Download or read book A Genetic Analysis of Ommatidial Planar Polarity Determination During the Development of the Drosophila Compound Eye written by Chung-Hui Yang (Neurobiology professor) and published by . This book was released on 2002 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book A Genetic Analysis of Retinal Development in Drosophila Melanogaster written by David Landreth Van Vactor and published by . This book was released on 1991 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Roles of Drosophila Genes TF11A S and F125 During Compound Eye Development written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drosophila compound eye represents an experimental system in which developmental decisions can be observed at a single-cell resolution. During larval development undifferentiated cells are sequentially recruited to form the individual subunits of the eye via cell-cell interactions which require Ras pathway activity.In this thesis I present the characterisation of two genes which play a part in eye development which were identified as part of the analysis of an enhancer detector P- element insertion. These are the small subunit of the basal transcription factor IIA (dTFIIA-S) and F125.dTFIIA-S was cloned and is transiently expressed in photoreceptor cells during their determination. Mutations generated in this locus are homozygous cellular lethal. However, a putative hypomorphic allele disrupts ommatidial assembly and eye development. In addition, these mutations act as dominant second-site suppressers of the rough eye phenotype caused by ectopic activation of the Ras pathway in eye development. The interactions between TFIIA and transcription factors activated by Ras in vivo can thus be genetically dissected and appear to support previous in vitro studies.FI25 was isolated and sequenced and encodes a novel protein. It is expressed during embryonic and eye development. A P-element allele of FI25 was obtained and represents a hypomorphic mutation in the locus which is characterised by a failure of rhabdomere development. Additional alleles of FI25 were generated by remobilisation of the mutagenic P-element insertion and are currently being investigated.
Download or read book Epidermal Growth Factor Receptor Signalling Regulates Ommatidial Rotation During Drosophila Eye Development written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell motility is essential for many aspects of normal animal development. However, little is known about how cell motility and associated changes in cell shape are regulated in the context of epithelial tissue patterning. This study investigates the cell motility of developing ommatidia, a process known as ommatidial rotation, during Drosophila eye development. The Drosophila eye consists of approximately 800 ommatidia that have to be precisely aligned with respect to one another for proper eye function. This precise alignment is achieved as ommatidia rotate 90° within the plain of the eye imaginal disc epithelium. Only a few mutations have been identified that disrupt this process and the signalling pathways regulating ommatidial rotation remain yet to be revealed. This study characterizes the argosroulette mutation, in which ommatidia rotate to various degrees. Argos is a secreted inhibitor of Spitz, the main activating ligand of the Epidermal growth factor receptor (Egfr). The experiments presented show that modulation of Egfr activity causes defects in ommatidial rotation and implicate the Raf/MAPK/Pointed cascade as well as the Ras binding protein Canoe as downstream effectors of Egfr/Ras in this process. Furthermore, evidence is provided indicating that the regulation of cell adhesion via cadherins is critical for this process. In particular, the atypical cadherin flamingo, a gene known to regulate epithelial planar polarity, appears to play a key role in ommatidial rotation, as its sub-cellular localisation is disturbed in argosroulette mutants. Genetic interactions further implicate non-muscle Myosin II as well as genes involved in actin polymerisation/depolymerisation in this process. This study also describes the design of an F1 screen intended to identify new genes involved in ommatidial rotation. Preliminary results obtained in a pilot screen identified the Drosophila PDGF/VEGF receptor orthologue (PVR) as a candidate. The requirement of Egfr and a poten.
Download or read book The Establishment of Planar Polarity in the Drosophila Compound Eye written by Manolis Fanto and published by . This book was released on 1999 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Biology of Cadherins written by and published by Academic Press. This book was released on 2013-03-08 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book Behavioral Genetics of the Fly Drosophila Melanogaster written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Download or read book Animal Anomalies written by Lewis I. Held, Jr and published by Cambridge University Press. This book was released on 2021-03-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights what we know about the pathways pursued by embryos and evolution, and stresses what we do not yet know.
Download or read book Planar Cell Polarity During Development written by and published by Academic Press. This book was released on 2012-12-31 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Current Topics in Developmental Biology covers the area of Planar Cell Polarity with contributions from an international board of authors. The 12 chapters provide a comprehensive set of reviews covering such topics as PCP in Zebra fish, the role of Dishevelled in PCP regulation, and PCP in axon pathfinding. Covers the area of planar cell polarity International board of authors 12 chapters provide a comprehensive set of reviews covering such topics as planar cell polarity in Zebrafish, the role of disheveled in planar cell polarity regulation, and planar cell polarity in axon path finding
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in the Drosophila Eye written by Amit Singh and published by Springer Science & Business Media. This book was released on 2013-09-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.
Download or read book Cell Polarity and Morphogenesis written by and published by Academic Press. This book was released on 2017-02-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity and Morphogenesis, the latest volume in the Methods in Cell Biology series, looks at cell polarity and morphogenesis. Edited by leaders in the field, this volume provides proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physical Biology of the Cell written by Rob Phillips and published by Garland Science. This book was released on 2012-10-29 with total page 1089 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that
Download or read book Journal of Cell Science written by and published by . This book was released on 2004 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Oxford Handbook of Invertebrate Neurobiology written by John H. Byrne and published by Oxford University Press. This book was released on 2019-01-29 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.
Download or read book Pediatric Retina written by James D. Reynolds and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric retinal diseases are not simply retinal diseases that occur in children; rather, they are unique disorders that often are not found in adults. This textbook of the pediatric retina offers in-depth guidance on congenital and acquired diseases of the retina in the pediatric population. It is organized according to disease onset and timing, as well as anatomy. All chapters are written by leading authorities in the field from both the pediatric and the retinal perspective. A multidisciplinary approach to the topic is adopted, and critical information is included on disease classification and diagnosis, pathophysiology, genetics, complications, and prognosis. Pediatric Retina will be a useful source of information for pediatric ophthalmologists, retina specialists, and other eye care providers who care for children.
