Download or read book A Functional Analysis of the Kaposi s Sarcoma associated Herpesvirus G Protein coupled Receptor written by and published by . This book was released on 2007 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure function Analysis of the Constitutive Activity of Kaposi s Sarcoma associated Herpesvirus G Protein coupled Receptor KSHV GPCR written by Hao H. Ho and published by . This book was released on 2002 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kaposi Sarcoma Herpesvirus New Perspectives written by Chris Boshoff and published by Springer Science & Business Media. This book was released on 2006-10-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: will follow
Download or read book Functional Analysis of Kaposi s Sarcoma associated Herpesvirus ORF57 RNA Binding Motifs written by Adam Taylor and published by . This book was released on 2011 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kaposi Sarcoma New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Kaposi Sarcoma in a concise format. The editors have built Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Kaposi Sarcoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Kaposi Sarcoma: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Structural and Functional Analysis of the Kaposi s Sarcoma associated Herpesvirus VFLIP Internal Ribosome Entry Site written by Mariam K. Sulaiman and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Analysis of the Latent Origin for DNA Replication of Kaposi s Sarcoma associated Herpesvirus written by Jianhong Hu and published by . This book was released on 2005 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Kaposi s Sarcoma associated Herpesvirus G protein Coupled Receptor KSHV GPCR Biology written by Anjali Varma and published by . This book was released on 2000 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Analysis of the Latency associated Nuclear Antigen of Kaposi s Sarcoma associated Herpes Virus written by Alexander Charles Garber and published by . This book was released on 2002 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Elucidation of a Proteolytic Mechanism Required for Kaposi s Sarcoma associated Herpesvirus Replication written by Alan Brown Marnett and published by . This book was released on 2005 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpesviruses represent one of the most prevalent human pathogens worldwide. Infection results in a number of diseases ranging from cold sores to cancer. Yet despite the large clinical variation in disease states, the proteins expressed during the lytic cycle of all herpesviruses are highly conserved. A maturational serine protease is expressed late in viral replication and is required for production of properly assembled infectious progeny. In vitro structural and functional analysis has revealed the enzyme possesses a novel protein fold and is activated by dimerization. However, the mechanism of regulation of the enzyme both at a molecular level and in the context of viral replication is unknown. Positional scanning synthetic combinatorial libraries were used to define the substrate specificity of the protease encoded by Kaposi's Sarcoma-associated herpesvirus (KSHV). The strict specificity observed was used to guide the design and synthesis of a peptidyl-diphenylphosphonate inhibitor targeting the active site of the enzyme. Covalent modification of the active site serine of the enzyme by the transition-state analog inhibitor dramatically shifted the equilibrium toward dimeric enzyme illustrating the intimate communication between the spatially separate active sites and dimer interface of the protease. To elucidate the mechanism of stabilization and activation during catalysis, structural analysis was performed on purely monomeric (M197D), purely dimeric (inhibited) and an equilibrium mixture (uninhibited wild-type) by circular dichroism and nuclear magnetic resonance. A massive conformational change was observed upon loss of dimerization in which helices 5 and 6, at the interface and active site, respectively, become disordered, which destabilizes essential catalytic components. A disulfide bond was engineered into the protease at helix 6 that prevented the conformational change and subsequent inactivation of the enzyme. Addition of oxidant or reductant reversibly recovered or abolished enzymatic activity, respectively, even in a monomeric variant of the protease. A reduction in viral replication similar to currently available therapies targeting the viral polymerase was observed upon treatment of reactivated KSHV with the protease inhibitor. The work not only validated the virally-encoded protease as a potential therapeutic target, but also presented a mechanism by which protease inhibition may occur in vivo .
Download or read book Characterization of a G Protein coupled Receptor Encoded by the Rhesus Macaque Viral Homologue of Human Herpesvirus 8 HHV 8 Kaposi s Sarcoma associated Herpesvirus KSHV written by Ryan D. Estep and published by . This book was released on 2004 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book A Genome wide Analysis of Protein protein Interactions in Kaposi s Sarcoma associated Herpesvirus KSHV written by Christine Zeretzke and published by . This book was released on 2006 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV AIDS Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.
Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.
Download or read book Human Retrovirus Protocols written by Tuofu Zhu and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of basic and state-of-the-art methods optimized for investigating the molecular biology of this class of retrovirus. These readily reproducible techniques range from methods for the isolation and detection of human retroviruses to cutting-edge methods for exploring the interplay between the viruses and the host. Here, the researcher will find up-to-date techniques for the isolation and propagation of HIV, HTLV, and foamy virus from a variety of sources. There are also assays for determining the cell tropism of HIV-1, the coreceptor usage of HIV-1, and human gene expression with HIV-1 infection by microarrays, as well as for phenotyping HIV-1 infected monocytes and examining their fitness. Highlights include the detection and quantification of HIV-1 in resting CD4+, a new cloning system for making recombinent virus, cDNA microarrays, and the determination of genetic polymorphisms in two recently identified HIV-1 co-factors that are critical for HIV-1 infection.
Download or read book Human Herpesviruses written by Yasushi Kawaguchi and published by Springer. This book was released on 2018-06-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.
