Download or read book A Computational and Experimental Study of a Heart model based Electrocardiographic Imaging Approach written by Xin Zhang (Ph.D.) and published by . This book was released on 2005 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Introduction to Computational Cardiology written by Boris Ja. Kogan and published by Springer Science & Business Media. This book was released on 2009-12-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Computational Cardiology provides a comprehensive, in-depth treatment of the fundamental concepts and research challenges involved in the mathematical modeling and computer simulation of dynamical processes in the heart, under normal and pathological conditions. About this textbook: - Presents descriptions of models used in both biology and medicine for discovering the mechanisms of heart function and dysfunction on several physiological scales across different species. - Provides several examples throughout the textbook and exercises at the end which facilitate understanding of basic concepts and introduces, for implementation, treated problems to parallel supercomputers. Introduction to Computational Cardiology serves as a secondary textbook or reference book for advanced-level students in computer science, electrical engineering, biomedical engineering, and cardiac electrophysiology. It is also suitable for researchers employing mathematical modeling and computer simulations of biomedical problems.
Download or read book Electrocardiographic Imaging written by Maria S. Guillem and published by Frontiers Media SA. This book was released on 2020-04-17 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation
Download or read book ModelBased Approaches to Incorporate Recordings of Multiple Heartbeats Into the Inverse Problem of Electrocardiography written by Jaume Coll-Font and published by . This book was released on 2016 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solutions to the inverse problem of electrocardiography, also known as Electrocardiographic Imaging (ECGI), non-invasively image the electrical activity of the heart to localize and quantify normal and abnormal cardiac electrophysiology, and have recently attracted considerable attention in the research community. These methods have great promise to aid planning of catheter ablation procedures as well as for screening and diagnosis. They solve a problem that uses electrocardiographic measurements on the body surface (ECGs) to characterize the unknown electrical activity of the heart, here described by the time series of distribution of electrical potential on the heart surface. To do so, they rely on the calculation of a "forward" model relating the potentials on the heart with the ECGs, typically known as "forward matrix". However, ECGI has some limitations that impede its application to routine clinical practice. One of them is the ill-posedness of the forward model, which causes inverse solutions to be unreliable even with small levels of noise in the inputs and the model. One way of improving the resilience to this problem is to increase the Signal to Noise Ratio (SNR) of the signal by the incorporation of recordings from multiple heartbeats. During the course of this thesis we have addressed this approach in several applications: imaging the presence of T-wave alternans on the heart, localizing the site of earliest activation of pre-ventricular contractions (PVC) and the characterization of the errors introduced in the forward matrix. T-wave alternans (TWA), defined as a beat-to-beat alternation of the T-wave in the ECG, have been advocated for the past two decades as a promising marker of susceptibility to sudden cardiac death (SCD). However current ECG tests for TWA have been reported to have high sensitivity but low specificity for SCD and thus there is still no consensus on their predictive value. The distinction between concordant alternans---for which the whole heart alternates at the same phase---and discordant alternans---for which different regions of the heart alternate in different magnitude and phase---is of special interest as the latter have been observed preceding ventricular fibrillation in animal experiments and simulations. Thus, better characterization of the spatial behavior of discordant alternans could lead to improvements in the predictive value of TWA tests. Motivated by the desire to identify and localize discordant regions from body surface measurements, we present two studies related to TWA. In the first we introduce a theoretical characterization of how concordant and discordant alternans appear on the body surface. In the second study we present a method that directly estimates the location and phase of discordant TWA on the heart surface from body surface measurements by combining techniques from TWA detection with the methodology of ECGI. The results obtained with both studies on TWA suggest considerable promise that these methods may help increase our ability to understanding TWA based on body surface recordings, and thereby more clearly study its link to SCD, by providing previously unavailable spatial information to researchers and clinicians. Accurate detection of the site of first activation in a pre-ventricular contraction (PVC) can lead to substantial improvements in pre-procedure planning for ablation interventions and the subsequent reduction length and costs of these interventions. However, to be able to accurately localize these sites, it is necessary to obtain reliable inverse reconstructions of the activation wavefront that propagates throughout the heart during QRS. In this thesis, we present two approaches to increase the SNR through the incorporation of multiple recordings from the same underlying PVC activity. In the first one, we study deterministic averaging approaches to incorporate multiple heartbeats in an inverse solver. In the second one, we extend the previous averaging approaches into a statistically inspired model to characterize the beat-to-beat fluctuations observed on the ECG. These studies showed some improvement over regular averaging techniques, but the beat-to-beat variability still present in the solutions suggested that there is need to better characterize the sources of noise, which led to the third contribution of this thesis. Model mismatch in the forward matrix is a significant factor in inverse solution error. This is particularly problematic when incorporating multiple heartbeat recordings, as the heart moves within the thorax from beat to beat due to respiration. Therefore, the use of a single forward matrix necessarily introduces model errors in this setting. To overcome this limitation, we propose in this work to efficiently characterize the changes in the forward matrix due to movements of the heart and then adapt the forward matrix to each individual heartbeat. With that objective we developed a new method to characterize errors in the forward matrix that are produced by movement of the heart. This method approximates the changes in volume conductor geometry with a parameterized transform and then encapsulates the forward matrices that these changes would generate into a single mapping function that describes the whole sequence of computations. With this mapping, it is then possible to apply optimization methods that correct for the errors in the forward matrix, generating an approximate forward matrix corresponding to an estimated position and orientation of the heart and, if desired, also solve for the unknown cardiac electrical potentials in an iterative fashion. We expect this work to impact ECGI research and beyond. In ECGI, we expect to improve results in animal models used for understanding mechanisms and validating inverse solutions and to reduce uncertainty of inverse solutions obtained in clinical applications, and to expand the range of potential clinical problems for which ECGI can be reasonably applied by reducing the need for extensive high resolution anatomical imaging. Beyond ECGI, the capacity to non-invasively track the position of the heart has the potential to impact a number of other clinical problems, for example, improving catheter registration in ablation procedures.
Download or read book Computational Modeling and Simulation Examples in Bioengineering written by Nenad Filipovic and published by John Wiley & Sons. This book was released on 2021-12-14 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A systematic overview of the quickly developing field of bioengineering—with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.
Download or read book Comprehensive Electrocardiology written by Peter W. Macfarlane and published by Springer Science & Business Media. This book was released on 2010-11-05 with total page 2310 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition of the classic complete reference book for cardiologists and trainee cardiologists on the theory and practice of electrocardiography, one of the key modalities used for evaluating cardiology patients and deciding on appropriate management strategies.
Download or read book Cardiac Electrophysiology Methods and Models written by Daniel C. Sigg and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.
Download or read book Cardiac Mapping written by Mohammad Shenasa and published by John Wiley & Sons. This book was released on 2012-10-17 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Mapping is the cardiac electrophysiologist’s GPS. It will guide you to new places in the heart and help you find the old places more easily...a valuable addition to your bookshelf Douglas P. Zipes, from the Foreword. Over the course of three previous editions, this book has become the acknowledged gold standard reference on the electro-anatomical mapping of the heart. This new edition features greatly expanded coverage—the number of chapters have doubled to 80 with 40 new chapters—on leading edge science, new clinical applications and future frontiers, authored by a who’s-who of global electrophysiology. This unique text offers truly comprehensive coverage of all areas of cardiac mapping, from core scientific principals to methodological and technical considerations to the latest data that you can put to work caring for patients. In addition, the all new 4th edition adds essential content on: Mapping in experimental models of arrhythmias Mapping supraventricular and ventricular tachyarrhythmias New catheter-based techniques Also featuring a companion website with video clips illustrating essential techniques described in the text The only state-of-the-art, stand-alone text on this dynamic subject, Cardiac Mapping is an essential resource for basic scientists, clinical electrophysiologists, cardiologists and all physicians who care for patients with cardiac arrhythmias.
Download or read book Computational Methods in Cardiac Electrophysiology written by Matthijs Cluitmans and published by Frontiers Media SA. This book was released on 2023-07-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modeling Imaging of Bioelectrical Activity written by Bin He and published by Springer Science & Business Media. This book was released on 2010-07-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past several decades, much progress has been made in understanding the mechanisms of electrical activity in biological tissues and systems, and for developing non-invasive functional imaging technologies to aid clinical diagnosis of dysfunction in the human body. The book will provide full basic coverage of the fundamentals of modeling of electrical activity in various human organs, such as heart and brain. It will include details of bioelectromagnetic measurements and source imaging technologies, as well as biomedical applications. The book will review the latest trends in the field and comment on the future direction in this fast developing line of research.
Download or read book Imaging for Patient Customized Simulations and Systems for Point of Care Ultrasound written by M. Jorge Cardoso and published by Springer. This book was released on 2017-09-06 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed joint proceedings of the International Workshop on Bio-Imaging and Visualization for Patient-Customized Simulations, BIVPCS 2017, and the International Workshop on Point-of-Care Ultrasound, POCUS 2017, held in conjunction with the 20th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2017, in Québec City, QC, Canada, in September 2017. The 12 full papers presented at BIVPCS 2017 and the 7 full papers presented at POCUS 2017 were carefully reviewed and selected. The papers feature research from complementary fields such as signal and image processing, mechanics, computational vision, mathematics, physics, informatics, computer graphics, bio-medical-practice, psychology and industry as well as ultrasound image systems applications.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Artificial Intelligence in Heart Modelling written by Rafael Sebastian and published by Frontiers Media SA. This book was released on 2022-05-11 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Statistical Atlases and Computational Models of the Heart written by Oscar Camara and published by Springer Science & Business Media. This book was released on 2010-09-03 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: computationalmodelswith experimentaldata. A completedatasetwasprovided in advance, containing the cardiac geometry and ?bre orientations from MRI as well as epicardial transmembrane potentials from optical mapping.
Download or read book Image based Computational Approaches for Personalized Cardiovascular Medicine Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data written by Selene Pirola and published by Frontiers Media SA. This book was released on 2023-07-13 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book J Wave Syndromes written by Charles Antzelevitch and published by Springer. This book was released on 2016-06-27 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.
Download or read book Cardiac Modeling Aiming for Optimization of Therapy written by Javier Saiz and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
