Download or read book A Parp in the Dark written by John Wood and published by BookLife Accessible Readers. This book was released on 2022-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An awful smell ruins the clowns' road trip. One of them is guilty - but who?
Download or read book Poly ADP Ribosyl ation written by Alexander Bürkle and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Oxidative Damage to Nucleic Acids written by Mark D. Evans and published by Springer Science & Business Media. This book was released on 2009-06-11 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Download or read book Drug Resistance in Leukemia and Lymphoma III written by G.J.L. Kaspers and published by Springer Science & Business Media. This book was released on 1999-09-30 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular drug resistance is a major limitation to the success of chemotherapy of leu kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.
Download or read book Plant Pathology Concepts and Laboratory Exercises written by Robert N. Trigiano and published by CRC Press. This book was released on 2007-11-30 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and updated with new concepts, case studies, and laboratory exercises, Plant Pathology Concepts and Laboratory Exercises, Second Edition supplies highly detailed and accurate information in a well-organized and accessible format. New additions to the second edition include five new topic and exercise chapters on soilborne pathogens, molecular tools, biocontrol, and plant-fungal interactions, information on in vitro pathology, an appendix on plant pathology careers, and how to use and care for the microscope. An accompanying cd-rom contains figures from the text as well as supplemental full-color photos and PowerPoint slides. Unique Learning Tools Retaining the informal style of the previous edition, this volume begins each topic with a concept box to highlight important ideas. Several laboratory exercises support each topic and cater to a wide range of skill sets from basic to complex. Procedure boxes for the experimental exercises give detailed outlines and comments on the experiments, step by step instruction, anticipated results, and thought provoking questions. Case studies of specific diseases and processes are presented as a bulleted list supplying essential information at a glance. Comprehensive Coverage Divided into six primary parts, this valuable reference introduces basic concepts of plant pathology with historical perspectives, fundamental ideas of disease, and disease relationships with the environment. It details various disease-causing organisms including viruses, prokaryotic organisms, plant parasitic nematodes, fungi, plant parasitic seed plants, and other biotic and abiotic diseases. Exploring various plant-pathogen interactions including treatments of molecular attack strategies, extracellular enzymes, host defenses, and disruption of plant function, the book presents the basic ideas of epidemiology, control strategies, and disease diagnosis.
Download or read book Darkness at Noon written by Arthur Koestler and published by . This book was released on 1940 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Cell Death written by Csaba Szabo and published by CRC Press. This book was released on 2000-06-22 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
Download or read book The Night Watch written by Sarah Waters and published by Bloomsbury Publishing. This book was released on 2016-07-28 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: I thought everything would change, after the war. And now, no one even mentions it. It is as if we all got together in private and said whatever you do don't mention that, like it never happened. It's the late 1940s. Calm has returned to London and five people are recovering from the chaos of war. In scenes set in a quiet dating agency, a bombed-out church and a prison cell, the stories of these five lives begin to intertwine and we uncover the desire and regret that has bound them together. Sarah Waters's story of illicit love and everyday heroism takes us from a dazed and shattered post-war Britain back into the heart of the Blitz, towards the secrets that are hidden there. Olivier-nominated playwright Hattie Naylor has created a thrilling and theatrically inventive adaptation of a great modern novel. The stage adaptation of The Night Watch was premiered at the Royal Exchange Theatre, Manchester, on 16 May 2016.
Download or read book The Unadulterated Cat written by Terry Pratchett and published by Orion. This book was released on 2002 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Unadulterated Cat is becoming an endangered species as more and more of us settle for those boring mass-produced cats the ad-men sell us - the pussies that purr into their gold-plated food bowls on the telly. But the Campaign for Real Cats sets out to change all that by helping us to recognise a true, unadulterated cat when we see one. For example: real cats have ears that look like they've been trimmed with pinking shears; real cats never wear flea collars . . . or appear on Christmas cards . . . or chase anything with a bell in it; real cats do eat quiche. And giblets. And butter. And anything else left on the table, if they think they can get away with it. Real cats can hear a fridge door opening two rooms away . . .
Download or read book Current Topics in Developmental Biology written by Gerald P. Schatten and published by Elsevier. This book was released on 2003-11-07 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with other volumes in this series, Volume 56 of Current Topics in Developmental Biology presents thoughtful and forward-looking articles on developmental biology and developmental medicine. Reviews include: Selfishness in moderation: evolutionary success of the yeast plasmid Nongenomic actions of androgen in sertoli cells Regulation of chromatin structure and gene activity by Poly(ADP-ribose) polymerases Centromeres and Kinetochores, Who Needs 'Em? The Role of Non-centromeric Chromatin in Spindle Assembly Modeling Cardiogenesis: The Challenges and Promises of 3D Reconstruction Plasmid and Chromosome Traffic Control: How ParA and ParB Drive Partition The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development. Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine The longest-running forum for contemporary issues in developmental biology with over 30 years of coverage
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Download or read book Dinosaurs Before Dark written by Mary Pope Osborne and published by Random House Books for Young Readers. This book was released on 2012 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eight-year-old Jack and his younger sister Annie find a magic treehouse, which whisks them back to an ancient time zone where they see live dinosaurs.
Download or read book Hyperbole and a Half written by Allie Brosh and published by Simon and Schuster. This book was released on 2013-10-29 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 New York Times Bestseller “Funny and smart as hell” (Bill Gates), Allie Brosh’s Hyperbole and a Half showcases her unique voice, leaping wit, and her ability to capture complex emotions with deceptively simple illustrations. FROM THE PUBLISHER: Every time Allie Brosh posts something new on her hugely popular blog Hyperbole and a Half the internet rejoices. This full-color, beautifully illustrated edition features more than fifty percent new content, with ten never-before-seen essays and one wholly revised and expanded piece as well as classics from the website like, “The God of Cake,” “Dogs Don’t Understand Basic Concepts Like Moving,” and her astonishing, “Adventures in Depression,” and “Depression Part Two,” which have been hailed as some of the most insightful meditations on the disease ever written. Brosh’s debut marks the launch of a major new American humorist who will surely make even the biggest scrooge or snob laugh. We dare you not to. FROM THE AUTHOR: This is a book I wrote. Because I wrote it, I had to figure out what to put on the back cover to explain what it is. I tried to write a long, third-person summary that would imply how great the book is and also sound vaguely authoritative—like maybe someone who isn’t me wrote it—but I soon discovered that I’m not sneaky enough to pull it off convincingly. So I decided to just make a list of things that are in the book: Pictures Words Stories about things that happened to me Stories about things that happened to other people because of me Eight billion dollars* Stories about dogs The secret to eternal happiness* *These are lies. Perhaps I have underestimated my sneakiness!
Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.
Download or read book The Science of Storytelling written by Will Storr and published by Abrams. This book was released on 2020-03-10 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compelling, groundbreaking guide to creative writing that reveals how the brain responds to storytelling Stories shape who we are. They drive us to act out our dreams and ambitions and mold our beliefs. Storytelling is an essential part of what makes us human. So, how do master storytellers compel us? In The Science of Storytelling, award-winning writer and acclaimed teacher of creative writing Will Storr applies dazzling psychological research and cutting-edge neuroscience to our myths and archetypes to show how we can write better stories, revealing, among other things, how storytellers—and also our brains—create worlds by being attuned to moments of unexpected change. Will Storr’s superbly chosen examples range from Harry Potter to Jane Austen to Alice Walker, Greek drama to Russian novels to Native American folk tales, King Lear to Breaking Bad to children’s stories. With sections such as “The Dramatic Question,” “Creating a World,” and “Plot, Endings, and Meaning,” as well as a practical, step-by-step appendix dedicated to “The Sacred Flaw Approach,” The Science of Storytelling reveals just what makes stories work, placing it alongside such creative writing classics as John Yorke’s Into the Woods: A Five-Act Journey into Story and Lajos Egri’s The Art of Dramatic Writing. Enlightening and empowering, The Science of Storytelling is destined to become an invaluable resource for writers of all stripes, whether novelist, screenwriter, playwright, or writer of creative or traditional nonfiction.
