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Book Translational Medicine

    Book Details:
  • Author : Joy A. Cavagnaro
  • Publisher : CRC Press
  • Release : 2021-11-26
  • ISBN : 1000471853
  • Pages : 952 pages

Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Book Critical Theory Ethics for Business and Public Administration

Download or read book Critical Theory Ethics for Business and Public Administration written by David M. Boje and published by IAP. This book was released on 2008-09-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to develop those ethical traditions. For example, Horkheimer’s books Eclipse of Reason and Critique of Instrumental Reason, and his early and now classic essay Materialism and Morality ask for a reformation of Kantian ethics. The reform sought is that categorical imperative in an individualism capitalism serves to worsen the difference between business ethics and moral philosophy. That is, it is not enough to try to be good or ethical as individuals when it is the systemic processes that must be dealt with. Therefore, Horkheimer asks that the maxim that would be made universal be done at the level of people organizing with others to change the social system that is producing the unethical behaviors. The book is organized into several sections. The first section sets the stages, beginning with a challenge to the field of social responsibility in business and public administration (Jones, Ten bos, & Parker have a new book out that is smashing). Then, we turn to Carr and to Zanettic who each have done critical theory work in public administration. This is followed by Heather Hopfl, who edited an issue on ethics of goodness, and does the kind of writing that makes deep connections. The next set of chapters make topic connections: rhizomatics, dialogics of co experience, story/narrative, and postmodern. The third set of topics focus on application: technofuturist, international business, economics, university, environment, accounting, spirituality, strategy, and ending with Mills’ work on silence of race/ethnicity in business (and public administration) ethics writing.

Book Architecture of Brazil

    Book Details:
  • Author : Hugo Segawa
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-05
  • ISBN : 146145431X
  • Pages : 276 pages

Download or read book Architecture of Brazil written by Hugo Segawa and published by Springer Science & Business Media. This book was released on 2012-12-05 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Architecture of Brazil: 1900-1990 examines the processes that underpin modern Brazilian architecture under various influences and characterizes different understandings of modernity, evident in the chapter topics of this book. Accordingly, the author does not give overall preference to particular architects nor works, with the exception of a few specific works and architects, including Warchavchik, Niemeyer, Lucio Costa, and Vilanova Artigas.

Book Pulping the South

Download or read book Pulping the South written by Ricardo Carriere and published by Zed Books. This book was released on 1996-08-15 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expansion of the pulp and paper industry is one of the most important causes of land and water conflicts in the South. This book examines the threat to livelihood, soil and biodiversity generated by large-scale pulpwood plantations in the South.

Book Management of Nuclear Power Plant Projects

Download or read book Management of Nuclear Power Plant Projects written by IAEA and published by International Atomic Energy Agency. This book was released on 2020-11-25 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Member States intending to introduce a nuclear power programme will need to pass through several phases during the implementation. Experience shows that careful planning of the objectives, roles, responsibilities, interfaces and tasks to be carried out in different phases of a nuclear project is important for success. This publication presents a harmonized approach that may be used to structure the owner/operator management system and establish and manage nuclear projects and their development activities irrespective of the adopted approach. It has been developed from shared management practices and consolidated experiences provided by nuclear project management specialists through a series of workshops and working groups organized by the IAEA. The resultant publication presents a useful framework for the management of nuclear projects from initiation to closeout and captures international best practices.

Book A Frequency Dictionary of Portuguese

Download or read book A Frequency Dictionary of Portuguese written by Mark Davies and published by Routledge. This book was released on 2007-11-29 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable tool for learners of Portuguese, this Frequency Dictionary provides a list of the 5000 most commonly used words in the language. Based on a twenty-million-word collection of Portuguese (taken from both Portuguese and Brazilian sources), which includes both written and spoken material, this dictionary provides detailed information for each of the 5000 entries, including the English equivalent, a sample sentence, and an indication of register and dialect variation. Users can access the top 5000 words either through the main frequency listing or through an alphabetical index. Throughout the frequency listing there are also thrity thematically-organized ‘boxed’ lists of the top words from a variety of key topics such as sports, weather, clothing and relations. An engaging and highly useful resource, A Frequency Dictionary of Portuguese will enable students of all levels to get the most out of their study of Portuguese vocabulary. Former CD content is now available to access at www.routledge.com/9780415419970 as support material. Designed for use by corpus and computational linguists it provides the full text in a format that researchers can process and turn into suitable lists for their own research work.

Book Foreign Direct Investment in Latin America and the Caribbean 2010

Download or read book Foreign Direct Investment in Latin America and the Caribbean 2010 written by United Nations and published by UN. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2010, the Latin American and Caribbean region showed great resilience to the international financial crisis and became the world region with the fastest-growing flows of both inward and outward foreign direct investment (FDI). The upswing in FDI in the region has occurred in a context in which developing countries in general have taken on a greater share in both inward and outward FDI flows. This briefing paper is divided into five sections. The first offers a regional overview of FDI in 2010. The second examines FDI trends in Central America, Panama and the Dominican Republic. The third describes the presence China is beginning to build up as an investor in the region. Lastly, the fourth and fifth sections analyze the main foreign investments and business strategies in the telecommunications and software sectors, respectively.

Book Cape Verde

    Book Details:
  • Author : Ana Mafalda Leite
  • Publisher : Tagus
  • Release : 2002-11
  • ISBN :
  • Pages : 564 pages

Download or read book Cape Verde written by Ana Mafalda Leite and published by Tagus. This book was released on 2002-11 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of scholars from Cape Verde, Brazil, Portugal, the United States, the United Kingdom and Spain writing about Cape Verde

Book Triassic Jurassic Rifting

Download or read book Triassic Jurassic Rifting written by W. Manspeizer and published by Elsevier. This book was released on 2015-08-26 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive field studies on the African and North American plates during this past decade have yielded a wealth of new data and ideas about rift basins and the origin of passive margins. New surface and subsurface basins have been identified; fossils abound in strata that only recently were considered barren; oil exploration is being actively pursued in continental strata of the Richmond-Taylorsville, Sanford and Newark basins, Late Triassic marine strata have been identified in Georges Bank off the coast of Massachusetts, and the roles of wrench tectonics, successor basins and listric normal faults have challenged the classical view that these are simple extensional basins.This two part work brings together representative examples of these studies. It is not intended as an exhaustive synthesis of the subject, but rather a vehicle to present new data, new ideas and alternative views. Some of the papers present regional summaries, others attempt to relate local features to regional questions, while others describe modern rift basins as possible analogs of early Mesozoic basins.Geologic data from the Atlantic passive margins record that continental rifting of central Pangaea occurred during the latest Triassic-earliest Jurassic (Liassic), and that sea-floor spreading probably began no later than the Middle Jurassic. The primary subject of this book focuses on the Triassic-Jurassic rifting events that led to the breakup of Pangaea and the opening of the central Atlantic Ocean. Whereas other treatises have focused on the origin of the passive margins, inferred primarily from geophysical data of the offshore basins, this volume primarily and uniquely focuses on land-based field studies of the onshore synrift basins. Offshore studies of synrift basins are also included and add substantially to our understanding of the breakup. However, the onshore data base, while complementary, is different, thus providing researchers with a different insight to the questions at hand.The book is organized into four sections. Section I, Pangaean Plate in Time and Space, first locates Pangaea in space and then places the Triassic basins within an historical context on the Alleghanian-Variscan Orogens. Section 2, the offshore and onshore basins of the North American and African Plates, comprises about 70% of all papers in this book, and includes papers on structural geology, petrology, paleontology, sedimentation, organic geochemistry, vulcanism and mineral resources. Section 3, Related Mesozoic Atlantic Rift Basins, includes papers on Iberia, Western Europe, the Benue Trough and Brazil. The final section of the book, Analogs, includes the rift basins of East Africa, the Red Sea, the Gulf of Elat (Aqaba), the Dead Sea and the Rio Grande.The book is richly illustrated throughout with figures, photographs, tables and fold-out maps, including nine in full colour.

Book Atlantic Rifts and Continental Margins

Download or read book Atlantic Rifts and Continental Margins written by Webster Mohriak and published by American Geophysical Union. This book was released on 2000-01-10 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference on the geology and geophysics of continental margins contains a total of 15 papers developed from a session of the Fifth International Congress of the Brazilian Geophysical Society held in Sao Paulo, Brazil in 1997, as well as a number of other contributions. Subjects include the roots of the southeastern continental margin of Brazil, the mosaic of Terranes in central Europe, the evolution of the Angolan passive margin; geological and geophysical interpretation of the San Julian Basin offshore Argentina; and the tectonic evolution of the equatorial South Atlantic. Of likely interest to academic geoscientists working in basin analysis and those engaged in petroleum exploration. Member price, $52.50. Annotation copyrighted by Book News, Inc., Portland, OR.

Book Imperial Migrations

Download or read book Imperial Migrations written by E. Morier-Genoud and published by Springer. This book was released on 2012-12-15 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume investigates what role colonial communities and diaspora have had in shaping the Portuguese empire and its heritage, exploring topics such as Portuguese migration to Africa, the Ismaili and the Swiss presence in Mozambique, the Goanese in East Africa, the Chinese in Brazil, and the history of the African presence in Portugal.

Book Civil and Commercial Mediation in Europe  set   Vols  1 2

Download or read book Civil and Commercial Mediation in Europe set Vols 1 2 written by Carlos Esplugues Mota and published by . This book was released on 2014-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally available as two separate volumes, Intersentia's Civil and Commercial Mediation in Europe is now available as a two volume set. *** About Volume I on National Mediation Rules and Procedures: Mediation is becoming an increasingly important tool for resolving civil and commercial disputes. Although it has been long since recognized in many legal systems, in recent years it has received an important boost and is currently one of the most topical issues in the field of dispute resolution. The European Directive 2008/52/EC of the European Parliament and of the Council of 21.5.2008 on certain aspects of mediation in civil and commercial matters, prescribes a set of minimum common rules on mediation for all EU Member States, with the exception of Denmark. This book examines the current legal framework in every EU Member State regarding mediation in civil and commercial matters, as well as the way in which the Directive has been, or is expected to be, implemented in the near future. It is written by renowned specialists on mediation in Europe and provides an exhaustive account for both scholars and practitioners in Europe and beyond the continent. Every chapter on national law analyzes: both out-of-court and court-annexed mediation in the existing legal framework * the areas of law covered by mediation * the value and formal requirements of the agreement to submit any dispute to mediation * personal features and requirements for mediators * procedural requirements in the mediation procedure * the relationship between the mediator and public authorities * the outcome of the mediation procedure * in the scenario in which a mediation settlement is reached, its requirements and effects. *** About Volume II on Cross-Border Mediation: Mediation plays a leading role within the movement of Alternative Dispute Resolution after centuries in which for several reasons the State and State courts were regarded as the only available instrument to ensure access to justice to citizens. In the European Union the institution of mediation has received much support in the form of Directive 2008/52/EC which sets forth a minimum common legal framework for mediation in the Member States. The 2008 Directive has finally been implemented in the Member States and this book provides the much needed in-depth analysis of the status of the mediation regimes in the European Union. The analysis covers the legal regimes of the Member States set up for cross-border and national mediation. This volume includes national reports on cross-border mediation including in-depth information on all the relevant aspects of cross-border mediation: the notion of cross-border mediation, the law applicable to the mediation clause, the mediation proceedings and the content of the settlement reached by the parties. Special attention is of course given to the recognition and enforcement in the European Union of settlements reached in other Member States and outside Europe. In addition the role of mediators and requirements to become a mediator are examined. This book provides a unique picture of the legal situation in the European Union for cross-border mediation. It is an invaluable instrument for those who want to know more about this complex topic or want to become a mediator in Europe themselves.

Book Learning Styles and Strategies for Management Students

Download or read book Learning Styles and Strategies for Management Students written by Carvalho, Luísa Cagica and published by IGI Global. This book was released on 2020-03-27 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, globalization, advances in technology, greater access to information, and communication via social networks generate an explosion of knowledge and cause the working world to experience rapid change based on knowledge and continuous learning. The challenge for universities is to have a curriculum that prepares students for this digital world, but many characteristics of the school curriculum have been unchanged for decades. Consequently, student experiences can be very different from the experiences required by the labor market. In a learning environment, the desired results will not be achieved if several essential elements are not considered in the instructional teaching process, including learning style, age, and maturity level. Learning Styles and Strategies for Management Students is a critical scholarly resource that provides essential research on the growing recognition of the critical role of education through concepts and principles of styles and strategies of learning. Additionally, it explores key developments in the methodologies, strategies, and learning styles of students, mainly in management studies. Featuring an array of topics such as digital education, sustainability, and management, this book is ideal for academicians, researchers, administrators, curriculum designers, policymakers, practitioners, and students.

Book The Colours of the Empire

Download or read book The Colours of the Empire written by Patrícia Ferraz de Matos and published by Berghahn Books. This book was released on 2013-02-01 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Portuguese Colonial Empire established its base in Africa in the fifteenth century and would not be dissolved until 1975. This book investigates how the different populations under Portuguese rule were represented within the context of the Colonial Empire by examining the relationship between these representations and the meanings attached to the notion of ‘race’. Colour, for example, an apparently objective criterion of classification, became a synonym or near-synonym for ‘race’, a more abstract notion for which attempts were made to establish scientific credibility. Through her analysis of government documents, colonial propaganda materials and interviews, the author employs an anthropological perspective to examine how the existence of racist theories, originating in the eighteenth and nineteenth centuries, went on to inform the policy of the Estado Novo (Second Republic, 1933–1974) and the production of academic literature on ‘race’ in Portugal. This study provides insight into the relationship between the racist formulations disseminated in Portugal and the racist theories produced from the eighteenth century onward in Europe and beyond.

Book Transnational Challenges to National History Writing

Download or read book Transnational Challenges to National History Writing written by M. Middell and published by Palgrave Macmillan. This book was released on 2015-07-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays argues that there is an pre-history, that is, a longer tradition of the transnationalization of historical culture and historical science. It seeks to substantiate the claim that history writing reflected the globality of its time as much as followed the nationalization of the societies in which it was produced.

Book Our Creative Diversity

Download or read book Our Creative Diversity written by World Commission on Culture and Development and published by . This book was released on 1996 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the interactions between culture and development and puts forward proposals in the form of an international agenda aimed at motivating people to recognize cultural challenges.