Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Download or read book Statistics in Toxicology written by Byron J. T. Morgan and published by Oxford University Press. This book was released on 1996 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of papers on aspects of statistics in toxicology is will be of interest to all medical statisticians. It offers findings from numerous leading experts from around the world including A. Whitehead and R. N. Connor (University of Reading), L. Ryan (Harvard), A. P. Grieve (Pfizer Research), K.J. Risko (Northern Telecom), and B.H. Margolin (University of North Carolina). This is the latest in the popular Royal Statistical Society Lecture Series, and will be essential reading for all those involved in this area.

Download or read book Statistical Methods in Toxicology written by Ludwig Hothorn and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Download or read book ICRDB Cancergram written by and published by . This book was released on 1985 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biostatistics in the Study of Toxicology written by and published by . This book was released on 1994 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design and Analysis of Animal Studies in Pharmaceutical Development written by Shein-Chung Chow and published by CRC Press. This book was released on 1998-01-15 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examples. "

Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics Abstracts written by and published by . This book was released on 1999 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medical Applications of Finite Mixture Models written by Peter Schlattmann and published by Springer Science & Business Media. This book was released on 2009-03-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients are not alike! This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the “average” patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author’s point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known explanatory covariates. Finite mixture models may be used to aid this purpose. This book tries to show that there are a large range of applications. They include the analysis of gene - pression data, pharmacokinetics, toxicology, and the determinants of beta-carotene plasma levels. Other examples include disease clustering, data from psychophysi- ogy, and meta-analysis of published studies. The book is intended as a resource for those interested in applying these methods.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Statistical Methods in Cancer Research The design and analysis of long term animal experiments written by Norman E. Breslow and published by . This book was released on 1980 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Statistical Methods in Cancer Research written by and published by . This book was released on 1980 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses an area of cancer research that is of great importance in the understanding of carcinogenic risk factors: the development of measures to standardize methods for long-term tests based on a thorough treatment of the statistical issues that are involved. This area of research is particularly important due to the biological limitations of short-term assays and the methodological difficulties of some epidemiological studies.

Download or read book Encyclopedia of Quantitative Risk Analysis and Assessment written by and published by John Wiley & Sons. This book was released on 2008-09-02 with total page 2163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.

Download or read book IARC Scientific Publications written by and published by . This book was released on 1986 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Long term and Short term Assays for Carcinogens written by International Program on Chemical Safety and published by . This book was released on 1986 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers presented at a meeting held in December 1985 to review the conduct and use of long- and short- term assays for the detection of chemical carcinogens. The meeting was attended by about 60 experts in the fields of carcinogenesis, mutagenesis, and cell biology. The series of reports on long-term carcinogenicity assays pay particular attention to three topics: the role of pharmacokinetic data, early preneoplastic lesions in carcinogenesis, and the possibility for discerning the relative contribution of carcinogens to various stages of carcinogenesis. The reports on short-term assays summarize, among other points, the principle and scientific basis of each assay and its relevance to carcinogen detection and to the multistage process of carcinogenesis.

Download or read book Statistics in Toxicology Using R written by Ludwig A. Hothorn and published by CRC Press. This book was released on 2016-01-13 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi

Download or read book Computer Age Statistical Inference written by Bradley Efron and published by Cambridge University Press. This book was released on 2016-07-21 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The twenty-first century has seen a breathtaking expansion of statistical methodology, both in scope and in influence. 'Big data', 'data science', and 'machine learning' have become familiar terms in the news, as statistical methods are brought to bear upon the enormous data sets of modern science and commerce. How did we get here? And where are we going? This book takes us on an exhilarating journey through the revolution in data analysis following the introduction of electronic computation in the 1950s. Beginning with classical inferential theories - Bayesian, frequentist, Fisherian - individual chapters take up a series of influential topics: survival analysis, logistic regression, empirical Bayes, the jackknife and bootstrap, random forests, neural networks, Markov chain Monte Carlo, inference after model selection, and dozens more. The distinctly modern approach integrates methodology and algorithms with statistical inference. The book ends with speculation on the future direction of statistics and data science.