Download or read book A Novel Method for Predicting Product Properties in Fluidized Bed Spray Granulation Band 19 written by Paul Kieckhefen and published by Cuvillier Verlag. This book was released on 2022-01-03 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidized bed spray granulation is a process that facilities particle size enlargement by injecting solids in the form of a suspension, solution or melt. The produced particles are often of high value due to their highly specific, functionalized nature. This work provides a method for utilizing particle-scale simulations method like the coupled Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) to predict the properties of particles produced in scaled-up apparatuses based on laboratory-scale experiments by correlating the conditions that particle experience to the properties they develop. Furthermore, a method for calibrating DEM models of weakly wetted particle systems by utilizing a novel, probabilistic liquid bridge state model is proposed.
Download or read book Discrete particle modeling of a fluidized bed granulator written by Lennart Fries and published by Cuvillier Verlag. This book was released on 2012-10-29 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Size-enlargement and structuration processes in fluidized beds such as granulation and agglomeration play an important role in the pharmaceutical and fine chemical industries as well as in food technology to improve the flowability and the instant properties of solid products. Dustfree and free-flowing particles can be produced in a process with favourable heat- and mass transfer conditions. Furthermore, this technology allows the formulation of particles with novel functionalities by applying coating layers or via the encapsulation of active ingredients. Several interdependent micro mechanisms including particle collisions, wetting, drying and phase transitions govern the process dynamics and complicate predictions on the effect of variable operating conditions on product properties such as structure, strength and re-dissolution behaviour. Profound knowledge on these mechanisms is needed to understand the influence of individual process parameters on the final product properties. A suitable approach to model the particle interactions in fluidized beds is the Discrete Element Method (DEM) coupled with Computational Fluid Dynamics (CFD). Information on gas and particle velocities, particle rotation and collision dynamics, which are very complicated to measure in fluidized beds, can be studied in detail with this technique. This thesis presents DEM-CFD simulation results for three different granulator configurations (top-spray, Wurster-coater, spouted bed) in comparison to experimental results, regarding the agglomeration of amorphous maltodextrin (DE 21). In simulation and experiment the identical geometry of the equipment was used. Mechanical material properties, such as the coefficient of restitution and the Young’s modulus, which are required for the DEM model and which are frequently used as fitting parameters, were measured via static and dynamic deformation tests using maltodextrin agglomerates, beads and bars. The strength of the experimentally produced agglomerates was characterized with a compression tester. Their flow behaviour was assessed with the help of a shear cell. Very promising results were obtained showing that the homogeneity of particle wetting can well be approximated with the residence time distribution of the particles inside the spray zone.Homogeneous wetting allows achieving a narrow product size distribution (Fries et al., 2011a).Furthermore, the growth rate of the agglomerates can well be correlated with the simulated wetting intensity, the collision frequency and the collision velocity distribution inside the spray zone. The agglomerate strength shows a strong correlation with the particle-wall collision frequency and velocity distribution found in the simulations. Good agreement was found between the simulation results for the maximum particle deformation and for the energy dissipation during collisions and the measured deformation at the breakage point and the breakage energy. Due to the high numerical effort, DEM is only suitable for small scale applications. However, the obtained information on the kinetics of particle-particle interactions can be applied as input for macroscopic process models in the framework of a multi scale modeling scheme (Fries et al., 2011b; Werther et al., 2011). It can be concluded that DEM is a powerful tool for the detailed characterization of fluidized bed granulators. Highly relevant practical answers can be obtained from the model such as the choice of the optimal equipment geometry depending on material properties and product requirements. The model can point out where to position the spray nozzles in order to achieve homogeneous particle wetting and if a draft tube is helpful to maintain stable particle circulation. Based on such findings the model shows potential to increase the throughput of a fluidized bed granulator, while avoiding a bed collapse.
Download or read book Handbook of Pharmaceutical Granulation Technology written by Dilip M. Parikh and published by CRC Press. This book was released on 2021-05-11 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fluidized Bed Reactors Processes and Operating Conditions written by John G. Yates and published by Springer. This book was released on 2016-09-27 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluidized-bed reactor is the centerpiece of industrial fluidization processes. This book focuses on the design and operation of fluidized beds in many different industrial processes, emphasizing the rationale for choosing fluidized beds for each particular process. The book starts with a brief history of fluidization from its inception in the 1940’s. The authors present both the fluid dynamics of gas-solid fluidized beds and the extensive experimental studies of operating systems and they set them in the context of operating processes that use fluid-bed reactors. Chemical engineering students and postdocs as well as practicing engineers will find great interest in this book.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Design and Processing of Particulate Products written by Jim Litster and published by Cambridge University Press. This book was released on 2016-10-20 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique text providing comprehensive coverage of fundamental particle science, processing and technology. Including quantitative tools, real-world case studies and end-of-chapter problems, it is ideal for students in engineering and applied sciences, as well as for practitioners in a range of industries manufacturing particulate products.
Download or read book The Science and Engineering of Granulation Processes written by Jim Litster and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the Particle Science and Technology Research Center in Dupont). As we played in the sand, we shared an excitement for developments in particle technology, especially particle characterization, that would lead operations such as granulation to be placed on a sound scientific and engineering footing. The immediate outcome from this interaction was the development of new industry short courses in granulation and related topics which we taught together both in Australia and North America. This book follows closely the structure and approaches developed in these courses, particularly the emphasis on particle design in granulation, where the impact of both formulation properties and process variables on product attributes needs to be understood and quantified. The book has been a long time in the making. We have been actively preparing the book for at least five years. Although the chapters have relatively good bibliographies, this book is not a review of the field. Rather it is an attempt by the authors to present a comprehensive engineering approach to granulator design, scale up and operation. It is exciting for us to see the explosion of research interest around the world in this area in the last five to seven years. Some of the most recent work will have to find its way into the second edition.
Download or read book Fluid Bed Technology in Materials Processing written by C. K. Gupta and published by CRC Press. This book was released on 1998-12-28 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluid Bed Technology in Materials Processing comprehensively covers the various aspects of fluidization engineering and presents an elaborate examination of the applications in a multitude of materials processing techniques. This singular resource discusses: All the basic aspects of fluidization essential to understand and learn about various techniques The range of industrial applications Several examples in extraction and process metallurgy Fluidization in nuclear engineering and nuclear fuel cycle with numerous examples Innovative techniques and several advanced concepts of fluidization engineering, including use and applications in materials processing as well as environmental and bio-engineering Pros and cons of various fluidization equipment and specialty of their applications, including several examples Design aspects and modeling Topics related to distributors effects and flow regimes A separate chapter outlines the importance of fluidization engineering in high temperature processing, including an analysis of the fundamental concepts and applications of high temperature fluidized bed furnaces for several advanced materials processing techniques. Presenting information usually not available in a single source, Fluid Bed Technology in Materials Processing serves Fluidization engineers Practicing engineers in process metallurgy, mineral engineering, and chemical metallurgy Researchers in the field of chemical, metallurgical, nuclear, biological, environmental engineering Energy engineering professionals High temperature scientists and engineers Students and professionals who adopt modeling of fluidization in their venture for design and scale up
Download or read book 26th European Symposium on Computer Aided Process Engineering written by and published by Elsevier. This book was released on 2016-06-17 with total page 2486 pages. Available in PDF, EPUB and Kindle. Book excerpt: 26th European Symposium on Computer Aided Process Engineering contains the papers presented at the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event held at Portorož Slovenia, from June 12th to June 15th, 2016. Themes discussed at the conference include Process-product Synthesis, Design and Integration, Modelling, Numerical analysis, Simulation and Optimization, Process Operations and Control and Education in CAPE/PSE. Presents findings and discussions from the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event
Download or read book Predictive Modeling of Pharmaceutical Unit Operations written by Preetanshu Pandey and published by Woodhead Publishing. This book was released on 2016-09-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points
Download or read book Current Awareness in Particle Technology written by and published by . This book was released on 1993 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spray Drying Techniques for Food Ingredient Encapsulation written by C. Anandharamakrishnan and published by John Wiley & Sons. This book was released on 2015-07-23 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spray drying is a well-established method for transforming liquid materials into dry powder form. Widely used in the food and pharmaceutical industries, this technology produces high quality powders with low moisture content, resulting in a wide range of shelf stable food and other biologically significant products. Encapsulation technology for bioactive compounds has gained momentum in the last few decades and a series of valuable food compounds, namely flavours, carotenoids and microbial cells have been successfully encapsulated using spray drying. Spray Drying Technique for Food Ingredient Encapsulation provides an insight into the engineering aspects of the spray drying process in relation to the encapsulation of food ingredients, choice of wall materials, and an overview of the various food ingredients encapsulated using spray drying. The book also throws light upon the recent advancements in the field of encapsulation by spray drying, i.e., nanospray dryers for production of nanocapsules and computational fluid dynamics (CFD) modeling. Addressing the basics of the technology and its applications, the book will be a reference for scientists, engineers and product developers in the industry.
Download or read book Food Powders written by Enrique Ortega-Rivas and published by Springer Science & Business Media. This book was released on 2006-04-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful reference is the first book to address key aspects of food powder technology. It assembles organized and updated information on the physical properties, production, and functionality of food powder, previously unavailable in book form.
Download or read book Process Modelling and Simulation written by César de Prada and published by MDPI. This book was released on 2019-09-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.
Download or read book Handbook of Fluidization and Fluid Particle Systems written by Wen-Ching Yang and published by CRC Press. This book was released on 2003-03-19 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference details particle characterization, dynamics, manufacturing, handling, and processing for the employment of multiphase reactors, as well as procedures in reactor scale-up and design for applications in the chemical, mineral, petroleum, power, cement and pharmaceuticals industries. The authors discuss flow through fixed beds, elutriation and entrainment, gas distributor and plenum design in fluidized beds, effect of internal tubes and baffles, general approaches to reactor design, applications for gasifiers and combustors, dilute phase pneumatic conveying, and applications for chemical production and processing. This is a valuable guide for chemists and engineers to use in their day-to-day work.
Download or read book Aulton s Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
