Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Download or read book Intense Neutron Sources written by U.S. Atomic Energy Commission and published by . This book was released on 1966 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment written by Narayan S Hosmane and published by World Scientific. This book was released on 2012-03-07 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer. This book was released on 2013-05-17 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
Download or read book Neutron Generators for Analytical Purposes written by International Atomic Energy Agency and published by IAEA Radiation Technology Repo. This book was released on 2012 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication addresses recent developments in neutron generator (NG) technology. It presents information on compact instruments with high neutron yield to be used for neutron activation analysis (NAA) and prompt gamma neutron activation analysis in combination with high count rate spectrometers. Traditional NGs have been shown to be effective for applications including borehole logging, homeland security, nuclear medicine and the on-line analysis of aluminium, coal and cement. Pulsed fast thermal neutron analysis, as well as tagged and timed neutron analysis, are additional techniques which can be applied using NG. Furthermore, NG can effectively be used for elemental analysis and is also effective for analysis of hidden materials by neutron radiography. Useful guidelines for developing NG based research laboratories are also provided in this publication.
Download or read book Photoneutron Sources written by B. W. Sargent and published by . This book was released on 1946 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetry written by Lennart Lindborg and published by CRC Press. This book was released on 2020-10-02 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master's and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.
Download or read book Boron Based Compounds written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2018-07-23 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Download or read book Thermal Neutron Scattering written by Peter A. Egelstaff and published by . This book was released on 1965 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Spallation Research written by Detlef Filges and published by Wiley-VCH. This book was released on 2010-02-01 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed and comprehensive reference to spallation -- from the foundations to the latest applications is the only work of its kind and is written by two internationally renowned researchers. Clearly divided into three parts, it begins with the basic principles, while the second part describes the proton-nucleus and proton-matter experiments so-called thin and thick target experiments in terms of secondary particle production as hadrons, pions, muons, photons, electrons, light and intermediate masses, isotope production, heating and energy deposition and materials damage. Many of the experiments are associated with studies, investigations and the construction of spallation neutron sources since 1975 with emphasis on the most recent developments. The final part on technology and applications describes the various engineering problems associated with high intensity neutron spallation sources, ATW's, the needed accelerator systems, material and neutron issues, and high energy neutron source shielding aspects. A must-have for engineers and physicists working in or entering this field.
Download or read book Neutron Beam Design Development and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Download or read book Advances in Neutron Capture Therapy written by A.H. Soloway and published by Springer Science & Business Media. This book was released on 1993 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Download or read book Particle Detectors written by Hermann Kolanoski and published by Oxford University Press. This book was released on 2020-06-30 with total page 949 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamentals of particle detectors as well as their applications. Detector development is an important part of nuclear, particle and astroparticle physics, and through its applications in radiation imaging, it paves the way for advancements in the biomedical and materials sciences. Knowledge in detector physics is one of the required skills of an experimental physicist in these fields. The breadth of knowledge required for detector development comprises many areas of physics and technology, starting from interactions of particles with matter, gas- and solid-state physics, over charge transport and signal development, to elements of microelectronics. The book's aim is to describe the fundamentals of detectors and their different variants and implementations as clearly as possible and as deeply as needed for a thorough understanding. While this comprehensive opus contains all the materials taught in experimental particle physics lectures or modules addressing detector physics at the Master's level, it also goes well beyond these basic requirements. This is an essential text for students who want to deepen their knowledge in this field. It is also a highly useful guide for lecturers and scientists looking for a starting point for detector development work.
Download or read book Photon Electron Proton and Neutron Interaction Data for Body Tissues written by and published by International Commission on Radiation. This book was released on 1992-01-01 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.
