Download or read book A Handheld 3D Bioprinter for in Situ Tissue Regeneration written by Anton Hjaltason and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the field of tissue engineering, three-dimensional (3D) bioprinting has emerged as a novel approach to make hydrogel scaffolds in situ with a variety of shapes and sizes. This method involves the extrusion of cells and biomaterials in filaments, enabling layer-by-layer scaffold deposition, followed by photo-mediated crosslinking. Its versatility makes it uniquely suited for personalized tissue regeneration, where patient-specific hydrogel scaffolds may be applied to wound areas with irregular shapes. One caveat of current 3D bioprinters on the market is that they are typically desktop systems. While these devices can fabricate many scaffold shapes with high fidelity, it is difficult for the computer system to exactly match the complex geometries seen in many wounds. Handheld 3D bioprinters can resolve this issue by directly depositing bioinks onto an area of the body. Handheld bioprinters currently exist on the market and in the laboratory, but many are unergonomic, require bulky external equipment, or lack specific flow rate control. This project involves the design and testing of a new handheld 3D bioprinter that can print a gelatin methacryloyl (GelMA)-based granular bioink in situ. Granular bioinks have been developed to solve the challenge of nanoporous bulk hydrogels by taking advantage of the void space among microscale hydrogel particles (microgels). These microgels can be mixed with nanoparticles and a photoinitiator to make a nanoengineered granular bioink, NGB, which is then 3D bioprinted into a scaffold. The design of the handheld bioprinter developed in this project includes a mechanical piston extrusion system, specific flow rate control, and a small form factor. The goal of these experiments is to combine the technology of handheld 3D bioprinting with NGB to bring this new bioink into surgical settings in the future. The results indicate that the handheld bioprinter is simple and inexpensive to manufacture. Additionally, it can print NGB somewhat effectively and shows promise for future experiments with the granular bioink.

Download or read book 3D Bioprinting in Tissue and Organ Regeneration written by Yang Wu and published by Academic Press. This book was released on 2022-09-10 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting in Tissue and Organ Regeneration covers state-of-the-art advances and applications in bioprinting. Beginning with an introduction that considers techniques, bioinks and construct design, the authors then move onto a detailed review of applications of bioprinting in different biomedical fields (skin, cartilage, bone, vascularized tissue, etc.). This is followed by a chapter overview of intraoperative bioprinting, which is widely considered one of the important future trends in this area. Finally, the authors tackle ethical and regulation concerns regarding the utilization of bioprinting.The book is written by three global experts for an audience of students and professionals with some basic knowledge of bioprinting, but who seek a deeper understanding of the biomedical applications involved in bioprinting. - Introduces readers to bioprinting modalities, as well as pre-bioprinting, bioprinting and post-bioprinting procedures - Focuses on biomedical applications used in bioprinting in chapters specific to skin, cartilage, bone and vascularized tissue - Provides readers with original ideas from engineering and clinical points-of-view that are based on the authors' extensive experience in this field, as well as the possibilities of future translation of bioprinting technologies from bench to bedside

Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. - Explores the body's ability to mobilize endogenous stem cells to the site of injury - Details the latest strategies developed for inducing and supporting the body's own regenerating capacity - Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume - Features chapter authors and editors who are authorities in this emerging field - Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Download or read book 3D Bioprinting from Lab to Industry written by Prosenjit Saha and published by John Wiley & Sons. This book was released on 2024-07-04 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete overview of bioprinting, from fundamentals and essential topics to recent advances and future applications Additive manufacturing, also known as 3D printing, is one of the most transformative technological processes to emerge in recent decades. Its layer-by-layer construction method can create objects to remarkably precise specifications with minimal waste or energy consumption. Bioprinting, a related process that employs cells and biomaterials instead of man-made substances or industrial materials, has a range of biomedical and chemical uses that make it an exciting and fast-growing area of research. 3D Bioprinting from Lab to Industry offers a cutting-edge overview of this topic, its recent advances, and its future applications. Taking an interdisciplinary approach to a flourishing research field, this book exceeds all existing treatments of the subject in its scope and comprehensiveness. Moving from fundamental principles of the technology to its immense future potential, this is a must-own volume for scientists looking to incorporate this process into their research or product development. 3D Bioprinting from Lab to Industry readers will also find: Treatment of printing parameters, surface topography requirements, and much more Detailed discussion of topics including 5D printing in the medical field, dynamic tuning, the multi-material extrusion approach, and many others A complete account of the bioprinting process, from lab requirements to commercialization 3D Bioprinting from Lab to Industry is ideal for researchers—graduate and post-doctoral scholars—in the areas of materials science, biomedical engineering, chemical engineering, biotechnology, and biochemistry.

Download or read book 3D Bioprinting in Medicine written by Murat Guvendiren and published by Springer. This book was released on 2019-08-02 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.

Download or read book Design and Manufacturing written by Evren Yasa and published by BoD – Books on Demand. This book was released on 2020-07-29 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: In product development, decisions taken in design and manufacturing are considered the most influential factors for succeeding commercialisation. Product development is a complex integrated process of several steps starting from design where the market needs are identified and turned into competitive product specifications and different design concepts. In other words, design is about identifying a problem, developing solution proposals, and validating the most feasible solution with real users. Manufacturing technologies, on the other hand, help designers to make those virtual models into physical parts by transforming different types of raw materials. This book on design and manufacturing, written by a number of experts from all over the world, presents a design perspective and different manufacturing applications from various industrial sectors.

Download or read book Engineering Materials for Stem Cell Regeneration written by Faheem A. Sheikh and published by Springer Nature. This book was released on 2021-10-23 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation. It also elucidates the properties of stem cells, their characteristic features, tissue culture technology, properties of pluripotency, osteogenesis, and biomaterial interaction with de-cellularized organs, cell lineage in vivo and in vitro, gene expression, embryonic development, and cell differentiation. Further, the book reviews the latest applications of bio-instructive scaffold for supporting stem cell differentiation and tissue regeneration. The book also presents stem cell for dental, alveolar bone and cardiac regeneration. Lastly, it introduces engineered stem cells for delivering small molecule therapeutics and their potential biomedical applications.

Download or read book Frontiers in Tissue Engineering written by C.W. Patrick and published by Elsevier. This book was released on 1998-02-20 with total page 717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field. The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.

Download or read book 3D Printing and Biofabrication written by Aleksandr Ovsianikov and published by Springer. This book was released on 2018-06-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.

Download or read book 3D Printing in Medicine written by Deepak M. Kalaskar and published by Woodhead Publishing. This book was released on 2022-10-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand. - Reviews a broad range of biomedical applications of 3D printing biomaterials and technologies - Provides an interdisciplinary look at 3D printing in medicine, bridging the gap between engineering and clinical fields - Includes completely updated content with additional new chapters, covering topics such as organs-on-chips, bioprinting regulations, intellectual properties, medical standards in 3D printing, and more

Download or read book 3D Bioprinting written by Jeremy M. Crook and published by Springer Nature. This book was released on 2020-03-23 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest developments and contributions to the field of 3D bioprinting, and discusses its use for quality R&D and translation. The chapters in this book are divided into two parts: Part one covers generic themes in bioprinting to introduce novice readers to the field, while also providing experts with new and helpful information. Part two discusses protocols used to prepare, characterize, and print a variety of biomaterials, cells, and tissues. These chapters also emphasize methods used for printing defined and humanized constructs suitable for human tissue modelling in research and applicable to clinical product development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, 3D Bioprinting: Methods and Protocols is a valuable resource for researchers and bioprinting laboratories/facilities interested in learning more about this rapidly evolving technology.

Download or read book 3D Bioprinting for Reconstructive Surgery written by Daniel J. Thomas and published by Woodhead Publishing. This book was released on 2017-11-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting for Reconstructive Surgery: Techniques and Applications examines the combined use of materials, procedures and tools necessary for creating structural tissue constructs for reconstructive purposes. Offering a broad analysis of the field, the first set of chapters review the range of biomaterials which can be used to create 3D-printed tissue constructs. Part Two looks at the techniques needed to prepare biomaterials and biological materials for 3D printing, while the final set of chapters examines application-specific examples of tissues formed from 3D printed biomaterials. 3D printing of biomaterials for tissue engineering applications is becoming increasingly popular due to its ability to offer unique, patient-specific parts—on demand—at a relatively low cost. This book is a valuable resource for biomaterials scientists, biomedical engineers, practitioners and students wishing to broaden their knowledge in the allied field. - Discusses new possibilities in tissue engineering with 3D printing - Presents a comprehensive coverage of the materials, techniques and tools needed for producing bioprinted tissues - Reviews emerging technologies in addition to commercial techniques

Download or read book 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine written by Lijie Grace Zhang and published by Academic Press. This book was released on 2022-02-18 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions. The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration. - Includes clinical applications, regulatory hurdles, and a risk-benefit analysis of each technology - Assists readers in selecting the best materials and how to identify the right parameters for printing - Includes the advantages of integrating 3D printing and nanotechnology in order to improve the safety of nano-scale materials for biomedical applications

Download or read book Organ Manufacturing written by Xiaohong Wang and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first time that human organs, such as the heart, liver, kidney, stomach, uterus, skin, lung, pancreas and breast can be manufactured automatically and precisely for clinical transplantation, drug screening and metabolism model establishment. Headed by Professor Xiaohong Wang (also the founder and director) in the Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, this group has focused on organ manufacturing for over ten years. A series of technical bottleneck problems, such as vascular and nerve system establishment in a construct, multiple cell types and material system incorporation, and stem cell sequential engagement, have been overcome one by one. Two technical approaches have been exploited extensively. One is multiple nozzle rapid prototyping (RP), additive manufacturing (AM), or three-dimension (3D) printing. The other is combined mold systems. More than 110 articles and 40 patents with a series of theories and practices have been published consequently. In the future, all the failed organs (including the brain) in the human body can be substituted easily like a small accessory part in a car. Everyone can get benefit from these techniques, which ultimately means that the lifespan of humans, therefore, can be greatly prolonged from this time point. This book examines the progress made in the field and the developments made by these researchers (and authors) in the field.

Download or read book 3D Printing and Bioprinting for Pharmaceutical and Medical Applications written by Jose Luis Pedraz Muñoz and published by CRC Press. This book was released on 2023-09-27 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D Printing and Bioprinting for Pharmaceutical and Medical Applications discusses emerging approaches related to these game-changer technologies in such areas as drug development, medical devices, and bioreactors. Key Features: Offers an overview of applications, the market, and regulatory analysis Analyzes market research of 3D printing and bioprinting technologies Reviews 3D printing of novel pharmaceutical dosage forms for personalized therapies and for medical devices, as well as the benefits of 3D printing for training purposes Covers 3D bioprinting technology, including the design of polymers and decellularized matrices for bio-inks development, elaboration of 3D models for drug evaluation, and 3D bioprinting for musculoskeletal, cardiovascular, central nervous system, ocular, and skin applications Provides risk-benefit analysis of each application Highlights bioreactors, regulatory aspects, frontiers, and challenges This book serves as an ideal reference for students, researchers, and professionals in materials science, bioengineering, the medical industry, and healthcare.

Download or read book Articular Cartilage Tissue Engineering written by Kyriacos A. Athanasiou and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Download or read book 1568 1579 written by Scotland. Court of Exchequer and published by . This book was released on 1899 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: