Download or read book A Mathematical Approach to Multilevel Multiscale Health Interventions written by Rodrick Wallace and published by World Scientific. This book was released on 2013 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule OC magic bulletOCO interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States OCo from $200 million in 1950 to $1.2 billion in 2010 OCo has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of OC magic bulletsOCO, we must now apply OC magic strategiesOCO that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies."

Download or read book Mathematical Approach To Multilevel Multiscale Health Interventions A Pharmaceutical Industry Decline And Policy Response written by Rodrick Wallace and published by World Scientific. This book was released on 2013-01-28 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies./a

Download or read book Computational Psychiatry written by Rodrick Wallace and published by Springer. This book was released on 2017-04-20 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

Download or read book Introducing the Oscillations Based Paradigm written by Darius Plikynas and published by Springer. This book was released on 2016-06-16 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a conceptually novel oscillations based paradigm, the Oscillation-Based Multi-Agent System (OSIMAS), aimed at the modelling of agents and their systems as coherent, stylized, neurodynamic processes. This paradigm links emerging research domains via coherent neurodynamic oscillation based representations of the individual human mind and society (as a coherent collective mind) states. Thus, this multidisciplinary paradigm delivers an empirical and simulation research framework that provides a new way of modelling the complex dynamics of individual and collective mind states. This book addresses a conceptual problem – the lack of a multidisciplinary, connecting paradigm, which could link fragmented research in the fields of neuroscience, artificial intelligence (AI), multi-agent system (MAS) and the social network domains. The need for a common multidisciplinary research framework essentially arises because these fields share a common object of investigation and simulation, i.e., individual and collective human behavior. Although the fields of research mentioned above all approach this from different perspectives, their common object of investigation unites them. By putting the various pathways of research as they are interrelated into perspective, this book provides a philosophical underpinning, experimental background and modelling tools that the author anticipates will reveal new frontiers in multidisciplinary research. Fundamental investigation of the implicit oscillatory nature of agents’ mind states and social mediums in general can reveal some new ways of understanding the periodic and nonperiodic fluctuations taking place in real life. For example, via agent states-related diffusion properties, we could investigate complex economic phenomena like the spread of stock market crashes, currency crises, speculative oscillations (bubbles and crashes), social unrest, recessionary effects, sovereign defaults, etc. All these effects are closely associated with social fragility, which follows and is affected by cycles such as production, political, business and financial. Thus, the multidisciplinary OSIMAS paradigm can yield new knowledge and research perspectives, allowing for a better understanding of social agents and their social organization principles.

Download or read book Gene Expression and Its Discontents written by Rodrick Wallace and published by Springer. This book was released on 2016-11-23 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Download or read book Genes Brains and Human Potential written by Ken Richardson and published by Columbia University Press. This book was released on 2017-03-21 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: For countless generations people have been told that their potential as humans is limited and fundamentally unequal. The social order, they have been assured, is arranged by powers beyond their control. More recently the appeal has been to biology, specifically the genes, brain sciences, the concept of intelligence, and powerful new technologies. Reinforced through the authority of science and a growing belief in bio-determinism, the ordering of the many for the benefit of a few has become more entrenched. Yet scientists are now waking up to the influence of ideology on research and its interpretation. In Genes, Brains, and Human Potential, Ken Richardson illustrates how the ideology of human intelligence has infiltrated genetics, brain sciences, and psychology, flourishing in the vagueness of basic concepts, a shallow nature-versus-nurture debate, and the overhyped claims of reductionists. He shows how ideology, more than pure science, has come to dominate our institutions, especially education, encouraging fatalism about the development of human intelligence among individuals and societies. Genes, Brains, and Human Potential goes much further: building on work being done in molecular biology, epigenetics, dynamical systems, evolution theory, and complexity theory, it maps a fresh understanding of intelligence and the development of human potential. Concluding with an upbeat message for human possibilities, this synthesis of diverse perspectives will engender new conversations among students, researchers, and other interested readers.

Download or read book Systems Optimization Methodology written by V. V. Kolbin and published by World Scientific. This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph defines the notion of a ?system? by reference to those systems which exhibit goal-oriented behavior and utilize the notion of decision making and controls. Such systems allow for phenomenological description and fix the nature of causal transformations of input effects into output quantities. The study of consequences of the fact that the systems possess some properties constitutes the content of systems optimization methodology which goes beyond the scope of descriptive classification of systems.Chapter 1 deals with philosophical problems of systems methodology. An attempt is made to systematize and analyze the problems of scientific methodology as applied to systems modeling methodology which is viewed as the most general concept utilized in modern science.Chapter 2 focuses on problems of qualitative analysis in natural and social sciences. Attention is drawn to problems of measurement theory and quantitative analysis of systems.Approaches and methods of systems analysis and synthesis form the central portion of the book. Much study is given to the methods of systems decomposition, an integration using both discrete and continuous descriptions of objects, processes, and phenomena. Examples of complex goal-oriented systems are also provided.The remaining part of the book is largely centered around the methodology of multiobjective systems optimization.

Download or read book Multiscale Problems Theory Numerical Approximation And Applications written by Alain Damlamian and published by World Scientific. This book was released on 2011-10-13 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this is on the latest developments related to the analysis of problems in which several scales are presented. After a theoretical presentation of the theory of homogenization in the periodic case, the other contributions address a wide range of applications in the fields of elasticity (asymptotic behavior of nonlinear elastic thin structures, modeling of junction of a periodic family of rods with a plate) and fluid mechanics (stationary Navier-Stokes equations in porous media). Other applications concern the modeling of new composites (electromagnetic and piezoelectric materials) and imperfect transmission problems. A detailed approach of numerical finite element methods is also investigated.

Download or read book The Mathematical Theory of Nonblocking Switching Networks written by Frank Hwang and published by World Scientific. This book was released on 2004 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this book was the first to cover in depth the mathematical theory of nonblocking multistage interconnecting networks, which is applicable to both communication and computer networks. This comprehensively updated new edition not only introduces the classical theory of the fundamental point-to-point network but also has a renewed emphasis on the latest multicast and multirate networks. The book can serve as either a one- or two-semester textbook for graduate students of information science, (electronic) communications, and applied mathematics. In addition, as all the relevant literature is organized and evaluated under one structured framework, the volume is an essential reference for researchers in those areas.

Download or read book A First Course in Integral Equations written by Abdul-Majid Wazwaz and published by World Scientific. This book was released on 1997 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the subject of integral equations in an accessible manner for a variety of applications. Emphasis is placed on understanding the subject while avoiding the abstract and compact theorems. A distinctive feature of the book is that it introduces the recent powerful and reliable developments in this field, which are not covered in traditional texts. The newly developed decomposition method, the series solution method and the direct computation method are thoroughly implemented, which allows the topic to be far more accessible. The book also includes some of the traditional techniques for comparison.Using the newly developed methods, the author successfully handles Fredholm and Volterra integral equations, singular integral equations, integro-differential equations and nonlinear integral equations, with promising results for linear and nonlinear models. Many examples are given to introduce the material in a clear and thorough fashion. In addition, many exercises are provided to build confidence, ease and skill in using the new methods.This book may be used as a text for advanced undergraduates and graduate students in mathematics and scientific areas, and as a work of reference for research study of differential equations and numerical analysis.

Download or read book Fractional Calculus And Waves In Linear Viscoelasticity An Introduction To Mathematical Models written by Francesco Mainardi and published by World Scientific. This book was released on 2010-05-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph provides a comprehensive overview of the author's work on the fields of fractional calculus and waves in linear viscoelastic media, which includes his pioneering contributions on the applications of special functions of the Mittag-Leffler and Wright types.It is intended to serve as a general introduction to the above-mentioned areas of mathematical modeling. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary background material needed to delve further into the subject and explore the research literature given in the huge general bibliography.This book is likely to be of interest to applied scientists and engineers./a

Download or read book The Method Of Maximum Entropy written by Henryk Gzyl and published by World Scientific. This book was released on 1995-03-16 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is an outgrowth of a set of lecture notes on the maximum entropy method delivered at the 1st Venezuelan School of Mathematics. This yearly event aims at acquainting graduate students and university teachers with the trends, techniques and open problems of current interest. In this book the author reviews several versions of the maximum entropy method and makes its underlying philosophy clear.

Download or read book Modelling in Healthcare written by and published by American Mathematical Soc.. This book was released on 2010 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: A model is a simplified representation of a real-world situation used to help answer a specific question. This book provides a look into the world of modelling with the focus on modelling in healthcare.--[from preface]

Download or read book Frontiers And Prospects Of Contemporary Applied Mathematics written by Pingwen Zhang and published by World Scientific. This book was released on 2006-04-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of articles covers the hottest topics in contemporary applied mathematics. Multiscale modeling, material computing, symplectic methods, parallel computing, mathematical biology, applied differential equations and engineering computing problems are all included. The book contains the latest results of many leading scientists and provides a window on new trends in research in the field.

Download or read book The Mathematical Nature of the Living World written by Gilbert Chauvet and published by World Scientific. This book was released on 2005 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of the book a theory of functional biology thatincorporates the fundamental principles underlying the functioning ofliving organisms is clearly appropriate as we celebrate the 50thanniversary of the discovery by Watson and Crick of the structure ofthe DNA molecule.

Download or read book Descriptive and Normative Approaches to Human Behavior written by Ehtibar N. Dzhafarov and published by World Scientific. This book was released on 2012 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to present side-by-side representative and cutting-edge samples of work in mathematical psychology and the analytic philosophy with prominent use of mathematical formalisms.

Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline