Download or read book A Critical Review of Sickle Cell written by National Association for Sickle Cell Disease (U.S.). Scientific Advisory Committee and published by . This book was released on 1973 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.
Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Download or read book Sickle Cell Anemia written by Jane S. Lin-Fu and published by . This book was released on 1972 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sickle Cell Disease written by Graham R. Serjeant and published by Oxford University Press, USA. This book was released on 1985 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most common inherited blood disorders, sickle cell disease affects large numbers of people throughout the world. This comprehensive volume provides an up-to-date review of the clinical management of sickle cell disease. Distilling the large amount of information scattered throughout the medical literature, Serjeant summarizes advances in three areas of clinical importance--diagnosis, clinical features, and therapy. He also offers a critical review of the extensive literature on the subject, and includes a comprehensive list of references.
Download or read book Understanding Sickle Cell Disease written by Miriam Bloom and published by Univ. Press of Mississippi. This book was released on 2009-10-20 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although more is known about sickle cell disease than about any other inherited disease, no cure for it exists. In America alone, about one in 375 who are of African ancestry is born with sickle cell disease. A smaller number of Americans descended from families from the Mediterranean area, the Middle East, and India also are affected. In addition, about eight percent of black Americans who do not suffer from the disease itself carry the gene for it that can be transmitted to their children. Sickle cell disease is of enormous biological, social, and historic importance. It was first described in medical literature almost a century ago. Improvements during the past two decades in our understanding of the disease and in medical care are permitting those afflicted to live longer, more comfortable and more productive lives. This book was written for all who are interested in this disease--those who have it, their families, the carriers of the sickle cell gene, teachers, and those who wish to update their information about it. This overview of sickle cell disease explains what it is and how it is inherited, as well as the relationship between the sickle cell gene and its geographic origins, the way the gene has been spread throughout history, and the effect of sickle cell hemoglobin on red blood cells that carry it. Understanding Sickle Cell Disease describes the variety of symptoms in both children and adults and details the emotional aspects of the disease. Of particular interest is a chapter on the care, especially the home care, of those who are affected. This book explains how it is possible today for couples carrying the genes to raise families free of the disease. Although there is no known cure for sickle cell disease, there is little doubt that one will ultimately be devised. This volume surveys current research efforts and the promise they hold.
Download or read book The Management of Sickle Cell Disease written by U. S. Department of Health and published by Createspace Independent Publishing Platform. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 Best Seller on Sickle Cell Disease (SCD). Sickle cell disease is a group of blood disorders passed down from parents to children. Sickle cell anemia shortens life expectancy by 30 years via bacterial infections, painful swellings, fever, arthritis, leg ulcers, eye, lung & heart damage. Over 100,000 people, mostly African-Americans, in the United States have sickle cell disease. Over 2 million people have sickle cell trait in America. It is estimated that more than 300,000 children are born each year with SCD around the world. This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: 1. Diagnosis and Counseling 2. Health Maintenance 3. Treatment of Acute and Chronic Complications 4. Special Topics. The original intent was to incorporate evidence-based medicine into each chapter, but there was variation among evidence-level scales, and some authors felt recommendations could be made, based on accepted practice, without formal trials in this rare disorder. The best evidence still is represented by randomized, controlled trials (RCTs), but variations exist in their design, conduct, endpoints, and analyses. It should be emphasized that selected people enter a trial, and results should apply in practice specifically to populations with the same characteristics as those in the trial. Randomization is used to reduce imbalances between groups, but unexpected factors sometimes may confound analysis or interpretation. In addition, a trial may last only a short period of time, but long-term clinical implications may exist. Another issue is treatment variation, for example, a new pneumococcal vaccine developed after the trial, which has not been tested formally in a sickle cell population. Earlier trial results may be accepted, based on the assumption that the change is small. In some cases, RCTs cannot be done satisfactorily (e.g., for ethical reasons, an insufficient number of patients, or a lack of objective measures for sickle cell "crises"). Thus the bulk of clinical experience in SCD still remains in the moderately strong and weaker categories of evidence. Not everyone has an efficacious outcome in a clinical trial, and the frequency of adverse events, such as with long-term transfusion programs or hematopoietic transplants, might not be considered. Thus, an assessment of benefit-to-risk ratio should enter into translation of evidence levels into practice recommendations. A final issue is that there may be two alternative approaches that are competitive (e.g., transfusions and hydroxyurea). In this case the pros and cons of each course of treatment should be discussed with the patient. This book is B&W copy of the government agency publication.
Download or read book Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies written by Stephan Lobitz and published by MDPI. This book was released on 2019-10-07 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
Download or read book Evidence Based Management of Sickle Cell Disease written by M D George R Buchanan and published by Createspace Independent Publishing Platform. This book was released on 2014-09-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease can be severe and disabling. When properly treated, patients live longer and with better quality life. This is a US government publication intended to provide evidence-based guidelines for the care of these patients for the use of all concerned providers as well as patients and family members. This book is available in print here for convenience.
Download or read book Sickle cell anemia written by Jane S. Lin-Fu and published by . This book was released on 1972 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Download or read book Principles of Critical Care 4th edition written by John Kress and published by McGraw-Hill Education / Medical. This book was released on 2015-06-02 with total page 1792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quickly and accurately diagnose and treat the critically ill patient with guidance from the field's definitive text "...Clearly the finest textbook available in the field." -- Critical Care Medicine journal "...Very well done...unusually user-friendly...excellent...a significant contribution to the field. It should be placed not only in the critical care practitioner's library, but also in the rounds and nurses' conference rooms of critical care units." -- Journal of the American Medical Association Considered the field's definitive text, Principles of Critical Care offers unmatched coverage of the diagnosis and treatment of the most common problems encountered in the practice of critical care. Written by expert critical care physicians who are also experienced teachers, the book features an organization, thoroughness, and clarity not found in any other reference on the topic. Within its pages, you will find comprehensive, authoritative discussion of every aspect of critical care medicine essential to successful clinical practice, ranging from basic principles to the latest technologies. The fourth edition is highlighted by: A new full-color presentation NEW CHAPTERS on ICU Ultrasound, Extracorporeal Membrane Oxygenation, ICU-Acquired Weakness, Abdominal Compartment Syndrome, and Judging the Adequacy of Intravascular Volume The addition of many new figures and diagnostic and treatment algorithms In-depth, up-to-date descriptions of the unique presentation, differential diagnosis, and management of specific critical illnesses A logical organ system approach that simplifies the search for thorough and practical information necessary to manage a patient’s specific condition The integration of pathophysiology throughout the text Content that reflects today’s interdisciplinary approach to critical care medicine *Reviews are of previous editions
Download or read book Pathophysiology of Blood Disorders written by Howard Franklin Bunn and published by McGraw Hill Professional. This book was released on 2010-12-27 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise full-color review of the mechanisms of blood diseases and disorders – based on a Harvard Medical School hematology course 4 STAR DOODY'S REVIEW! "This is a superb book. Deceptively small, yet packs a wallop. The emphasis on principles instead of practice is welcome....The text is clear, concise, and surprisingly approachable for what could have been a very dense and dry discussion. I could not put this book down and read it entirely in one sitting. When was the last time anyone found a hematology textbook so riveting?"--Doody's Review Service Hematological Pathophysiology is a well-illustrated, easy-to-absorb introduction to the physiological principles underlying the regulation and function of blood cells and hemostasis, as well as the pathophysiologic mechanisms responsible for the development of blood disorders. Featuring a strong emphasis on key principles, the book covers diagnosis and management primarily within a framework of pathogenesis. Authored by world-renowned clinician/educators at Harvard Medical School, Hematological Pathophysiology features content and organization based on a hematology course offered to second year students at that school. The book is logically divided into four sections: Anemias and Disorders of the Red Blood Cell, Disorders of Hemostasis and Thrombosis, Disorders of Leukocytes, and Transfusion Medicine; it opens with an important overview of blood and hematopoietic tissues. Features Succinct, to-the-point coverage that reflects current medical education More than 200 full-color photographs and renderings of disease mechanisms and blood diseases Each chapter includes learning objectives and self-assessment questions Numerous tables and diagrams encapsulate important information Incorporates the feedback of 180 Harvard medical students who reviewed the first draft -- so you know you’re studying the most relevant material possible
Download or read book The Enculturated Gene written by Duana Fullwiley and published by Princeton University Press. This book was released on 2011-11-07 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell "mild" in a social setting where public health priorities and economic austerity programs have forced people to improvise informal strategies of care. Duana Fullwiley shows how geneticists, who were fixated on population differences, never investigated the various modalities of self-care that people developed in this context of biomedical scarcity, and how local doctors, confronted with dire cuts in Senegal's health sector, wittingly accepted the genetic prognosis of better-than-expected health outcomes. Unlike most genetic determinisms that highlight the absoluteness of disease, DNA haplotypes for sickle cell in Senegal did the opposite. As Fullwiley demonstrates, they allowed the condition to remain officially invisible, never to materialize as a health priority. At the same time, scientists' attribution of a less severe form of Senegalese sickle cell to isolated DNA sequences closed off other explanations of this population's measured biological success. The Enculturated Gene reveals how the notion of an advantageous form of sickle cell in this part of West Africa has defined--and obscured--the nature of this illness in Senegal today. Some images inside the book are unavailable due to digital copyright restrictions.
Download or read book Drawing Blood written by Keith Wailoo and published by JHU Press. This book was released on 2002-10-15 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: How physicians in this century wielded medical technology to define disease, carve out medical specialties, and shape political agendas. Winner of the American Public Health Association Arthur Viseltear Prize In Drawing Blood, medical historian Keith Wailoo uses the story of blood diseases to explain how physicians in this century wielded medical technology to define disease, carve out medical specialties, and shape political agendas. As Wailoo's account makes clear, the seemingly straightforward process of identifying disease is invariably influenced by personal, professional, and social factors—and as a result produces not only clarity and precision but also bias and outright error. Drawing Blood reveals the ways in which physicians and patients as well as the diseases themselves are simultaneously shaping and being shaped by technology, medical professionalization, and society at large. This thought-provoking cultural history of disease, medicine, and technology offers an important perspective for current discussions of HIV and AIDS, genetic blood testing, prostate-specific antigen, and other important issues in an age of technological medicine. "Makes clear that the high stakes involved in medical technology are not just financial, but moral and far reaching. They have been harnessed to describe clinical phenomena and to reflect social and cultural realities that influence not only medical treatment but self-identity, power, and authority."—Susan E. Lederer, H-Net Humanities & Social Sciences On Line "Wailoo's masterful study of hematology and its disease discourse is a model of interdisciplinarity, combining cultural analysis, social history, and the history of medical ideas and technology to produce a complex narrative of disease definition, diagnosis, and treatment . . . He reminds us that medical technology is a neutral artifact of history. It can be, and has been, used to clarify and to cloud the understanding of disease, and it has the potential both to constrain and to emancipate its subjects."—Regina Morantz-Sanchez, Journal of Interdisciplinary History
Download or read book Sickle Cell Anemia written by Fernando Ferreira Costa and published by Springer. This book was released on 2016-03-29 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
Download or read book In the Blood written by Melbourne Tapper and published by University of Pennsylvania Press. This book was released on 1999-02-04 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although it strikes individuals from a variety of backgrounds, sickle cell anemia has always been known as a "black" disease in America. In the Blood argues that ever since the discovery in 1910 and subsequent scientific analysis of the disease, sickle cell anemia has been manipulated to serve social ends-as a tool for securing white identity and a way to establish a hierarchy based on European heritage. Tapper shows how sickle cell anemia was used to promote the superiority of racial purity, to characterize the black body as contaminated, and even to support the notion that modern humans evolved from multiple origins.
