been diagnosed with specified cancers and chronic diseases that could have resulted from exposure to nuclear-weapons tests at various U.S. test sites. Eligible claimants include civilian onsite participants, downwinders who lived in areas currently designated by RECA, and uranium workers and ore transporters who meet specified residence or exposure criteria. The Health Resources and Services Administration (HRSA), which oversees the screening, education, and referral services program for RECA populations, asked the National Academies to review its program and assess whether new scientific information could be used to improve its program and determine if additional populations or geographic areas should be covered under RECA. The report recommends Congress should establish a new science-based process using a method called "probability of causation/assigned share" (PC/AS) to determine eligibility for compensation. Because fallout may have been higher for people outside RECA-designated areas, the new PC/AS process should apply to all residents of the continental US, Alaska, Hawaii, and overseas US territories who have been diagnosed with specific RECA-compensable diseases and who may have been exposed, even in utero, to radiation from U.S. nuclear-weapons testing fallout. However, because the risks of radiation-induced disease are generally low at the exposure levels of concern in RECA populations, in most cases it is unlikely that exposure to radioactive fallout was a substantial contributing cause of cancer.

Download or read book Physics in Radiation Oncology Self Assessment Guide written by Ping Xia, PhD and published by Springer Publishing Company. This book was released on 2015-09-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide & companion to the Radiation Oncology Self-Assessment Guide is a comprehensive physics review for anyone in the field of radiation oncology looking to enhance their knowledge of medical physics. It covers in depth the principles of radiation physics as applied to radiation therapy along with their technical and clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly ìflash cardî question and answer format with over 800 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The Guide is comprised of 14 chapters that lead the reader through the radiation oncology physics field, from basic physics to current practice and latest innovations. Aspects of basic physics covered include fundamentals, photon and particle interactions, and dose measurement. A section on current practice covers treatment planning, safety, regulations, quality assurance, and SBRT, SRS, TBI, IMRT, and IGRT techniques. A chapter unique to this volume is dedicated to those topics in diagnostic imaging most relevant to radiology, including MRI, ultrasound, fluoroscopy, mammography, PET, SPECT, and CT. New technologies such as VMAT, novel IGRT devices, proton therapy, and MRI-guided therapy are also incorporated. Focused and authoritative, this must-have review combines the expertise of clinical radiation oncology and radiation physics faculty from the Cleveland Clinic Taussig Cancer Institute. Key Features: Includes more than 800 questions with detailed answers and rationales A one-stop guide for those studying the physics of radiation oncology including those wishing to reinforce their current knowledge of medical physics Delivered in a ìflash cardî format to facilitate recall of key concepts and data Presents a unique chapter on diagnostic imaging topics most relevant to radiation oncology Content provided by a vast array of contributors, including physicists, radiation oncology residents, dosimetrists, and physicians About the Editors: Andrew Godley, PhD, is Staff Physicist, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland OH Ping Xia, PhD, is Head of Medical Physics and Professor of Molecular Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

Download or read book Physiologically Based Pharmacokinetic PBPK Modeling written by Jeffrey W. Fisher and published by Academic Press. This book was released on 2020-05-20 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. - Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology - Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research - Authored by expert editors and contributors who are among the best PBPK modelers in the world

Download or read book Comprehensive Brachytherapy written by Jack Venselaar and published by Taylor & Francis. This book was released on 2012-11-08 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern brachytherapy is one of the most important oncological treatment modalities requiring an integrated approach that utilizes new technologies, advanced clinical imaging facilities, and a thorough understanding of the radiobiological effects on different tissues, the principles of physics, dosimetry techniques and protocols, and clinical expertise. A complete overview of the field, Comprehensive Brachytherapy: Physical and Clinical Aspects is a landmark publication, presenting a detailed account of the underlying physics, design, and implementation of the techniques, along with practical guidance for practitioners. Bridging the gap between research and application, this single source brings together the technological basis, radiation dosimetry, quality assurance, and fundamentals of brachytherapy. In addition, it presents discussion of the most recent clinical practice in brachytherapy including prostate, gynecology, breast, and other clinical treatment sites. Along with exploring new clinical protocols, it discusses major advances in imaging, robotics, dosimetry, Monte Carlo-based dose calculation, and optimization.

Download or read book Toxicological Evaluation of Electronic Nicotine Delivery Products written by Manuel C. Peitsch and published by Academic Press. This book was released on 2021-01-14 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation. - Delivers a comprehensive overview of current state of science - Offers an integrated analysis of e-cigarettes and heated tobacco products - Provides guidance for methodologies

Download or read book Physics for Clinical Oncology written by Amen Sibtain and published by Oxford University Press. This book was released on 2022-11-24 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiotherapy remains a major non-surgical treatment modality for malignant disease, and an understanding of how this treatment works is essential in ensuring optimum practice. Trainees in oncology learn about ionising radiation, but to understand it fully they must also understand the physics relevant to its use in therapy. This book is written specifically for the oncology and radiation team, supporting clinical oncologists in their understanding of the science which underpins radiotherapy. It begins with basic concepts and then explores the principles and practice of physics as it relates to radiotherapy, including discussion of specific types of therapy. Written by authors chosen for their expertise in in their respective fields, and aligned to the Royal College of Radiologists FRCR Curriculum in Oncology, this volume will provide an excellent source of information for trainee and practicing oncologists, and wider radiotherapy teams. This second edition has been fully updated to reflect advances in technology and the increased complexity in modern radiotherapy, including two new chapters on imaging and a new brachytherapy chapter.

Download or read book Spine Radiosurgery written by Peter Gerszten and published by Thieme. This book was released on 2015-08-19 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spine Radiosurgery, Second Edition , is a comprehensive text that includes discussions of the latest devices, treatment planning techniques, target definition, and patient selection in this specialty. Written by leading experts in the fields of neurosurgery, radiation oncology, and medical physics, this book is the definitive reference for clinical applications of state-of-the-art radiosurgery of the spine. Key Features: Six new chapters on such topics as histopathological examination of spinal lesions, minimally invasive techniques, and treatment of spinal chordomas More than 100 full-color illustrations demonstrate key concepts Discussion of new treatments for metastatic spine disease and spinal cord compression This book is a must-have resource for clinicians, fellows, and residents in neurosurgery and radiation oncology. Spine surgeons, orthopaedists, medical physicists, and oncologists at all levels will also benefit from the wealth of information provided.

Download or read book Development of Procedures for in Vivo Dosimetry in Radiotherapy written by International Atomic Energy Agency and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of the development of procedures for in vivo dosimetry in radiotherapy. It elaborates on the technology behind in vivo dosimetry and describes an initial set of measurements.

Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.