Download or read book A defect in the coactivation of HIF1 by PKM2 and PHD3 is implicated in a familial disorder which can cause autoinflammatory symptoms connective tissue symptoms and psychosis written by John Neville and published by Lulu.com. This book was released on 2019-08-26 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: A defect in the coactivation of HIF1 by PKM2 and PHD3 (interaction 1) is implicated in a familial disorder which can cause autoinflammatory symptoms, connective tissue symptoms and psychosis. It is suggested that interaction 1 may act in concert with the binding of a STAT1/PPARG complex to the CD36 promotor (interaction 2) to regulate the flux of pyrroline-5-carboxylic acid, whether to proline synthesis or to the urea cycle. It is proposed that these two interactions may provide for viable treatment targets in schizophrenia where hyperprolinemia is present.
Download or read book EGLN1 EGLN2 EGLN3 inhibitors as possible treatments for psychotic disorders schizopnrenia associated with Parkinson s disease written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A hypothesis that proposes that defects in PHD2 and PHD3 function may be causal of the symptoms of schizopnrenia written by John Neville and published by Lulu.com. This book was released on 2019-09-08 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: A defect in the coactivation of HIF1 by PKM2 and PHD3 has been implicated in a familial disorder which can cause autoinflammatory symptoms, connective tissue symptoms and psychosis. It has also been pointed out that a majority of predicted target genes of HIF1 are associated with schizopnrenia, or have altered function or expression in schizopnrenia. PHD2 and PHD3 both regulate HIF1a. Here it is noted that PHD2 (EGLN1) is located at 1q42.2, very close to the location of DISC1 and DISC2, whilst PHD3 (EGLN3) is located at 14q13.1, very close to the location of NPAS3. The disruption of DISC1 and DISC2 genes by a translocation co-segregating with familial schizopnrenia is well known. A mutation in NPAS3 also segregates with schizophrenia in a small family. This raises the interesting possibility that defective PHD2 and PHD3 function could be causal of the symptoms of schizopnrenia.
Download or read book EGLN3 keratin and Morganelles Disorder and their possible roles in the pathogenesis of Borderline Personality Disorder Bipolar Disorder schizopnrenia and anxiety written by John Neville and published by Lulu.com. This book was released on with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
