Download or read book A Study of the Mechanism of Retention in Reversed phase Liquid Chromatography written by Thomas Gerard Burke and published by . This book was released on 1980 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Study of Retention Mechanism in Reversed Phase Liquid Chromatography written by Lay Choo Tan and published by . This book was released on 1994 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stationary Phase Solvation and the Retention Mechanism in Reversed phase Liquid Chromatography written by Lynn Alison Cole and published by . This book was released on 1990 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigation of Retention Mechanisms in Reversed phase Liquid Chromatography with Reaction Kinetics written by Brian Scott Ludolph and published by . This book was released on 1989 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Understanding Retention Mechanisms and Adjusting Selectivity of Basic Pharmaceutical Separations by Reversed phase Liquid Chromatography written by Jun Dai and published by . This book was released on 2005 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Measurements of Limiting Activity Coefficients of Homologous Series of Solutes and Their Application to the Study of Retention Mechanism in Reversed Phase Liquid Chromatography written by Won Jo Cheong and published by . This book was released on 1989 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liquid Chromatography written by M.C. García-Álvarez-Coque and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The addition of reagents to an RPLC mobile phase enables the separation of ionizable compounds, inorganic anions, and metal ions using conventional instrumentation, silica-based materials, and hydro-organic mixtures, thanks to a variety of secondary equilibria. This gives rise to several chromatographic modes, whose main features are outlined in this chapter. The effect of the mobile phase pH on the retention of ionizable compounds is described, together with the recommended experimental practice. The mechanism of adsorption of amphiphilic anions or cations on the stationary phase to attract analytes with opposite charge or suppress the silanol activity is discussed. Different reagents, such as alkylammonium salts, surfactants (below and above the critical micelle concentration), perfluorinated carboxylate anions, chaotropic ions, and ionic liquids, are considered. The potential of metal chelation for the determination of metal ions and organic compounds is also summarized.

Download or read book Retention Mechanism of Some Basic Drugs on Reversed Phase Liquid Chromatography in the Presence of the Ionic Liquid BMIMBF4 written by Azhar Salman Alhejji and published by . This book was released on 2013 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Separation Methods in Drug Synthesis and Purification written by Klara Valko and published by Elsevier. This book was released on 2000-10-13 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Separation Methods in Drug Synthesis and Purification

Download or read book HPLC and UHPLC for Practicing Scientists written by Michael W. Dong and published by John Wiley & Sons. This book was released on 2019-07-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise yet comprehensive reference guide on HPLC/UHPLC that focuses on its fundamentals, latest developments, and best practices in the pharmaceutical and biotechnology industries Written for practitioners by an expert practitioner, this new edition of HPLC and UHPLC for Practicing Scientists adds numerous updates to its coverage of high-performance liquid chromatography, including comprehensive information on UHPLC (ultra-high-pressure liquid chromatography) and the continuing migration of HPLC to UHPLC, the modern standard platform. In addition to introducing readers to HPLC’s fundamentals, applications, and developments, the book describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. HPLC and UHPLC for Practicing Scientists, Second Edition offers three new chapters. One is a standalone chapter on UHPLC, covering concepts, benefits, practices, and potential issues. Another examines liquid chromatography/mass spectrometry (LC/MS). The third reviews at the analysis of recombinant biologics, particularly monoclonal antibodies (mAbs), used as therapeutics. While all chapters are revised in the new edition, five chapters are essentially rewritten (HPLC columns, instrumentation, pharmaceutical analysis, method development, and regulatory aspects). The book also includes problem and answer sections at the end of each chapter. Overviews fundamentals of HPLC to UHPLC, including theories, columns, and instruments with an abundance of tables, figures, and key references Features brand new chapters on UHPLC, LC/MS, and analysis of recombinant biologics Presents updated information on the best practices in method development, validation, operation, troubleshooting, and maintaining regulatory compliance for both HPLC and UHPLC Contains major revisions to all chapters of the first edition and substantial rewrites of chapters on HPLC columns, instrumentation, pharmaceutical analysis, method development, and regulatory aspects Includes end-of-chapter quizzes as assessment and learning aids Offers a reference guide to graduate students and practicing scientists in pharmaceutical, biotechnology, and other industries Filled with intuitive explanations, case studies, and clear figures, HPLC and UHPLC for Practicing Scientists, Second Edition is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology. It will be a great benefit to every busy laboratory analyst and researcher.

Download or read book Retention Mechanism for Reversed Phase and Hydrophilic Interaction Liquid Chromatography written by Sophie Bailes and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Structure written by Roman Kaliszan and published by Wiley-Interscience. This book was released on 1987-10-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.

Download or read book Retention and Selectivity in Liquid Chromatography written by R.M. Smith and published by Elsevier. This book was released on 1995-01-13 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.

Download or read book Liquid Chromatography written by R. Kaliszan and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of linear free-energy relationships, LFER, chromatographic systems are “free-energy transducers,” translating differences in the structure of analytes into quantitative differences in physicochemical properties, like retention parameters. Hence, quantitative structure property (retention) relationships, QSP(R)R, bear valuable information on analytes and the separation systems involved. We illustrate here what can be achieved from the statistically valid and physically meaningful quantitative structure-retention relationships, QSRR. In particular, one can predict retention data, confirm identification, and optimize conditions of separation of given structurally defined analytes. Also, QSPR can shed light on the molecular mechanism of separation operating on specific stationary phases. Additionally, one can assess such properties of drug analytes of pharmacokinetic importance, like lipophilicity and acidity. Also, differences in interactions of xenobiotics with biomacromolecule components of chromatographic systems can conveniently be quantified. By means of QSRR, the chromatographic behavior of analytes in diverse separation systems can be related to their pharmacological properties.

Download or read book Molecular Associations in Biology written by Bernard Pullman and published by . This book was released on 1968 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Structure retention Relationship Studies in Reversed phase Liquid Chromatography Intramolecular Hydrogen Bonding in Benzamides and Related Compounds written by Laura E. García Roura and published by . This book was released on 1987 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Basis of Chromatographic Separation written by Esther Forgacs and published by CRC Press. This book was released on 1997-07-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatographic separation is widely used in many scientific disciplines today, having an ever increasing number of scientific and technological applications. The widespread use of this rapid and powerful technique requires that it be fully understood, so that the most suitable may be determined for each possible separation problem in each possible domain of scientific research and technology. Molecular Basis of Chromatographic Separation provides complete coverage of the practical and molecular aspects of this popular technique. It compiles and evaluates recent results, outlines available methods, and discusses how to select the best method for a particular application.