Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Combined Toxic Gas Modeling Phase 4 Blood Chemistry Model Validation written by and published by . This book was released on 1999 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: There currently is no adequate model to assess the toxicity of combined toxic gasses in acute concentrations. To address these shortcomings, a multicompartment model describing the relevant physiological and chemical processes is proposed. The model has been integrated in a stable, accurate computational procedure that rigorously conserves mass and has spatial and temporal numerical convergence. The results of this integrated transport and chemistry model have been compared favorably with experimental data on carbon monoxide exposure in rat and man.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Biological Response to Blast Overpressure A Summary of Modeling written by and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A soldier in training is exposed to a variety of blast sources that can adversely affect his auditory and nonauditory systems. While auditory standards have been formulated for many decades, knowledge about nonauditory effects of blast have not been captured in a criteria that can be applied to all circumstances. For the past 15 years, JAYCOR, working together with the Walter Reed Army Institute of Research, has been using modeling, simulation, and data analysis to determine the nature of injury in animal models, capture that understanding in physiologically correct mathematical models, and extend the findings to objective criteria that can be used to set exposure limits. This paper summarizes the accomplishments of that effort.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Analysis of RFR Biological Effects written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The avoidance of harmful effects, especially long term effects (cancers, mutations, reproductive disorders, etc.) is one of the dominant concerns for nonlethal weapons generally, and RFR technologies specifically. The need for the participation of policy, legal, and medical organizations at all stages of the research means that familiarity with the scientific basis for the potential occurrence of these effects is critical. All of these organizations recognize that the first step in this assessment is a review of the literature. In order to provide some guidance in this area, a summary of existing, reviewed literature was made. Several comprehensive reviews of the RFR biological effects research have been conducted in the past two years and these reviews provided the basis for this analysis. Our objective is not to make a scholarly assessment of the research, but to analyze trends in the data, as reported.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Citation Database Version 1 written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This database contains a comprehensive list of citations that were generated by the Blast Overpressure Program (BOP), Kirtland Air Force Base, New Mexico, from 1951 through 1998. The database was created using Microsoft Access97. The purpose and use of this database is two-fold: 1. To compile a comprehensive bibliography of the documents generated by the researchers at the BOP from 1951 through 1998, and 2. To create a database in a form wherein information could be easily retrieved by a multitude of identifiers, for example, if an individual were interested in only retrieving the documents that used the rat for a model, exposed to a Friedlander wave, single exposure, high explosives, with primary blast as the target injury at a threshold level. A hard-copy is provide & Section I contains a copy of the database sorted alphabetically by author. Section II contains a copy of the database sorted alphabetically by title. Section III is sorted numerically and includes the abstracts of each citation. Finally, Section Iv contains a copy of the Animal Information Report.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Blast Overpressure Research Program written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of nuclear blast caused a renewed interest in blast research in the United States. Thus, was the beginning of the Blast Overpressure Program at Kirtland Air Force Base, New Mexico. From the early 1950's through 1997, research on the biomedical, biological and biophysical effects of blast and shock was conducted. During this time, data essential to the understanding of the broad and complex nature of the biological effects of blast overpressure and impulse noise were obtained.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle Use of Animal Test Data in the Development of a Human Auditory Hazard Criterion for Impulse Noise written by and published by . This book was released on 1998 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hearing loss and sensory cell loss data, obtained from 909 chinchillas exposed to one of 137 different impulse noise or blast wave exposure paradigms, were statistically analyzed. The objective was to extract relations between the effects of the exposure on the auditory system (effects metrics) and metrics used to characterize the blast wave exposure. Specifically the following two questions were asked: (a) What is the best indicator of the amount of hazard associated with an impulse noise exposure? (b) How does the hazard of an impulse noise exposure accumulate with increasing numbers of impulses? Two analytical approaches were used. Both approaches indicated that the P-weighting functions or one of its derivatives (P1-, P2- or R-weighting) best organized the effects metrics. Depending on the analytical approach, either an energy trading rule of 10 log10 N or 6 log10 N; where N is the number of impulses, best organized the data for N between 10 and 100. For exposures of between 1 and 10 impulses, a region of the parametric space that is of considerable practical significance, there is insufficient data to form any conclusions. For this region the limited data suggest that an energy trading rule i.e., 10 log N, does not work.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures Subtitle NLT Bioeffects Broad Issue Study written by and published by . This book was released on 1997 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the United States becomes more of a peace broker, its military forces must have the appropriate equipment and training to bring peace to unstable regions. Consequently, the Department of Defense has devoted significant resources to developing weapons that apply an appropriate force against an adversary in order to subdue or repel him, without maiming or killing the intended target or innocent bystanders. The application of these nonlethal weapon (NLW) systems in world hot-spots has the potential to significantly reduce collateral damage, conflict escalation and enemy fatalities, while keeping friendly forces secure. US military and law enforcement agencies are interested in acquiring and technology organizations are interested in developing effective weapons. There are, however, significant questions about the nature of the biological effects that are caused and the amount of harmful effects that can be tolerated by such systems.
Download or read book Die Chemotherapie der Tuberkulose written by and published by . This book was released on 1983 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Health Hazard Assessment for Blast Overpressure Exposures written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report describes the status of research to develop a biomechanically-based health hazard assessment for blast overpressure.
Download or read book A Health Hazard Assessment for Blast Overpressure Exposure written by and published by . This book was released on 2002 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report describes progress toward understanding and quantifying injury arising from impact or impulsive loading to the body from blast, projectiles, or vehicle restraint systems.
Download or read book Health Hazards Assessment for Blast Overpressure Exposures written by and published by . This book was released on 1994 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Army needs to set blast overpressure exposure standards that will protect soldiers in training against adverse effects from blast coming from a variety of weapons in a variety of surroundings. JAYCOR is developing biomechanical models that compute the tissues level response due to external blast loading and correlations of that response to pathology and lethality. To validate the models, animal test data has been organized into a database. Trends in the data have been determined that are independent of the models and agreement between the correlations and observations have been good for all level of blasts and animal species. The future work will refine the pathology prediction by location and provide a probabilistically-based methodology for making health hazards assessment.
Download or read book Human Variability in Response to Chemical Exposures Measures Modeling and Risk Assessment written by David A. Eckerman and published by CRC Press. This book was released on 1998-08-25 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Download or read book Principles of Characterizing and Applying Human Exposure Models written by International Program on Chemical Safety and published by World Health Organization. This book was released on 2005 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this manual is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose and concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix, and a glossary of terms is also provided.--Publisher's description.
Download or read book Hazardous Gases written by Jaspal Singh and published by Academic Press. This book was released on 2021-07-17 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hazardous Gases: Risk Assessment on Environment and Human Health examines all relevant routes of exposure, inhalation, skin absorption and ingestion, and control measures of specifics hazardous gases resulting from workplace exposure from industrial processes, traffic fumes, and the degradation of waste materials and how they impacts the health and environment of workers. The book examines the risk assessment and effect of poisonous gases on the environment human health. It also covers necessary emergency guidelines, safety measures, physiological impact, hazard control measures, handling and storage of hazardous gases. Each chapter is formatted to include an introduction, historical background, physicochemical properties, physiological role discussing mechanisms of toxicity, its effect on human health as well as environment, followed by case studies and recent research on toxic gases. Hazardous Gases: Risk Assessment on Environment and Human Health is a helpful resource for academics and researchers in toxicology, occupational health and safety, and environmental sciences as well as those in the field who work to assess and mitigate the impact of toxic gases on the work environment and the health of the workforce. - Emphasizes the environmental monitoring in the workplace of hazardous materials - Includes all relevant storage and handling information required for detailing all personnel on the hazards and risks from the substances with which they work - Offers practical examples and case studies related to toxic gases and their impact on health
Download or read book Fires Explosions and Toxic Gas Dispersions written by Marc J. Assael and published by CRC Press. This book was released on 2010-02-23 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's risk analysis is a very challenging field, and a solid understanding of the calculations procedure associated with it is essential for anyone involved. Fires, Explosions, and Toxic Gas Dispersions: Effects Calculation and Risk Analysis provides an overview of the methods used to assess the risk of fires, explosions, and toxic gas dispersion
Download or read book Principles for Modelling Dose response for the Risk Assessment of Chemicals written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
Download or read book Human Variability in Response to Chemical Exposures Measures Modeling and Risk Assessment written by David A. Neumann and published by CRC Press. This book was released on 1998-08-25 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
