Download or read book A Study of Pain Perception in Humans Using Functional Magnetic Resonance Imaging written by Elizabeth Ann Disbrow and published by . This book was released on 1996 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.
Download or read book Cortical Processing of Pain Perception in Humans written by Albert S. H. Ler and published by . This book was released on 1998 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Download or read book An Investigation of the Emotional Modulation of Pain Perception and Neural Processing in the Human Brainstem and Spinal Cord Using Functional Magnetic Resonance Imaging written by and published by . This book was released on 2014 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is an extremely subjective and complex sensory and emotional experience. It is affected by a range of factors including attention, suggestion, attitude, expectation, and affective state. The influence of emotion on pain perception and neural processing is the central focus of this thesis. Previous research has demonstrated that individuals exposed to a painful stimulus will rate that stimulus as more painful when accompanied by or associated with a negative emotional influence. Conversely, pain ratings decrease when the painful stimulus is coupled with a positive emotional influence. Although many studies have confirmed that emotional manipulations affect pain perception at a group level, there has been little exploration of the range in the effect size across individuals or the psychological characteristics that may act to mediate emotional modulation of pain. Furthermore, although there is a growing body of research exploring the neural response in the brain, no other study, to date, has used functional MRI to examine the neural response across the brainstem and spinal cord involved in emotional modulation of pain. As such, this thesis used a combination of behavioural measures and functional MRI to explore differences in the effect of emotional modulation on pain perception across individuals, along with the neural response in the brainstem and spinal cord. We observed a substantial degree of inter-subject variability for the emotional modulation of pain perception, along with significant correlations for scores on anxiety and depression questionnaires with the distinct effects for Positive and Negative emotional modulation of pain. Functional MRI results revealed an effect for emotional modulation of the neural response involved in pain processing in the ipsilateral dorsal horn of the spinal cord, along with several regions in the brainstem known to be involved in descending pain modulation. Functional connectivity of these areas was observed to vary based on the valence and arousal of the emotional stimuli. Therefore, the findings of this thesis provide novel insight into the subcortical neural network involved in emotional modulation of pain processing and the factors that influence the effect of emotions on pain perception.
Download or read book AN INVESTIGATION OF THE NEURAL CORRELATES OF COGNITIVE MODULATION OF PAIN PERCEPTION IN THE HUMAN BRAINSTEM AND CERVICAL SPINAL CORD USING FUNCTIONAL MAGNETIC RESONANCE IMAGING written by Roxanne Leung and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Download or read book Pain Imaging written by Kenneth Lyman Casey and published by . This book was released on 2000 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of the Cerebral Cortex in Pain Perception written by Patricia A. Gelnar and published by . This book was released on 1997 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Central Neuroanatomy of Pain and the Autonomic Nervous System in Humans written by Jane C. Topolovec and published by . This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Download or read book Duvernoy s Atlas of the Human Brain Stem and Cerebellum written by Thomas P. Naidich and published by Springer Science & Business Media. This book was released on 2009-06-25 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas instills a solid knowledge of anatomy by correlating thin-section brain anatomy with corresponding clinical magnetic resonance images in axial, coronal, and sagittal planes. The authors correlate advanced neuromelanin imaging, susceptibility-weighted imaging, and diffusion tensor tractography with clinical 3 and 4 T MRI. Each brain stem region is then analyzed with 9.4 T MRI to show the anatomy of the medulla, pons, midbrain, and portions of the diencephalonin with an in-plane resolution comparable to myelin- and Nissl-stained light microscopy. The book’s carefully organized diagrams and images teach with a minimum of text.
Download or read book Pain in Osteoarthritis written by David T. Felson and published by John Wiley & Sons. This book was released on 2010-08-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
Download or read book Neural Correlates of Inter Individual Differences in Pain Processing Investigated by Functional Magnetic Resonance Imaging of the Entire Central Nervous System written by and published by . This book was released on 2014 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The experience of pain is a highly complex and personal experience, characterized by tremendous inter-individual variability. Pain perception can differ substantially across individuals due to many factors such as age, gender, genetics, cognition and emotionality etc. Some individuals are very sensitive to pain whereas others tolerate pain well. Athletes can play competitive sports even with significant injuries while other people feel tremendous pain while getting a flu shot. This phenomenon of inter-individual variability in pain responses has challenged scientists and clinicians alike. It is difficult to determine whether subjective reports of pain reflect true individual experiences of pain. However, the development of neuroimaging techniques has dramatically progressed our understanding of pain processing. This project investigated the neural correlates of inter-individual differences in pain responses in healthy individuals, by means of functional magnetic resonance imaging (fMRI) of the entire central nervous system. Twenty-healthy participants were asked to rate their pain following a noxious thermal stimulus, while undergoing functional MRI, and considerable inter-individual variability was observed. Results from this project demonstrated central mechanisms in the brain, brainstem and spinal cord that contribute to this variability. Participants that reported higher pain to the noxious stimulus showed greater fMRI responses in some brain, brainstem and spinal cord structures involved in processing the emotional, cognitive and motivational aspects of pain. This showed that the subjective reports of pain are a reliable indicator, and inter-individual differences in pain responses truly reflect variability in pain experience. It is expected that this knowledge will contribute to a better understanding of the neuronal processes, as well as substantial inter-individual variability observed in chronic neuropathic pain populations such as fibromyalgia, patients with spinal cord injuries etc.
Download or read book Social Pain written by Geoff MacDonald and published by American Psychological Association (APA). This book was released on 2011 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Social pain is the experience of pain as a result of interpersonal rejection or loss, such as rejection from a social group, bullying, or the loss of a loved one. Research now shows that social pain results from the activation of certain components in physical pain systems. Although social, clinical, health, and developmental psychologists have each explored aspects of social pain, recent work from the neurosciences provides a coherent, unifying framework for integrative research. This edited volume provides the first comprehensive, multidisciplinary exploration of social pain. Part I examines the subject from a neuroscience perspective, outlining the evolutionary basis of social pain and tracing the genetic, neurological, and physiological underpinnings of the phenomenon. Part II explores the implications of social pain for functioning in interpersonal relationships; contributions examine the influence of painkillers on social emotions, the ability to relive past social hurts, and the relation of social pain to experiences of intimacy. Part III examines social pain from a biopsychosocial perspective in its consideration of the health implications of social pain, outlining the role of stress in social pain and the potential long-term health consequences of bullying. The book concludes with an integrative review of these diverse perspectives"--Publicity materials. (PsycINFO Database Record (c) 2010 APA, all rights reserved).
Download or read book Functional Magnetic Resonance Imaging of Pain in the Spinal Cord and Brainstem written by Niousha Foad Ghazni and published by . This book was released on 2008 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional magnetic resonance imaging (fMRI) studies performed to date have focused on brain structures rostral to the thalamus, although the first level of sensory information and pain transmission occurs at the spinal cord (SC). The primary goal of this project is to map activity using fMRI, from the entire cervical SC and brainstem following innocuous and noxious stimuli before and after peripheral sensitization in normal human volunteers. This study is unique in that it determines functional activity throughout the lower neural axis in response to mechanical stimuli that are perceived as painful only after sensitization. Functional MRI studies of the SC were carried out in 18 healthy individuals in a 3T Siemens Magnetom Trio. Innocuous touch and brush (n=8), and noxious touch (n=10) stimuli were applied before and after peripheral sensitization. Peripheral sensitization was induced by topical application of capsaicin. Functional image data spanned from the C7/T1 disc to the superior edge of the thalamus and analyzed using a general linear model to discriminate signal intensity changes from physiological motion. Normalized results were combined to demonstrate the number of volunteers showing activity at each location on a voxel-by-voxel basis. Areas of activity were superimposed onto anatomical transverse drawings and identified visually with comparison to several stereotaxic atlases. The results from this study confirm previous reports that a non-noxious stimulus translates into a pain response after peripheral sensitization. The brush stimulus, before sensitization activated areas in the ipsilateral dorsal horn (DH), gracile and cuneate nuclei in the medulla and areas surrounding the dorsal column medial lemniscal pathway. Peripheral sensitization produced activity in the contralateral ventral horn (VH), typical of a pain response. The innocuous von Frey stimulus produced activity in typical sensory centres in the DH and brainstem before sensitization, and areas more consistent with a noxious response after sensitization. When examining equi-nociceptive stimuli in a control versus sensitized state, the noxious touch stimuli showed similar activation patterns even though the force of the filaments were different. In all experiments there was indication of descending modulation as activity was observed in the periaqueductal gray, midbrain red nuclei and pontine reticular formation. This study demonstrates how non-painful and pain information is transmitted from the dorsal spinal horn to the brain in healthy individuals and how peripheral sensitization induces changes in non-noxious stimuli that correlate with pain sensory transmission.
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
