Download or read book A Melanotropic Peptide Induces Pigmentation Tanning of Human Skin written by M. E. Hadley and published by . This book was released on 1992 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have designed and biologically characterized an analog of alpha-melanocyte stimulating hormone with the following structure: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. The hormone analog is superpotent, prolonged acting and is resistant to inactivation by sera and proteolytic enzymes. This peptide stimulates various pigmentation in the mouse when administered topically or when injected subcutaneously. Following FDA and Human Subjects Committee approval, the peptide was delivered by subcutaneous injection to human volunteers in a phase-I clinical trial.
Download or read book Melanins and Melanogenesis written by Giuseppe Prota and published by Academic Press. This book was released on 2012-12-02 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of melanin pigmentation, providing a concise, comprehensive picture of new knowledge gained at the frontiers of research. It draws heavily on the author's 30-year activity in the field and his continuing work with specialists of widely diverse disciplines. The core of the volume deals with the structure, physicochemical properties, and biosynthesis of the major classes of melanin pigments, including neuromelanins. Further discussions include the biology of the various types of pigment-producing cells, the structure and mode of action of tyrosinase, and the chemistry of urinary melanogens and their biomedical applications as metabolic markers of melanocyte activity, especially for the follow-up of malignant melanoma. Finally, the volume considers progress in the photobiology and photochemistry of melanins, with special emphasis on the controversial role of these pigments in skin photoprotection. Melanins and Melanogenesis is ideally suited as a basic guide for newcomers, and a handy source of specific information for practitioners in academic, medical, and industrial settings.
Download or read book Sensing the Environment Regulation of Local and Global Homeostasis by the Skin s Neuroendocrine System written by Andrzej T. Slominski and published by Springer Science & Business Media. This book was released on 2012-06-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
Download or read book Peptides Chemistry and Biology written by J.A. Smith and published by Springer. This book was released on 1992-02-29 with total page 1058 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings of the Twelfth American Peptide Symposium include 363 articles which were selected for publication on the basis of originality, timeliness and scientific significance. This volume includes contributions on ppetide hormones, neuropeptides, lipid-interactive peptides, peptide and protein conformation, de novo design, structure-activity relationships, synthetic methods, large-scale peptide synthesis, viruses and vaccines, peptide mimetics, peptide inhibitors, immunology and new biologically active peptides.
Download or read book Pathophysiology of Dermatologic Diseases written by Nicholas A. Soter and published by McGraw-Hill Companies Health Professions Division. This book was released on 1991 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cosmeceuticals and Active Cosmetics written by Raja K Sivamani and published by CRC Press. This book was released on 2015-09-18 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmeceuticals and Active Cosmetics discusses the science of nearly two dozen cosmeceuticals used today. This third edition provides ample evidence on specific cosmeceutical substances, their classes of use, skin conditions for which they are used, and points of interest arising from other considerations, such as toxicology and manufacturing. The book discusses both cosmetic and therapeutic uses of cosmeceuticals for various conditions including rosacea, dry skin, alopecia, eczema, seborrheic dermatitis, purpura, and vitiligo. Active ingredients in the following products are discussed: caffeine, curcumin, green tea, Rhodiola rosea, milk thistle, and more. Also covered are topical peptides and proteins, amino acids and derivatives, antioxidants, vitamins E and C, niacinamide, botanical extracts, and biomarine actives. Providing ample scientific references, this book is an excellent guide to understanding the science behind the use of cosmeceuticals to treat a variety of dermatological conditions.
Download or read book Integration of Pharmaceutical Discovery and Development written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2006-01-19 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.
Download or read book Melanins and Melanosomes written by Jan Borovansky and published by John Wiley & Sons. This book was released on 2011-08-15 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.
Download or read book Neuroimmunology of the Skin written by Richard D. Granstein and published by Springer Science & Business Media. This book was released on 2009-02-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much anecdotal information has suggested an influence of psychology and the nervous system on immunity within the skin and the expression of inflammatory skin disorders. Recent years have seen an explosion of knowledge providing a scientific basis for important regulatory interactions between the nervous system, the endocrine system and the immune system within the skin. The results of recent investigations have important implications, not only for an understanding of cutaneous immunity, but also for the development of novel treatments for diseases involving abnormal inflammation or immune reactivity within the skin. This book provides a comprehensive and interdisciplinary review of the molecular biology, cell biology, biochemistry and clinical aspects of nervous system–immune system interactions within the skin. It includes contributions from leading world experts in these areas. The contents are relevant to both investigators and clinicians interested in the skin, its functions and its disorders.
Download or read book Science of Ashwagandha Preventive and Therapeutic Potentials written by Sunil C. Kaul and published by Springer. This book was released on 2017-09-13 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body's defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities.
Download or read book Insect Chemoreception written by M.F. Ryan and published by Springer Science & Business Media. This book was released on 2002-01-31 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume encompasses and unites all the major topics relating to Insect Chemoreception. Part 1 addresses topics such as plant/insect interactions, pheromones, ultrastructure, electrophysiology and the biochemistry of chemoreceptors. Part 2 embraces applications of plant chemicals and cultivars in insect pest control, host plant resistance and pheromones. A concluding chapter discusses the scope and potential of genetic engineering. This comprehensive account of the major aspects of sustainable insect pest control, together with the key references cited, will point the way to relevant research projects, and provide an up-to-date awareness of recent developments in the field. Audience: Graduate students and researchers in insect chemoreception, chemical ecology and sustainable pest control.
Download or read book The Pigmentary System written by James J. Nordlund and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 1248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive and integrated book on pigmentation The Pigmentary System, Second Edition, gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes. New features of this Second Edition include: Completely new section on the basic science of pigmentation – explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system New chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV All clinical chapters include the latest genetic findings and advances in therapy More than 400 color images of virtually all clinical disorders The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.
Download or read book Light Based Therapies for Skin of Color written by Elma Baron and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Light-based therapies have been a major component of dermatologic practice. Historically, these treatment modalities have been mainly tailored to the treatment of patients with light skin. Principles governing use of light therapies in skin of color are less defined. However, there is a tremendous need to understand the benefits and limitations of these therapeutic options for dark-skinned patients as well. Demographic data in the United States alone indicate that the population and recipients of health care are rapidly changing with regard to skin phototype. Physicians who are involved in the delivery of care for patients with cutaneous problems that can be addressed by light treatments need to be able to fully understand the mechanisms, applications, risks, efficacy, adverse events, and other pertinent issues in considering treatment options for their patients with pigmented skin.
Download or read book Clinical Endocrinology of Dogs and Cats written by A. Rijnberk and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical endocrinology is a fascinating field requiring the challenging combination of broad pathophysiological interest and specific expertise in the field of endocrinology, thereby occupying a common ground between biochemistry, physiology and clinical medicine. In the majority of cases the clinician's notion of the presence of an endocrine disease is largely based upon pattern recognition, in which physical changes play an important role. Therefore many color illustrations have been included throughout the text. In addition there are many full color graphs and illustrations of diagnostic imaging and pathology. With over 350 illustrations the book represents a richly illustrated text on the diseases of endocrine glands. For each gland there is an introductory section on the relevant morphology and physiology, followed by descriptions of the disorders of the gland. When endocrine diseases are quite different in dogs and cats, separate descriptions are given for these species. Protocols for function tests and emergency treatments are presented in the last chapters. Consequently the book provides the user with both comprehensive descriptions and quick references. The book has been written by leading clinicians in the field, with contributions from two biochemists, a radiologist and pathologist. As such a valuable textbook for veterinary students and practitioners has been compiled to fulfil the need for an up-to-date and complete book on endocrine diseases of dogs and cats.
Download or read book Herbal Cosmetics Ayurvedic Medicines EOU 3rd Revised Edition written by P. K. Chattopadhyay and published by NIIR PROJECT CONSULTANCY SERVICES. This book was released on 2013-02-07 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbal cosmetics have been into usage from time immemorial so has been the use of Ayurvedic medicines. Ayurveda which means the complete knowledge for long life has been very popular these days on account of its minimum or zero side effects with considerable power of curing. Similarly herbal cosmetics have been of great value because of the least harm they cause to the skin and the radiance they add to the skin. These days a number of beauty products that are using the herbal formulae and Ayurveda concepts have got lot of attention and have been witnessing a huge rise in demand not only nationally but on international arena. The charm of understanding herbal product is even you can use it by making certain combination at your home and get the benefits. These are economical and sure to provide alleviate the problems not only for skin but for long term health issues also. Herbal products combine the skills of specialists in chemistry, physics, biology, medicine and herbs. These are less likely to cause any damaging effect to health. Bath and beauty products use herbs for both their scents and therapeutic qualities. Herbal products are replacing the synthetics products because of its harsh nature. Herbal products are in huge demand in the developed world for health care for the reason that they are efficient, safe and have lesser side effects. The formulations based on herbs are safe and effective. To exploit the knowledge that has got the genesis in our country the book aims to provide you a comprehensive information on different types of herbal Cosmetics formulas. The contents of the book are: Analysis of Creams, Infra-Red Spectrophotometer In Cosmetic Analysis, Infra Red Spectrophotometer In Cosmetic Analysis, Analysis of Creams, Analysis of Shampoos, Lal Tooth Powder, Bath and Massage Oil, Sun Care/Skin Lightening Compound, Herbal Liver Tonic, Vicks Like Compound, hair oil, Eye Drops, Packaging Criteria for Cosmetics and Toiletries, Vicks Like Compound, Cosmetics for Elderly People, Cough Syrup, Colour in Cosmetics, Herbal Liver Tonic, Herbal Formulation, Medicinal Herbs as Cosmetics, Medicinal & Massage Oils, Herbal Cosmetic Cream for Dry Skin, Herbal Deodorant Roll On, Drug Standardization, Guide Lines on GMP, Premises and Equipment Requirements, Aloe Gel, Tablets and Capsule, Sandalwood Oil and Machinery Section. The Third Revised Edition of Herbal cosmetics and Ayurvedic medicines (EOU) also includes photographs of machinery and equipments with addresses of their manufacturers. The book in general will be beneficial for entrepreneurs, industrialists, project consultants, libraries and in general all those looking for detail information.
Download or read book Melanocortins written by Anna Catania and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago—way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.
Download or read book Cosmetic Formulation written by Heather A.E. Benson and published by CRC Press. This book was released on 2019-04-05 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects. Key Features: Covers cosmetic products/formulation from theory to practice Includes case studies to illustrate real-life formulation development and problem solving Offers a practical, user-friendly approach, relying on the work of recognized experts in the field Provides insights into the future directions in cosmetic product development Presents basic formulation, skin science, advanced formulation and cosmetic product development
