Download or read book A hypothesis that proposes that defects in PHD2 and PHD3 function may be causal of the symptoms of schizopnrenia written by John Neville and published by Lulu.com. This book was released on 2019-09-08 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: A defect in the coactivation of HIF1 by PKM2 and PHD3 has been implicated in a familial disorder which can cause autoinflammatory symptoms, connective tissue symptoms and psychosis. It has also been pointed out that a majority of predicted target genes of HIF1 are associated with schizopnrenia, or have altered function or expression in schizopnrenia. PHD2 and PHD3 both regulate HIF1a. Here it is noted that PHD2 (EGLN1) is located at 1q42.2, very close to the location of DISC1 and DISC2, whilst PHD3 (EGLN3) is located at 14q13.1, very close to the location of NPAS3. The disruption of DISC1 and DISC2 genes by a translocation co-segregating with familial schizopnrenia is well known. A mutation in NPAS3 also segregates with schizophrenia in a small family. This raises the interesting possibility that defective PHD2 and PHD3 function could be causal of the symptoms of schizopnrenia.
Download or read book Paragangliomas and schizophrenia linked to EGLN1 EGLN2 EGLN3 and DISC1 function written by John Neville and published by Lulu.com. This book was released on 2019-10-05 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previously evidence was considered which raised the interesting possibility that defective EGLN1 and EGLN3 function could be causal of the symptoms of schizopnrenia. Here it is pointed out that EGLN1, EGLN2, EGLN3, DISC1 are either functional for or strongly associated with paragangliomas, which are well known to cause anxiety and panic, but which can also cause psychosis which can remit with removal of the tumour. This raises various questions of importance which may well lead to the identifying of biomarkers for one of the causes of psychosis and novel treatments.
Download or read book EGLN1 EGLN2 EGLN3 inhibitors as possible treatments for psychotic disorders schizopnrenia associated with Parkinson s disease written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Flanking schizopnrenia evidence pointing to EGLN genes as well as RPS27 and RPL7 and RPL23 genes playing a central role in schizopnrenia pathogenesis written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EGLN3 as a candidate location for a familial disorder which can cause anxiety panic insomnia psychosis and physical symptoms of autoinflammatory disorders and connective tissue disorders written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EGLN1 EGLN2 EGLN3 inhibitors as possible treatments for psychotic disorders schizopnrenia written by John Neville and published by Lulu.com. This book was released on 2019-11-12 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was previously proposed that defective EGLN1 and EGLN3 function could be causal of the symptoms of schizopnrenia in a familial disorder where psychosis can be a comorbidity and more generally. Here it is pointed out that EGLN1, EGLN2, EGLN3 inhibitors are being trialed in the treatment of anemia. It is recalled that in the familial disorder mentioned above, the proband had mild indications of anemia when acutely ill, whilst the proband's father had anemia. Since anemia can be a comorbidity in schizopnrenia, here it is proposed that psychotic disorder/schizophrenic patients with mild indications of anemia may be responsive to EGLN1, 2 and 3 inhibitors. It is proposed that a trial of EGLN1, 2 and 3 inhibitors as a treatment for psychotic disorder/schizopnrenia where anemia is a comorbidity could be worthwhile.
Download or read book EGLN3 ADRB AFAP and ABLIM and their possible central and perhaps causal role in anxiety disorders written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EGLN3 keratin and Morganelles Disorder and their possible roles in the pathogenesis of Borderline Personality Disorder Bipolar Disorder schizopnrenia and anxiety written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychotic Disorders written by Carol A. Tamminga MD and published by Oxford University Press. This book was released on 2020-10-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis--one of the most fascinating manifestations of altered brain behavior--that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.
Download or read book Pathophysiology written by Kathryn L. McCance, RN, PhD and published by Elsevier Health Sciences. This book was released on 2014-01-14 with total page 1908 pages. Available in PDF, EPUB and Kindle. Book excerpt: With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What's New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available! Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text. A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Chapter summary reviews provide concise synopses of the main points of each chapter. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. EXTENSIVELY Updated content reflects advances in pathophysiology including tumor biology invasion and metastases, the epidemiology of cancer, diabetes mellitus, insulin resistance, thyroid and adrenal gland disorders, female reproductive disorders including benign breast diseases and breast cancer, and a separate chapter on male reproductive disorders and cancer. NEW! Chapter on epigenetics and disease. Additional What's New boxes highlight the most current research and clinical development.
Download or read book Fast Facts for Psychopharmacology for Nurse Practitioners written by Deana Shevit Goldin, PhD, DNP, APRN, FNP-BC, PMHNP-BC and published by Springer Publishing Company. This book was released on 2022-11-01 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely resource is the first handbook to give nurse practitioners guidance to prescribe, monitor, assess, educate, and advocate for patients taking psychiatric medications and promote safe practice outcomes. Written in a concise, bulleted style for quick access to critical information, this practical resource covers the key aspects of psychotropic medications used in general psychiatry, offers strategies to simplify medication decision-making, and provides evidence-based best practice recommendations to select and manage psychotropic medications. This resource begins with an overview of general pharmacological principles, a brief discussion of neurotransmitters, and covers rationale for medication use and the risks and benefits of the major classes of psychotropic medications. This is followed by information about common drugs across drug classes divided by age population. Each drug includes initial dosing and adjustments, simplified diagnostic criteria, practice management, rationale for use, black box warnings, drug interactions, identification of side effects and adverse reactions, basic lab test recommendations, treatment options, and self-management strategies. The book ends with important concepts for patient and/or caregiver education and advocacy. Tables and "Fast Facts" boxes throughout highlight key information. Chapters begin with learning objectives and include references, website resources, and recommendations for additional reading. Key Features: Follows a lifespan approach to psychiatric mental health pharmacology Provides population-specific treatment approaches for optimal medical decision-making Highlights critical information with "Fast Facts" boxes Delivers essential knowledge included in board certification exams Contains critical-thinking questions in each chapter to reinforce content
Download or read book Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia Regional cerebral blood flow evidence written by Daniel Roy Weinberger and published by . This book was released on 1986 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurodevelopment and Schizophrenia written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 2004-11-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book The British Journal of Psychiatry written by and published by . This book was released on 1989 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cognitive Impairment in Schizophrenia written by Philip D. Harvey and published by Cambridge University Press. This book was released on 2013-01-24 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Download or read book Network Neuroscience written by Flavio Fröhlich and published by Academic Press. This book was released on 2016-09-20 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader's background. Dr. Flavio Frohlich wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology. - Easy-to-read, comprehensive introduction to the emerging field of network neuroscience - Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism - Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics
